Confirmation of the Diagnosis of Natural Rubber Latex Allergy by the Basotest&lt;sup&gt;®&lt;/sup&gt; Method

Hemery, M.-L.; Arnoux, B.; Dhivert‐Donnadieu, H.; Rongier, M.; Barbotte, E.; Verdier, Raymond; Démoly, P.

doi:10.1159/000082585

Cited by 35 publications

(16 citation statements)

References 31 publications

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“…Moreover, our results with DPT underline that false-positive results exist with CD63 as well as with CD203c. Up until recently, false-positive results in FC were unknown, they were described in the diagnosis of latex allergy [36].…”

Section: Discussionmentioning

confidence: 99%

Comparison of two basophil activation markers CD63 and CD203c in the diagnosis of amoxicillin allergy

Abuaf¹,

Rostane²,

Rajoely³

et al. 2008

Clin Experimental Allergy

117

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Section: Discussionmentioning

confidence: 99%

Comparison of two basophil activation markers CD63 and CD203c in the diagnosis of amoxicillin allergy

Abuaf¹,

Rostane²,

Rajoely³

et al. 2008

Clin Experimental Allergy

117

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“…Many of these studies have been reviewed recently [8,9,10]. Herewith, tables 1, 2, 3, 4, 5, 6, 7summarize the results of validated clinical studies performed with various allergens such as inhalant allergens [25,26,27,28,29,30,31,32,33] (table 1), hymenoptera venoms [34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56] (table 2), latex [57,58,59,60,61,62,63] (table 3), food [64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80] (table 4) and drugs [81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,…”

Section: Clinical Issues In the Diagnostic Use Of Batmentioning

confidence: 99%

“…In several validated studies [57,58,59,60,61,62,63] (table 3), BAT was shown to demonstrate a sensitivity and specificity for CD63 expression of >90%, with one exception in which sensitivity was reported to be 75% for CD203c and 50% for the CD63 assay [60]. BAT is the test which reflects the most closely clinical provocation.…”

Section: Clinical Indications Of Batmentioning

confidence: 99%

Diagnostic Tests Based on Human Basophils: More Potentials and Perspectives than Pitfalls

Weck

Sánz

Gamboa

et al. 2008

Int Arch Allergy Immunol

171

178

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For the diagnosis of allergy, cellular basophil activation tests (BAT), e.g. histamine or sulfidoleukotriene release tests, have long been introduced, but the expression of basophil activation markers such as CD63 and CD203c detected by flow cytometry has attracted more recent attention. A recent opinion paper in this Journal has stressed not only the potential but also the possible pitfalls of flow-cytometric BAT. We have applied clinical validation of various BAT in various ways for several years, and our experience shows that these new technologies have more potentials and perspectives than pitfalls. A comprehensive review of clinically validated studies on allergy to aeroallergens, insect venoms, latex, food allergens and drugs, e.g. myorelaxants, β-lactams, pyrazolones and non-steroidal anti-inflammatory drugs, as well as chronic urticaria shows clearly that even with different protocols, reproducible and meaningful results can be obtained. Although the available technologies may still be optimized and better standardized, there are no serious reasons to deprive allergic patients of clinically indicated BAT, which can be performed reliably by any laboratory with allergy and flow-cytometric capacity and expertise.

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“…In most patients, diagnosis of NRL anaphylaxis can readily be established by quantification of sIgE (k82), skin tests, or both (77)(78)(79). Although these tests are highly reliable, results of are not always unequivocal (80), and some patients might need additional tests such as basophil activation (81)(82)(83) or challenge tests (84,85) to establish diagnosis.…”

Section: Natural Rubber Latexmentioning

confidence: 99%

Anaphylaxis during anaesthesia: diagnostic approach

Ebo¹,

Fisher²,

Hagendorens³

et al. 2007

Allergy

195

197

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Anaesthesiologists administer several drugs while providing general anaesthesia. Many of these drugs can elicit adverse drug reactions that fall apart into two major types. First, reactions that are usually dose-dependent and related to the pharmacological properties of the drug and/or its metabolites. Second, reactions that are unrelated to the drug's pharmacological characteristics and that are less dose-dependent. These reactions comprise drug intolerance, idiosyncratic reactions and drug-induced immune-mediated allergic and nonimmune-mediated so-called pseudo-allergic or anaphylactoid reactions. The terms anaphylactic and anaphylactoid, however, have been used inconsistently in the literature. Therefore, the nomenclature task force set up by the European Academy of Allergy and Immunology (EAACI) has proposed that anaphylactic-type reactions should be reclassified into allergic anaphylaxis and nonallergic anaphylaxis. Allergic anaphylaxis being further subdivided in IgE-mediated and non-IgE-mediated reactions (1).The exact prevalence of anaphylaxis during anaesthesia is difficult to ascertain. The estimated overall frequency has been reported to vary between 1 in 3500 and 1 in 13 000 procedures in French series (2, 3) and between 1 in 10 000 and 1 in 20 000 in an Australian study (4). The clinical manifestation of these reactions is not infrequently an almost immediate generalized response with bronchospasm and hypotension. The degree of severity varies and does not allow differentiation between an IgE-mediated or non-IgE mediated reaction resulting from nonspecific mediator release (5). The mortality from these reactions is in the range from 3 to 6%, and an additional 2% of patients experience significant residual brain damage (4).Diagnosis of anaphylaxis during anaesthesia is not always straightforward. It can be hampered as a broad spectrum of different drugs can elicit heterogeneous allergic and nonallergic reactions with distinct and sometimes unclear pathological mechanisms. Problems are certainly compounded as multiple drugs need to be administered during general anaesthesia. In addition, nonanaesthesia related drugs or procedures (e.g. disinfection) are sometimes administered/performed in the perioperative period and can also be the cause of an allergic reaction.In addition, none of the available diagnostic tests demonstrates absolute accuracy. False-positive test Correct management of anaphylaxis during anaesthesia requires a multidisciplinary approach with prompt recognition and treatment of the acute event by the attending anaesthesiologist, and subsequent determination of the responsible agent(s) with strict avoidance of subsequent administration of all incriminated and/or cross-reacting compounds.However, correct identification of the causative compound(s) and safe alternatives is not always straightforward and, too often, not done.This review is not intended to discuss acute management of anaesthesia-related anaphylaxis but summarizes the major causes of anaphylaxis during anaesthesia and the di...

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Confirmation of the Diagnosis of Natural Rubber Latex Allergy by the Basotest<sup>®</sup> Method

Cited by 35 publications

References 31 publications

Comparison of two basophil activation markers CD63 and CD203c in the diagnosis of amoxicillin allergy

Comparison of two basophil activation markers CD63 and CD203c in the diagnosis of amoxicillin allergy

Diagnostic Tests Based on Human Basophils: More Potentials and Perspectives than Pitfalls

Anaphylaxis during anaesthesia: diagnostic approach

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