Confirmation of the systematic presence of tin particles in fallopian tubes or uterine horns of Essure implant explanted patients: A study of 18 cases with the same pathological process

Catinon, Mickaël; Roux, E.; Auroux, A.; Trunfio-Sfarghiu, Ana-Maria; Lauro-Colleaux, C.; Watkin, E. M.; Sournies, G.; Vincent, Michel

doi:10.1016/j.jtemb.2021.126891

Cited by 11 publications

(1 citation statement)

References 53 publications

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“…Patients tend to present with secondary infertility rather than acute infective pathology [13][14][15][16][17] and for this reason, may elude medical care for many years beyond the exposure event [18]. As in our case, definitive management requires surgical removal of the foreign body [19][20][21][22] to restore normal endometrial implantation potential and inflammatory risk profile. Having done so, return to normal fertility is an immediate and for many, a much sought-after boon of successful care.…”

Section: Discussionmentioning

confidence: 99%

Thorn in my Side - A Case of Entrapped, Intra-uterine Foreign Body and Delayed, Atypical Pelvic Inflammatory Disease

Aboda¹,

Kim²,

Xu³

et al. 2022

austinjclincaserep

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Uterine foreign bodies are a rare, but important cause of infertility and pelvic pain. Due to their relative scarcity, the diagnosis may be either missed or simply not considered as contributory to aetiology when patients present with symptoms. We report the case of a 42-year-old woman diagnosed with Atypical Pelvic Inflammatory Disease (APID). She presented with lower abdominal pain, vaginal discharge and inflammatory markers consistent with acute infection. Paradoxically, diagnostic imaging revealed an unsuspected intrauterine foreign body. The significance of this to the presenting complaint was initially uncertain however conservative management with antibiotics alone was sufficient to allow complete recovery. Later, the patient consented to operative hysteroscopy which identified and removed the object which was shown by histology to be a residual bone fragment derived most probably, from retained products of conception. The patient was noted to have had a surgical termination of pregnancy 5 years prior.

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Section: Discussionmentioning

confidence: 99%

Thorn in my Side - A Case of Entrapped, Intra-uterine Foreign Body and Delayed, Atypical Pelvic Inflammatory Disease

Aboda¹,

Kim²,

Xu³

et al. 2022

austinjclincaserep

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Cornual adenomyosis in Essure® device users and in patients hysterectomized for other causes: A retrospective cohort study

Sánchez‐Cuerda,

Elices,

Lobo

et al. 2024

Intl J Gynecology & Obste

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ObjectiveTo determine whether adenomyosis is present in the cornual portion of hysterectomies of symptomatic sterilization device users and in patients hysterectomized for different benign causes and who presented with pelvic pain and/or menstrual alterations.MethodsAn observational, analytical, cross‐sectional, single‐center, retrospective cohort study was conducted in a secondary level hospital. Cohort 1 consisted of women who had Essure® hysteroscopic sterilization devices inserted between 2009 and 2017, who developed gynecologic symptoms (pelvic pain, heavy menstrual bleeding, and/or abnormal uterine bleeding) and who underwent a hysterectomy for explantation of the devices. Cohort 2 consisted of women with the same gynecologic symptoms, who underwent a hysterectomy for other benign causes. All surgeries were performed by the gynecology team between 2018 and 2022. A descriptive and comparative analysis of sociodemographic, clinical characteristics, and pathologic findings between cohorts was made.ResultsIn total, 96 patients were studied (cohort 1 included 34 women, cohort 2 included 62 women). Pelvic pain was found to be more frequent in the cohort of Essure users (76.47% vs. 50%, P = 0.012), with a ratio of three times higher in this group (odds ratio 3.25, 95% confidence interval 1.27–8.28). Adenomyosis was more frequently found in the Essure group, both at corporal and cornual portions, the latter being five times higher in this cohort (relative risk = 5.47; 95% confidence interval 1.17–25.64).ConclusionsThe present study may be the first to describe cornual adenomyosis related to Essure devices. These devices may play a role in the development of adenomyosis and, consequently, pelvic pain. However, causality is difficult to establish.

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Letter to the Editor: Cornual adenomyosis in Essure® device users and in patients hysterectomized for other causes—A retrospective cohort study

Chene,

Parant,

Devouassoux‐Shisheboran

et al. 2024

Intl J Gynecology & Obste

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G y n e c o l o g y Letter to the Editor: Cornual adenomyosis in Essure® device users and in patients hysterectomized for other causes-A retrospective cohort study Dear Editor, We have read with great interest the article entitled "Cornual adenomyosis in Essure® device users and in patients hysterectomized for other causes: a retrospective cohort study" in which the authors hypothesize that there is a relationship between cornual adenomyosis and Essure® devices. 1 The authors found a rate of corporal adenomyosis in 21/34 (61.76%) patients and a rate of cornual adenomyosis in 6/34 (17.65%) patients (Essure® group n = 34). 1 They raised the question of an iatrogenic injury induced by the Essure® implants leading to a specific mechanism called tissue injury and repair (TIAR): this damage may trigger hyperperistalsis of the uterine muscle fibers leading to cornual adenomyosis and subsequently chronic pelvic pain and heavy menstrual bleeding, as explained in the model developed by Leyendecker et al.2

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Confirmation of the systematic presence of tin particles in fallopian tubes or uterine horns of Essure implant explanted patients: A study of 18 cases with the same pathological process

Cited by 11 publications

References 53 publications

Thorn in my Side - A Case of Entrapped, Intra-uterine Foreign Body and Delayed, Atypical Pelvic Inflammatory Disease

Thorn in my Side - A Case of Entrapped, Intra-uterine Foreign Body and Delayed, Atypical Pelvic Inflammatory Disease

Cornual adenomyosis in Essure® device users and in patients hysterectomized for other causes: A retrospective cohort study

Letter to the Editor: Cornual adenomyosis in Essure® device users and in patients hysterectomized for other causes—A retrospective cohort study

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