Confirmation of the Crucial Role of the Recipientʼs Maximal Hydration Onearly Diuresis of the Human Cadaver Renal Allograft

Carlier, Marianne; Squifflet, Jean‐Paul; Pirson, Yves; Decocq, L; Gribomont, Bernard; Alexandre, Guy P.

doi:10.1097/00007890-198310000-00021

Cited by 40 publications

(20 citation statements)

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“…The function and viability of the graft seem to be optimized if the perfusion is maximized. [2][3][4]7 This study confirms that the timing of crystalloid infusion makes a difference in clinical outcome. The biphasic hydration regimen applied in the CVPT group delayed most of the crystalloid administration until shortly before the renal vessels were unclamped.…”

Section: Discussionsupporting

confidence: 63%

“…The improvement in intraoperative diuresis and early postoperative graft function in our CVPT group are consistent with other studies evaluating the effect of maximal hydration on graft function and short-term success of renal transplant. 4,7,11,15,24,25 Many studies suggest that during renal transplantation, one should maintain the recipients systolic blood pressure Ͼ120 mm Hg, 8 diastolic blood pressure Ͼ85 mm Hg, 24 mean arterial blood pressure Ͼ95 mm Hg, 16 CVP Ͼ10 mm Hg, 5,25 and pulmonary artery pressure Ͼ20 mm Hg. 4,11 These values are intended to ensure maximal filling pressure of the graft and rapid recovery of graft function.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 Previous trials have also examined several hydration regimens for kidney transplantation using crystalloids, colloids, or both, in addition to mannitol or loop diuretics, to expand intravascular volume and promote diuresis. 4,[7][8][9] Crystalloids mostly distribute to the interstitial space whereas colloids mostly remain in the intravascular space. 10 Normal saline 0.9% is the most frequently administered crystalloid during renal transplant because it is devoid of potassium, minimizing the risk of electrolyteinduced cardiac dysrhythmias.…”

mentioning

confidence: 99%

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The Impact of Timing of Maximal Crystalloid Hydration on Early Graft Function During Kidney Transplantation

Othman

Ismael

Hammouda

2010

Anesthesia &Amp; Analgesia

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Hydration directed toward maintaining a given CVP during kidney transplantation produced a more stable hemodynamic profile and promoted diuresis. The calculated infusion rate of approximately 45 to 50 mL . min(-1), within an hour ischemia time, seems feasible to enhance early graft function. A larger trial with long-term follow-up of renal function is warranted to confirm the clinical benefit of titrating IV crystalloid administration to maintain a given CVP in this population.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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The Impact of Timing of Maximal Crystalloid Hydration on Early Graft Function During Kidney Transplantation

Othman

Ismael

Hammouda

2010

Anesthesia &Amp; Analgesia

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“…In 1983, Carlier et al. (23) found that IGF was associated with a higher pulmonary arterial pressure. Fluid volume intravenously infused during the first 72 h after transplantation was associated with DGF occurrence in the study of Van Biesen et al.…”

Section: Discussionmentioning

confidence: 99%

Hydration status of patients with end-stage renal disease after kidney transplantation

Gueutin

Ficheux

Châtelet

et al. 2011

Clinical Transplantation

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“…(20) Eventually, the use of excessive fluid infusion becomes of value to avoid the use of vasopressors (D). (21,22) However, no controlled or retrospective studies have been done that specifically address the ideal method of fluid replacement for deceased donors.…”

Section: Renal Maintenancementioning

confidence: 99%

Diretrizes para manutenção de múltiplos órgãos no potencial doador adulto falecido: Parte III. Recomendações órgãos específicas

Westphal¹,

Filho²,

Vieira³

et al. 2011

Rev. bras. ter. intensiva

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Brain death (BD) alters the pathophysiology of patients and may damage the kidneys, the lungs, the heart and the liver. To obtain better quality transplant organs, intensive care physicians in charge of the maintenance of deceased donors should attentively monitor these organs. Careful hemodynamic, ventilatory and bronchial clearance management minimizes the loss of kidneys and lungs. The evaluation of cardiac function and morphology supports the transplant viability assessment of the heart. The monitoring of liver function, the management of the patient's metabolic status and the evaluation of viral serology are fundamental for organ selection by the transplant teams and for the care of the transplant recipient. OBJECTIVEThese guidelines are aimed at contributing to the institutional coordination of organ transplantation and will provide "real world" guidelines that are appropriate in the Brazilian context for the uniform care of the deceased donor. Ultimately, this aim of this guide is to increase the quality and quantity of transplantable organs. METHODOLOGYThe Writing and Planning Committee, comprised of young intensive care physicians and intensive medicine residents, conducted an extensive literature review. From this review, they formulated questions and forwarded the questions to all of the authors of this article. These initial questions served as the starting point for receiving suggestions for the formulation of other questions and definitions.The final questions were revised by the Executive Committee and were returned to the authors to develop the guidelines presented in this article.The questions guided the literature review, which was conducted using the P.I.C.O. methodology where P stands for the target population, I for the intervention, C for the control or comparative group and O for the clinical outcome.The retrieved articles were critically analyzed and categorized according to their grade of recommendation and the strength of the presented evidence in the following manner:

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Confirmation of the Crucial Role of the Recipientʼs Maximal Hydration Onearly Diuresis of the Human Cadaver Renal Allograft

Cited by 40 publications

References 0 publications

The Impact of Timing of Maximal Crystalloid Hydration on Early Graft Function During Kidney Transplantation

The Impact of Timing of Maximal Crystalloid Hydration on Early Graft Function During Kidney Transplantation

Hydration status of patients with end-stage renal disease after kidney transplantation

Diretrizes para manutenção de múltiplos órgãos no potencial doador adulto falecido: Parte III. Recomendações órgãos específicas

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