Conflicting effects of BMI and waist circumference on iron status

Choma, Solomon; Alberts, Marianne; Modjadji, Sewela Elizabeth Perpetua

doi:10.1016/j.jtemb.2015.06.003

Cited by 16 publications

(17 citation statements)

References 35 publications

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“…Most studies did not take women's BMI into account; a variable known to be inversely related with ferritin levels and thus increasing the prevalence of ID (13). In our study, however, no correlation between BMI and ferritin levels was obtained and the prevalence of obesity was comparable between women with and without ID.…”

Section: Discussioncontrasting

confidence: 86%

Prevalence of thyroid autoimmunity and dysfunction in women with iron deficiency during early pregnancy: is it altered?

Veltri¹,

Decaillet²,

Kleynen³

et al. 2016

European Journal of Endocrinology

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Objective: Thyroid disorders and iron deficiency (ID) are associated with obstetrical and fetal complications. Iron is essential for the normal functioning of thyroid peroxidase (TPO-abs) and ID is frequent during pregnancy. The aim of this study was to compare the prevalence of thyroid autoimmunity (TAI) and dysfunction during the first trimester of pregnancy in women with and without ID. Design: Cross-sectional data analysis of 1900 pregnant women nested within an ongoing prospective collection of pregnant women's data. Method: The study was performed in a single, tertiary referral center. During the first antenatal visit, ferritin, TPO-abs, thyroid-stimulating hormone (TSH) and free T 4 (FT 4 ) were measured and age and BMI were recorded. ID was defined as ferritin <15 µg/L, TAI when TPO-abs was >60 kIU/L, and subclinical hypothyroidism (SCH) when TSH was >2.5 mIU/L. Results: ID was present in 35% of women. Age and BMI were comparable between both groups. In the ID group, the prevalence of TAI and SCH was significantly higher, compared with that in the non-ID group (10% vs 6% and 20% vs 16%; P = 0.011 and 0.049 respectively). Ferritin was inversely correlated with serum TSH (ρ = −0.076; P = 0.001) and positive with FT 4 levels (ρ = 0.112; P < 0.001). In the logistic regression model, ID remained associated with TAI after correction for confounding factors (P = 0.017). The association with SCH was absent after correction for the confounders in the logistic regression model (P = 0.082), but remained present in the linear regression model (P = 0.035). Conclusions: ID was frequent during the first trimester of pregnancy and was associated with a higher prevalence of TAI, higher serum TSH, and lower FT 4 levels.

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Section: Discussioncontrasting

confidence: 86%

Prevalence of thyroid autoimmunity and dysfunction in women with iron deficiency during early pregnancy: is it altered?

Veltri¹,

Decaillet²,

Kleynen³

et al. 2016

European Journal of Endocrinology

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“…In a study with 905 women and 225 men, 21 Choma et al showed that BMI is negatively associated with ferritin concentration, and WC is positively but not significantly associated. The authors of this study suggested that in women, BMI is associated with low ferritin concentrations, while WC is related to increased ferritin levels.…”

Section: Discussionmentioning

confidence: 98%

“…The authors of this study suggested that in women, BMI is associated with low ferritin concentrations, while WC is related to increased ferritin levels. 21 Shim et al 22 investigated 15,963 Korean men and women between 2005 and 2011 and found that both IR and abdominal obesity were augmented across the ferritin levels quartiles after adjustment for sex. Furthermore, they found that the risk of MS was augmented across the ferritin quartiles in men and women.…”

Section: Discussionmentioning

confidence: 99%

<p>Association of Metabolic Syndrome and Hyperferritinemia in Patients at Cardiovascular Risk</p>

Togfano

Pescinni-Salzedas

Chagas

et al. 2020

DMSO

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Aim: To evaluate the association between parameters of hyperferritinemia (HF) and metabolic syndrome (MS) in patients at cardiovascular risk. Patients and Methods: This is a cross-sectional analytical observational study that included 269 patients who attended a cardiology unit. Biochemical and anthropometric parameters were evaluated to identify the presence of HF and MS. The presence of MS was evaluated according to NCEP ATP III. Biochemical parameters (glycemia, triglycerides, HDL-c) were assessed according to the manufacturer's protocols. Anthropometric measurements and blood pressure measurements were made by a trained professional. The chi-square (X 2) test, odds ratio, normality distribution (verified by the Kolmogorov-Smirnov test), and Levene's test were used to analyze the variables. To evaluate the effect of MS, HF, and the interaction between MS and HF, two-way analysis of variance (ANOVA) was performed based on the homogeneity of the variances, followed by Bonferroni's post hoc comparisons. Spearman correlation analysis was performed to evaluate the relationship between quantitative variables. A multiple linear regression model was used to analyze the effect of covariables. A logistic regression model was built to analyze the variables that contribute significantly to predict the outcome (HF) using the backward method. Results: Our results showed that 57% of men and 49.5% of women presented with MS; 44% of men and 11% of women presented with HF. The presence of MS and hypertriglyceridemia increase the probability of having HF by up to 2.1 and 1.88 times, respectively, while for male sex it is increased by 6.2 times. Patients with HF have higher values of C-reactive protein, ferritin, and transferrin saturation, regardless of the presence of MS. The linear regression analysis model indicated that the variables considered in this study explain less than 30% of the variation in ferritin and that the presence of MS in men is responsible for 22% of the variation in the probability of the occurrence of HF. Conclusion: Our results show that hyperferritinemia is closely associated with the components of MS (positive correlation with glycemia, triglycerides levels, blood pressure, and waist circumference, and negative correlation with HDL-c values) in the studied population.

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“…Dos parâmetros antropométricos analisados no presente estudo, encontrou-se relação significativa positiva somente entre RCQ com hemoglobina e hematócrito dos pais. Autores já haviam encontrado relação, porém negativa, de IMC e hemoglobina em sul-africanos; entretanto, encontrando relação positiva entre CC e hemoglobina 14 . Outros autores não encontraram relação da CC e do IMC com parâmetros hematológicos em italianos, mas após um ajuste com as variáveis sexo, idade e o hábito de fumar, encontraram uma relação positiva entre eles, o que foi atribuído à gordura abdominal e marcadores de resistência à insulina 6 .…”

Section: Discussionunclassified

Relação Entre Indicadores Antropométricos E Hematológicos De Pais E Seus Filhos

et al. 2017

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RESUMOObjetivo: Verificar possível associação entre o perfil hematológico e o estado nutricional de trabalhadores e seus filhos. Metodologia: Estudo transversal composto por 25 pais e seus respectivos filhos (25). Avaliou-se índice de massa corporal (IMC), circunferência da cintura (CC), circunferência do quadril (CQ) e relação cintura-quadril (RCQ). Para os indicadores hematológicos, avaliou-se a hemoglobina e o hematócrito. Resultados: 13 pais e 6 filhos apresentam sobrepeso/obesidade e 9 pais e 3 filhos apresentam CC elevada. Entre os filhos, 11 apresentam hemoglobina aumentada e 7 hematócrito aumentado. Não foi observada relação entre os indicadores antropométricos e hematológicos de pais e seus filhos. Com relação aos pais, observou-se relação significativa entre RCQ com hemoglobina (p=0,002) e hematócrito (p=0,020). Entre os filhos, a CC associou-se com a hemoglobina (p=0,046) e com o hematócrito (p=0,016). Conclusão: Não foi encontrada relação dos indicadores antropométricos e hematológicos entre pais e filhos. Por outro lado, os indicadores antropométricos e hematológicos mostraram associação nos pais e nos filhos .Descritores: Anemia; Obesidade; Adulto; Criança; Adolescente. RELAÇÃO ENTRE INDICADORES ANTROPOMÉTRICOS E HEMATOLÓGICOS DE PAIS E SEUS FILHOS RELATIONSHIP BETWEEN ANTHROPOMETRIC AND HEMATOLOGICAL INDICATORS OF PARENTS AND THEIR CHILDRENABSTRACT Objective: To verify the possible association between hematological profile and nutritional status of workers and their children. Methodology: Cross-sectional study composed of 25 parents and their respective children (25). Body mass index (BMI), waist circumference (WC), hip circumference (HR) and waist-hip ratio (WHR) were evaluated. For hematological indicators, hemoglobin and hematocrit were evaluated. Results: 13 fathers and 6 children were overweight/obese and 9 fathers and 3 children had elevated WC. Among children, 11 have increased hemoglobin and 7 increased hematocrit. There was no relation between the anthropometric and hematological indicators of parents and their children. Regarding the parents, there was a significant relationship between WHR with hemoglobin (p = 0.002) and hematocrit (p = 0.020). Among children, CC was associated with hemoglobin (p = 0.046) and hematocrit (p = 0.016). Conclusion: No correlation was found between anthropometric and hematological indicators between parents and children.

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Conflicting effects of BMI and waist circumference on iron status

Cited by 16 publications

References 35 publications

Prevalence of thyroid autoimmunity and dysfunction in women with iron deficiency during early pregnancy: is it altered?

Prevalence of thyroid autoimmunity and dysfunction in women with iron deficiency during early pregnancy: is it altered?

<p>Association of Metabolic Syndrome and Hyperferritinemia in Patients at Cardiovascular Risk</p>

Relação Entre Indicadores Antropométricos E Hematológicos De Pais E Seus Filhos

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