Confirmation of ethnopharmacological anti-inflammatory properties of Ocotea odorifera and determination of its main active compounds

Alcântara, Bianca Gonçalves Vasconcelos de; Oliveira, Felipe P. de; Katchborian-Neto, Albert; Casoti, Rosana; Domingos, Olívia da Silva; Santos, Mário F. C.; Oliveira, Rejane Barbosa de; Paula, Alessandro Vinícius de; Dias, Danielle Ferreira; Soares, Marisi G.; Chagas‐Paula, Daniela Aparecida

doi:10.1016/j.jep.2020.113378

Cited by 12 publications

(12 citation statements)

References 35 publications

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“…Amongst the most active extracts from G1, which inhibited PGE 2 production at more than 75 %, OD and OO extracts can be highlighted (Table 5S, Supporting Information ). Our results agreed with the in vivo anti‐inflammatory activities of O. diospyrifolia (OD) and O. odorifera (OO) in a mouse ear oedema model have been described in the literature [1,12] …”

Section: Resultssupporting

confidence: 91%

“…In addition, most of the metabolites were defined biomarkers for several Lauraceae species, particularly the alkaloid reticuline mainly for the genus Ocotea . Reticulin is a major compound of O. odorifera and was described to exhibit anti‐inflammatory activity by dual inhibition of COX and LOX pathways, which supported our findings [1] …”

Section: Resultssupporting

confidence: 90%

“…The family comprises mostly trees and shrubs, which are economically important and trendy in a wide range of industrial sectors that include food, wood exploitation, pharmaceutical, and perfume industries. In addition, several ethnobotanical studies have shown medical applications of Lauraceae species in multiple pathologies, such as in the treatment of neglected tropical infectious diseases such as malaria, exhibits an analgesic role in gastrointestinal infections, genital infections, and rheumatism, as well as a lot of potential amongst other several inflammatory conditions [1–3] . However, although they have the potential for anti‐inflammatory activity, most of the species were not investigated regarding this activity.…”

Section: Introductionmentioning

confidence: 99%

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Anti‐Inflammatory Activity of Lauraceae Plant Species and Prediction Models Based on Their Metabolomics Profiling Data

Alcântara

Katchborian-Neto

Garcia

et al. 2023

Chemistry & Biodiversity

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The Lauraceae is a botanical family known for its anti‐inflammatory potential. However, several species have not yet been studied. Thus, this work aimed to screen the anti‐inflammatory activity of this plant family and to build statistical prediction models. The methodology was based on the statistical analysis of high‐resolution liquid chromatography coupled with mass spectrometry data and the ex vivo anti‐inflammatory activity of plant extracts. The ex vivo results demonstrated significant anti‐inflammatory activity for several of these plants for the first time. The sample data were applied to build anti‐inflammatory activity prediction models, including the partial least square acquired, artificial neural network, and stochastic gradient descent, which showed adequate fitting and predictive performance. Key anti‐inflammatory markers, such as aporphine and benzylisoquinoline alkaloids were annotated with confidence level 2. Additionally, the validated prediction models proved to be useful for predicting active extracts using metabolomics data and studying their most bioactive metabolites.

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Anti‐Inflammatory Activity of Lauraceae Plant Species and Prediction Models Based on Their Metabolomics Profiling Data

Alcântara

Katchborian-Neto

Garcia

et al. 2023

Chemistry & Biodiversity

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“…Estudos com Ocotea odorifera (Vell.) Rohwer, planta muito utilizada na medicina tradicional no sul do Brasil para o tratamento de doenças relacionadas à inflamação, mostraram que diferentes frações de seu extrato etanólico demonstraram atividade anti-inflamatória por dupla inibição do edema e recrutamento de neutrófilos (Alcântara et al, 2021).…”

Section: Plantas Medicinais Com Atividade Anti-inflamatóriaunclassified

“…gênero Ocotea e são potencialmente anti-inflamatórios, uma dessas substâncias foi identificada como o alcaloide S -(+)reticulina, que foi relatado por apresentar atividade anti-inflamatória (Alcântara et al, 2021).…”

Section: Constituintes Químicos Responsáveis Pela Atividade Anti-inflamatóriaunclassified

Espécies medicinais do Brasil com potencial anti-inflamatório ou antioxidante: Uma revisão

Pereira

Martins

Rocha

et al. 2021

RSD

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As plantas medicinais são utilizadas pela população desde tempos imemoriais, representando uma fonte notável para o tratamento de diversas doenças humanas, que podem ter seu risco reduzido pela ingestão de produtos à base destas plantas, benefícios que são atribuídos a alguns metabólitos secundários que apresentam uma diversidade de atividades, dentre elas destacam-se a antiinflamatória e/ou antioxidante. O objetivo desse trabalho é realizar um levantamento bibliográfico buscando as espécies mais utilizadas de plantas medicinais do Brasil com potencial anti-inflamatório e antioxidante da última década. Foram utilizadas publicações indexadas nas bases de dados PubMed, Science Direct e Scielo nos últimos 10 anos, utilizando os seguintes descritores: “Brazilian medicinal plants”, “anti-inflammatory activity” e “antioxidant activity” Utilizando o marcador booleano “AND” assegurando a especificidade nas buscas. Foram identificados 1.185 artigos, onde 1.140 foram eliminados por não atenderem aos critérios de inclusão ou exclusão. O total de 45 artigos foram incluídos, categorizados de acordo com a utilização para atividade anti-inflamatória e atividade antioxidante. Dentre os compostos ativos com atividades anti-inflamatórias tem-se alguns compostos polifenólicos, além de alcalóide, terpenóide e esteróides. Estes metabólitos secundários atuam em diferentes alvos envolvidos no processo inflamatório. Os estudos têm demonstrado que os compostos polifenólicos, principalmente os flavonoides, apresentam propriedades antioxidantes que podem ser utilizados para fins terapêuticos em doenças como crônico-degenerativas. Esses resultados sugerem as perspectivas de estudos futuros para se obter uma melhor compreensão dos componentes individuais e o uso desses compostos como um possível agente terapêutico para patologias como a inflamação e aumento de radicais livres.

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High‐Resolution Tandem Mass Spectrometry for Metabolic Profiling of Ocotea diospyrifolia (Meisn.) Mez Leaves

Alves,

Katchborian Neto,

Casoti

et al. 2024

Chemistry & Biodiversity

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Ocotea is an important genus of Lauraceae plant family that comprises over 400 species, many of which pose challenges in taxonomic differentiation due to their complex botanical characteristics. Chemosystematics, and more recently, chemophenetics, have emerged as valuable tools to address these challenges based on their natural products (NPs) composition. O. diospyrifolia (Meisn.) Mez is a poorly studied species with known pharmacological potential. Here, we applied ultra‐high performance liquid chromatography coupled with high‐resolution tandem mass spectrometry (UHPLC‐HRMS) allied to a curated in‐house database with all previous isolated NPs from the Ocotea genus (OcoteaDB), gas phase fragmentations reactions, and biosynthesis. The strategy resulted in compounds annotated in confidence levels 2 (n=27), 3 (n=231), and 4 (n=21) according to the Metabolomics Standards Initiative (MSI). Additional annotations based on fragmentation proposals (n=16) were also included. The study revealed that O. diospyrifolia is a great alkaloid producer, even though different lignoids, which also comes from the shikimate pathway, were annotated. Additionally, the flavonoid profile predominantly consists of flavonol glycosides, complementing prior reports. This study provides the first comprehensive chemical profile of O. diospyrifolia leaves, which corroborates the chemotaxonomy of the species, and also contributes to further characterization studies, as the UHPLC‐HRMS data is publicly available.

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Confirmation of ethnopharmacological anti-inflammatory properties of Ocotea odorifera and determination of its main active compounds

Cited by 12 publications

References 35 publications

Anti‐Inflammatory Activity of Lauraceae Plant Species and Prediction Models Based on Their Metabolomics Profiling Data

Anti‐Inflammatory Activity of Lauraceae Plant Species and Prediction Models Based on Their Metabolomics Profiling Data

Espécies medicinais do Brasil com potencial anti-inflamatório ou antioxidante: Uma revisão

High‐Resolution Tandem Mass Spectrometry for Metabolic Profiling of Ocotea diospyrifolia (Meisn.) Mez Leaves

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