Confirmed efficacy of topical nifedipine in the treatment of facial wrinkles

Calabrò, Gabriella; Vita, Valerio De; Patalano, Angela; Mazzella, Caterina; Conte, Viviana Lo; Antropoli, Carmine

doi:10.3109/09546634.2013.802759

Cited by 15 publications

(14 citation statements)

References 16 publications

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“…The different subjective methods used included photographs, patient satisfaction or/and physician global assessment, the WSRS, the GAIS and a visual analogue scale (VAS). For example in the study by Calabaro et al [9], the WSRS was combined with the use of a corneometer, tewameter and cutometer to assess facial wrinkle improvement after topical application of nifedipine. Overall, the WSRS is used to assess the efficacy of different hyaluronic acid formulations on nasolabial folds in combination with 3D imaging or reflectance confocal microscopy (RCM) [10,11].…”

Section: Objective Methods To Assess Facial Rejuvenation Treatmentmentioning

confidence: 99%

“…Seven studies (19 % of reviewed studies using quantitative methods) used a corneometer to assess the efficacy of an anti-wrinkle treatment, photoageing and periorbital dark circles on skin hydration [9,23,33]. Mehryan et al [38] measured stratum corneum hydration after platelet-rich plasma injections.…”

Section: Corneometermentioning

confidence: 99%

“…Among these articles, 8 articles used the WSRS to assess the efficacy of different hyaluronic acid formulations on the correction of nasolabial folds (Table 1). To assess wrinkle severity, Calabaro et al [9] have investigated the WSRS which was used by blinded investigators and reported that this scale is a valid quantitative assessment with good intra-and interobserver agreement. Furthermore, Choi and collaborators, using only subjective methods, have shown that it is important to validate the treatment assessment by developing objective methods [4].…”

Section: Wrinkle Severity Rating Scale (Wsrs)mentioning

confidence: 99%

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Assessment Tools for Facial Rejuvenation Treatment: A Review

et al. 2016

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Section: Objective Methods To Assess Facial Rejuvenation Treatmentmentioning

confidence: 99%

Section: Corneometermentioning

confidence: 99%

Section: Wrinkle Severity Rating Scale (Wsrs)mentioning

confidence: 99%

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Assessment Tools for Facial Rejuvenation Treatment: A Review

et al. 2016

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“…Topical nifedipine is used for various purposes, such as treatment of periocular and face wrinkles (Innocenti et al, 2010;Calabro et al, 2014), closure of anal fissures (Golfam et al, 2010;Katsinelos et al, 2006), and particularly to promote healing of skin wounds (Smith 2010;Melo et al, 2008;Ebadi et al, 2003). Nifedipine (NFD) is a calcium channel blocker and its use was first recommended for treatment of cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Promotion of cutaneous penetration of nifedipine for nanoemulsion

Arantes

Santos

Freitas

et al. 2017

Braz. J. Pharm. Sci.

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This article reports the development and characterization of a nanoemulsion (NE) able to improve the cutaneous penetration of nifedipine. NE with nifedipine was development and characterized, presenting droplet size of 20 nm with low polydispersity index (IP<0.1), spherical shape without aggregation, pH compatible with typical skin levels and stability evaluated by seven months. In the permeation studies, a classical formulation based in an oil/water cream containing nifedipine was used for comparison with NE. Nanoemulsion promoted and improved the retention of nifedipine in the epidermis and dermis in relation to classical formulation. This promoting effect is related to the nanometric size of the droplets of the NE (20 nm), which give him a large superficial area, favoring the contact of the nanocarrier with the skin surface. The NE was efficient in promoting accumulation of nifedipine in the dermis, which is the site of vasodilation action. NE was not irritating according to the primary dermal irritation tests. NE is a promising release system to promote cutaneous penetration of nifedipine and can be used in the future in clinical trials to promote healing of lesions caused by peripheral vascular diseases.

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“…4,5) Specifically, topical application of nifedipine for 90 d was effective for reducing the depth of wrinkles and improving transepidermal water loss (TEWL) as a measure of disruption of the epidermal barrier. In mice with epidermal barrier disruption induced by acetone, nifedipine accelerated the recovery of TEWL.…”

mentioning

confidence: 99%

Nifedipine Prevents Sodium Caprate-Induced Barrier Dysfunction in Human Epidermal Keratinocyte Cultures

Uchino

Matsumoto

Watanabe

et al. 2015

Biological & Pharmaceutical Bulletin

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Tight junctions (TJs) of the epidermis play an important role in maintaining the epidermal barrier. TJ breakdown is associated with skin problems, such as wrinkles and transepidermal water loss (TEWL). Clinical studies have reported that topical nifedipine is effective in reducing the depth of wrinkles and improving TEWL. However, it remains unknown whether nifedipine influences the TJ function in the epidermis. In the present study, we investigated the effect of nifedipine on epidermal barrier dysfunction in normal human epidermal keratinocytes (NHEKs) treated with sodium caprate (C10), a TJ inhibitor. Nifedipine reversed the C10-decreased transepithelial electrical resistance values as a measure of disruption of the epidermal barrier. Immunocytochemical observations revealed that nifedipine improved the C10-induced irregular arrangement of claudin-1, a key protein in TJs. Taken together, these findings suggest that nifedipine prevents epidermal barrier dysfunction, at least in part, by reconstituting the irregular claudin-1 localization at TJs in C10-treated NHEKs.Key words epidermal barrier function; nifedipine; sodium caprate; transepithelial electrical resistance; normal human epidermal keratinocyte Skin is the interface between air and water, and provides a barrier function that prevents invasion of toxic or infectious substances and escape of moisture.1,2) Disruption of the skin barrier results in not only several pathological conditions, such as atopic dermatitis, but also cosmetic problems, such as dry skin, aged skin, and acne.2,3) The most important skin barrier function is the physical barrier. This barrier is maintained by the lipid bilayer in the stratum corneum, the acidic pH of the epidermis, a calcium gradient that influences cellular turnover and differentiation of the epidermis, and tight junctions (TJs) formed by cells of the granular layer.1,2) Breakdown of each component produces hyperpermeability of the epidermis, leading to a variety of dermatological symptoms and signs.Recently, clinical studies have reported the efficacy of topical nifedipine for the treatment of facial wrinkles.4,5) Specifically, topical application of nifedipine for 90 d was effective for reducing the depth of wrinkles and improving transepidermal water loss (TEWL) as a measure of disruption of the epidermal barrier. In mice with epidermal barrier disruption induced by acetone, nifedipine accelerated the recovery of TEWL.6) These reports suggest that nifedipine is useful for facilitating epidermal barrier maintenance, although its mechanisms remain obscure.Sodium caprate (C10), an epithelial transport enhancer, is known to disrupt not only the epithelial barrier, but also the epidermal barrier, resulting in hyperpermeability. 7) C10 decreases the transepithelial electrical resistance (TER) values by disrupting the arrangement of TJ proteins, such as claudin-1 and occludin, in cultured keratinocytes.7) Considering that claudin-1-deficient mice show wrinkled skin and TEWL, 8) C10-treated keratinocytes in culture are tho...

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Confirmed efficacy of topical nifedipine in the treatment of facial wrinkles

Abstract: The tested topical preparation is effective in reducing facial wrinkles' depth and in increasing skin hydration and elasticity.

Cited by 15 publications

References 16 publications

Assessment Tools for Facial Rejuvenation Treatment: A Review

Assessment Tools for Facial Rejuvenation Treatment: A Review

Promotion of cutaneous penetration of nifedipine for nanoemulsion

Nifedipine Prevents Sodium Caprate-Induced Barrier Dysfunction in Human Epidermal Keratinocyte Cultures

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