Large multinational teams of academics and activist-practitioners that span the Global North-South divide have become common in qualitative research because of the reliance of field of peace and conflict studies on “local” knowledge and expertise. Complex global emergencies, such as the COVID-19 pandemic, present the opportunity to (re)shape and (re)consider these endeavors in key some ways. This article focuses on the involvement of South-based activist-practitioners in three large North-South collaborations, one pre-pandemic (Beyond Words: Implementing Latin American Truth Commission Recommendations), one ongoing when the pandemic began (Gender, Justice, and Security Hub), and one launched during the pandemic (Truth Commissions and Sexual Violence: African and Latin American Experiences). Drawing on center-periphery framework, we adopt an autoethnographic approach, to reflect on how the pandemic has not only reinforced existing structural and institutional asymmetries through reduced funding, professional uncertainty, and personal loss and insecurity but also added some new ethical concerns. This reality has tested both our capacity and commitment to work toward the decolonization of knowledge in the field. In making this argument, we seek to contribute to the discussion on research ethics and the politics of knowledge production and sharing in qualitative peace and conflict research.