Confined DART-MS for Rapid Chemical Analysis of Electronic Cigarette Aerosols and Spiked Drugs

Forbes, Thomas P.; Krauss, Shannon T.

doi:10.1021/jasms.1c00103

Cited by 8 publications

(10 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Direct online analysis of single puff MSS is important for identifying the chemicals entering the smoker’s lungs and is beneficial for further understanding the health effect of smoking . Forbes and Kraus presented a confined DART-MS method for direct analysis of electronic cigarette aerosols in <30 s …”

Section: Resultsmentioning

confidence: 99%

“…36 Direct online analysis of single puff MSS is important for identifying the chemicals entering the smoker's lungs and is beneficial for further understanding the health effect of smoking. 37 Forbes and Kraus presented a confined DART-MS method for direct analysis of electronic cigarette aerosols in <30 s. 38 To further demonstrate the capability of the Tee-shaped device for the analysis of a complex gas sample, Figure 4 shows the puff-by-puff analysis of gaseous MSS of a standard cigarette. The results include a total ion chronogram (TIC) for seven consecutive puffs (Figure 4A) and corresponding mass spectra of individual puffs (Figure 4B).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Tee-Shaped Sample Introduction Device Coupled with Direct Analysis in Real-Time Mass Spectrometry for Gaseous Analytes

Geng

Zhao

et al. 2021

Anal. Chem.

View full text Add to dashboard Cite

Ambient ionization mass spectrometry (AIMS) is simple to operate for analytes adsorbed on the surface of various shaped probes. However, gaseous substances or liquids that are easy to evaporate, diffuse, and escape in the atmosphere are harder to capture. In this work, a Teeshaped sample introduction device coupled with direct analysis in real time mass spectrometry (DART-MS) is developed. The Tee-shaped device is placed between the DART ion source and the MS inlet with a heated sample transfer tube. Gaseous samples from either a Tedlar sampling bag or liquids evaporated from a graduated syringe were tested. The Tee-shaped device was used for several volatile organic compounds with a wide range of boiling points, and detection limits of ng/mL to fg/mL were obtained. To test the device for real-life samples, puff-by-puff analysis of a complex gaseous mainstream smoke was performed. Individual puffs can be analyzed rapidly, and there is no cross contamination between consecutive puffs. The dynamic changes of chemical components among different puffs for different types of cigarettes can be observed. This work provides a universal Tee-shaped sampling device to enhance AIMS for the analysis of volatile compounds and gases, which is adapted to different sampling modules applicable for various forms of samples. The device enables direct exploration of chemical components in complex gaseous samples without tedious sample preparation and time-consuming LC or GC separation.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Tee-Shaped Sample Introduction Device Coupled with Direct Analysis in Real-Time Mass Spectrometry for Gaseous Analytes

Geng

Zhao

et al. 2021

Anal. Chem.

View full text Add to dashboard Cite

show abstract

“…conducted a systematic study of paper substrate‐solvent combinations in the analysis of illicit drugs and chemical warfare agents to determine optimal conditions for different compound types 59 . Aside from paper spray, DART‐MS has also been readily utilized in the rapid analysis of drugs, including for the detection of synthetic cathinones in blood and urine, 60 the analysis of benzodiazepines in plasma, 61 the detection of cannabinoids in various complex matrices 62 and for the analysis of illicit drugs in electronic cigarette aerosols 63 …”

Section: Applications Of Ambient Ionization Mass Spectrometrymentioning

confidence: 99%

“…59 Aside from paper spray, DART-MS has also been readily utilized in the rapid analysis of drugs, including for the detection of synthetic cathinones in blood and urine, 60 the analysis of benzodiazepines in plasma, 61 the detection of cannabinoids in various complex matrices 62 and for the analysis of illicit drugs in electronic cigarette aerosols. 63 Recently, the applications of ambient ionization to drugs analysis have extended beyond the laboratory, with research focusing on the development of hand-held tools and methods that could be used in the field for the analysis of real-world samples to truly test the feasibility of such techniques. One recent study developed a hand-held laser diode thermal DESI MS method for the rapid analysis of solid illegal materials.…”

Section: Forensics and Securitymentioning

confidence: 99%

Applications of ambient ionization mass spectrometry in 2021: An annual review

Rankin‐Turner

Reynolds

Turner

et al. 2022

Analytical Science Advances

View full text Add to dashboard Cite

Ambient ionization mass spectrometry (AIMS) has revolutionized the field of analytical chemistry, enabling the rapid, direct analysis of samples in their native state. Since the inception of AIMS almost 20 years ago, the analytical community has driven the further development of this suite of techniques, motivated by the plentiful advantages offered in addition to traditional mass spectrometry. Workflows can be simplified through the elimination of sample preparation, analysis times can be significantly reduced and analysis remote from the traditional laboratory space has become a real possibility. As such, the interest in AIMS has rapidly spread through analytical communities worldwide, and AIMS techniques are increasingly being integrated with standard laboratory operations. This annual review covers applications of AIMS techniques throughout 2021, with a specific focus on AIMS applications in a number of key fields of research including disease diagnostics, forensics and security, food safety testing and environmental sciences. While some new techniques are introduced, the focus in AIMS research is increasingly shifting from the development of novel techniques toward efforts to improve existing AIMS techniques, particularly in terms of reproducibility, quantification and ease-of-use.

show abstract

“…The development of new analytical techniques that allow rapid aerosol screening leads to progress in online chemical characterization. Current online methods for the chemical characterization of aerosols include direct analysis in real-time (DART) MS, 12 Fourier-transform infrared spectroscopy (FTIR), 13 selected-ion flow-tube (SIFT) MS, 14 proton transfer reaction (PTR) MS, 15 and single-photon ionization (SPI) MS. 16 DART−MS, FTIR, SIFT−MS, PTR− MS, and SPI−MS can detect and semiquantify target compounds present in aerosols without sample handling. However, these techniques exhibit low resolution and selectivity in untargeted aerosol analyses.…”

Section: ■ Introductionmentioning

confidence: 99%

Application of Secondary Electrospray Ionization Coupled with High-Resolution Mass Spectrometry in Chemical Characterization of Thermally Generated Aerosols

Semren

Majeed

Fatarova

et al. 2022

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

Inhalation as a route for administering drugs and dietary supplements has garnered significant attention over the past decade. We performed real-time analyses of aerosols using secondary electrospray ionization (SESI) technology interfaced with high-resolution mass spectrometry (HRMS), primarily developed for exhaled breath analysis with the goal to detect the main aerosol constituents. Several commercially available inhalation devices containing caffeine, melatonin, cannabidiol, and vitamin B12 were tested. Chemical characterization of the aerosols produced by these devices enabled detection of the main constituents and screening for potential contaminants, byproducts, and impurities in the aerosol. In addition, a programmable syringe pump was connected to the SESI–HRMS system to monitor aerosolized active pharmaceutical ingredients (APIs) such as chloroquine, hydroxychloroquine, and azithromycin. This setup allowed us to detect caffeine, melatonin, hydroxychloroquine, chloroquine, and cannabidiol in the produced aerosols. Azithromycin and vitamin B12 in the aerosols could not be detected; however, our instrument setup enabled the detection of vitamin B12 breakdown products that were generated during the aerosolization process. Positive control was realized by liquid chromatography-HRMS analyses. The compounds detected in the aerosol were confirmed by exact mass measurements of the protonated and/or deprotonated species, as well as their respective collision-induced dissociation tandem mass spectra. These results reveal the potential wide application of this technology for the real-time monitoring of aerosolized active pharmaceutical ingredients that can be administered through the inhalation route.

show abstract

Confined DART-MS for Rapid Chemical Analysis of Electronic Cigarette Aerosols and Spiked Drugs

Cited by 8 publications

References 41 publications

Tee-Shaped Sample Introduction Device Coupled with Direct Analysis in Real-Time Mass Spectrometry for Gaseous Analytes

Tee-Shaped Sample Introduction Device Coupled with Direct Analysis in Real-Time Mass Spectrometry for Gaseous Analytes

Applications of ambient ionization mass spectrometry in 2021: An annual review

Application of Secondary Electrospray Ionization Coupled with High-Resolution Mass Spectrometry in Chemical Characterization of Thermally Generated Aerosols

Contact Info

Product

Resources

About