Confirmation of drug allergy in a general pediatrics outpatient clinic

Çapanoğlu, Murat; Erkoçoğlu, Mustafa; Kaya, Ayşenur; Mısırlıoğlu, Emine Dibek; Giniş, Tayfur; Toyran, Müge; Civelek, Ersoy; Kocabaş, Can Naci

doi:10.1016/j.anai.2022.09.017

Cited by 4 publications

(6 citation statements)

References 22 publications

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“…DHRs are most commonly reported with antibiotics and NSAIDs (15,19). In our study, antibiotics and NSAIDs were the most frequently reported suspicious drugs by families.…”

Section: Discussionsupporting

confidence: 49%

“…The true prevalence of DHRs in children is not clearly known because the results of several studies in the literature were not confirmed by drug allergy tests, implying some of these results may include drug side effects (15). While approximately 10% of parents report that their children have DHRs, DHRs can be confirmed in only a very small number of them with drug allergy tests (2).…”

Section: Discussionmentioning

confidence: 99%

“…The low frequency of confirmed DHRs in studies conducted in patients presenting with suspected DHRs emphasizes the importance of diagnostic drug tests (15,16). Because many untested children with suspected DHRs may be incorrectly identified with drug allergy labels, which may lead to the unnecessary use of broad-spectrum, less-effective, and/or more expensive medications.…”

Section: Discussionmentioning

confidence: 99%

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Characteristics of Drug Hypersensitivity Reactions in Children: A Retrospective Analysis in an Allergy Outpatient Clinic

Büyük Yaytokgil,

Vezir

2024

Türkiye Çocuk Hast Derg

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Objective: Confirmation of drug hypersensitivity reactions (DHRs) is crucial—as various nonallergic reactions, such as viral infections, in children can mimic such reactions. This study aimed to evaluate the characteristics of children with suspected DHRs applying to an allergy outpatient clinic. Material and Methods: This study involved children who visited our hospital’s pediatric allergy outpatient clinic between April 1 and December 31, 2023, with suspected DHRs . The data of patients analyzed retrospectively. Patient demographics, reaction characteristics, culprit drugs, diagnostic procedures (including skin and/or provocation tests), and final diagnoses were recorded. Results: The study included 163 reactions of 140 patients with 176 suspected drugs. The median age was 7.7 years (interquartile range [IQR]; 5.1–12 years), with an equal gender distribution. Notably, 27.1% of the patients presented with concurrent atopic diseases. The median age at the onset of reaction was 72 months (IQR; 34.5–108 months), with 16% of reactions occurring within hospital settings and the remainder at home. Oral administration accounted for 84.7% of the reactions, with antibiotics being the most common culprit drug group (75.5%). Immediate reactions constituted 41.1% (n = 67) of reactions, while delayed reactions accounted for 58.9% (n = 96). Skin symptoms were predominant (97.5%). DHRs were excluded in 75.5% (n = 123) of reactions but confirmed by diagnostic drug allergy tests in 4.9% (n = 8). Conclusion: A through evaluation of suspected DHRs in children is essential. Despite high suspicion rates, confirmation via diagnostic tests was low, emphasizing the need for referral to specialized clinics and appropriate diagnostics for accurate management.

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“…DHRs are most commonly reported with antibiotics and NSAIDs (15,19). In our study, antibiotics and NSAIDs were the most frequently reported suspicious drugs by families.…”

Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Characteristics of Drug Hypersensitivity Reactions in Children: A Retrospective Analysis in an Allergy Outpatient Clinic

Büyük Yaytokgil,

Vezir

2024

Türkiye Çocuk Hast Derg

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“…Recently, Capanoglu et al evaluated 5,553 children with suspected drug allergies ( 9 ). Parents were asked “Has your child ever developed any allergies after using drugs?”, and 7% (389) answered that their child had drug allergies.…”

Section: Epidemiology Of Drug Allergy In Childrenmentioning

confidence: 99%

“…After diagnostic tests, drug allergy was confirmed in 4.2% ( n = 3/72). Therefore, the frequency of suspected drug allergy was 1.47% ( n = 82/5553), and the prevalence of confirmed drug allergy was 0.05% ( n = 3/5,553) ( 9 ).…”

Section: Epidemiology Of Drug Allergy In Childrenmentioning

confidence: 99%

Recent findings on drug hypersensitivity in children

Felix,

Kuschnir,

Boechat

et al. 2024

Front. Allergy

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Drug hypersensitivity reactions (DHR) in children have a significant impact on clinical practice and public health. Both under-diagnosis (due to under-reporting) and over-diagnosis (due to the overuse of the term “allergy”) are potential issues. The aim of this narrative review is to describe the most recent findings of DHR in children/adolescents and gaps regarding epidemiology, antibiotic allergy, antiepileptic hypersensitivity, vaccine allergy, and severe cutaneous adverse reactions (SCAR) in this age group.

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