Confinement-Induced Self-Pumping in 3D Active Fluids

Varghese, Minu; Baskaran, Arvind; Hagan, Michael F.; Baskaran, Aparna

doi:10.1103/physrevlett.125.268003

Cited by 40 publications

(48 citation statements)

References 55 publications

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“…While boundary effects are typically short-ranged in an equilibrium system, confining an active system can redirect the hierarchical organization of its internal active stresses and thus qualitatively change its macroscopic emergent behavior. For example, confining active particles leads to system-spanning effects such as spontaneous flow 26 – 33 . Furthermore, deformable confining boundaries enable non-equilibrium boundary fluctuations 12 , 34 – 38 , including elongated tendrils and bolas 35 and budding 39 .…”

Section: Introductionmentioning

confidence: 99%

Vesicle shape transformations driven by confined active filaments

2021

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In active matter systems, deformable boundaries provide a mechanism to organize internal active stresses. To study a minimal model of such a system, we perform particle-based simulations of an elastic vesicle containing a collection of polar active filaments. The interplay between the active stress organization due to interparticle interactions and that due to the deformability of the confinement leads to a variety of filament spatiotemporal organizations that have not been observed in bulk systems or under rigid confinement, including highly-aligned rings and caps. In turn, these filament assemblies drive dramatic and tunable transformations of the vesicle shape and its dynamics. We present simple scaling models that reveal the mechanisms underlying these emergent behaviors and yield design principles for engineering active materials with targeted shape dynamics.

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Section: Introductionmentioning

confidence: 99%

Vesicle shape transformations driven by confined active filaments

2021

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“…The field of active matter has identified two key mechanisms that control self-organization of active stresses: (1) anisotropic interactions between active components that realign forces, and (2) confining boundaries. For example, interactions between self-propelled particles that drive interparticle alignment result in bands or flocks [9,10], changing the length and stiffness of active polymers leads to dramatic reorganization of active stresses [11,12], and confining active particles leads to system-spanning effects such as spontaneous flow [13][14][15][16][17][18][19][20]. Furthermore, deformable confining boundaries enable non-equilibrium boundary fluctuations [21][22][23][24][25][26], including elongated tendrils and bolas [22].…”

Section: Introductionmentioning

confidence: 99%

Vesicle shape transformations driven by confined active filaments

Peterson

Baskaran

Hagan

2021

Preprint

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In active matter systems, deformable boundaries provide a mechanism to organize internal active stresses and perform work on the external environment. To study a minimal model of such a system, we perform particle-based simulations of an elastic vesicle containing a collection of polar active filaments. The interplay between the active stress organization due to interparticle interactions and that due to the deformability of the confinement leads to a variety of filament spatiotemporal organizations that have not been observed in bulk systems or under rigid confinement, including highly-aligned rings and caps. In turn, these filament assemblies drive dramatic and tunable transformations of the vesicle shape and its dynamics. We present simple scaling models that reveal the mechanisms underlying these emergent behaviors and yield design principles for engineering active materials with targeted shape dynamics.

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“…An impactful class of active anisotropic fluids is based on reconstituted cytoskeletal elements, wherein the active stresses are generated by clusters of molecular motors that step along multiple filaments, driving their relative sliding (17,18). So far, the focus has been on quantifying the chaotic dynamics of cytoskeletal active matter in both the nematic and isotropic phases and methods of controlling their autonomous flows through boundaries and confinement (19)(20)(21)(22)(23)(24)(25)(26). However, being reconstituted from well-defined biochemical components, these systems provide a unique, yet so far largely unexplored, opportunity to elucidate the microscopic origins of the emergent chaotic dynamics, thus paving the way for developing predictive multiscale models (27)(28)(29).…”

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confidence: 99%

Active liquid crystals powered by force-sensing DNA-motor clusters

Tayar

Hagan

Dogic

2021

Proc. Natl. Acad. Sci. U.S.A.

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Cytoskeletal active nematics exhibit striking nonequilibrium dynamics that are powered by energy-consuming molecular motors. To gain insight into the structure and mechanics of these materials, we design programmable clusters in which kinesin motors are linked by a double-stranded DNA linker. The efficiency by which DNA-based clusters power active nematics depends on both the stepping dynamics of the kinesin motors and the chemical structure of the polymeric linker. Fluorescence anisotropy measurements reveal that the motor clusters, like filamentous microtubules, exhibit local nematic order. The properties of the DNA linker enable the design of force-sensing clusters. When the load across the linker exceeds a critical threshold, the clusters fall apart, ceasing to generate active stresses and slowing the system dynamics. Fluorescence readout reveals the fraction of bound clusters that generate interfilament sliding. In turn, this yields the average load experienced by the kinesin motors as they step along the microtubules. DNA-motor clusters provide a foundation for understanding the molecular mechanism by which nanoscale molecular motors collectively generate mesoscopic active stresses, which in turn power macroscale nonequilibrium dynamics of active nematics.

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Confinement-Induced Self-Pumping in 3D Active Fluids

Cited by 40 publications

References 55 publications

Vesicle shape transformations driven by confined active filaments

Vesicle shape transformations driven by confined active filaments

Vesicle shape transformations driven by confined active filaments

Active liquid crystals powered by force-sensing DNA-motor clusters

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