Conflicting guidelines: a commentary on the recent European Society for Emergency Medicine and European Society of Anaesthesiology and Intensive Care guidelines on temperature control after cardiac arrest

Andersen, Lars W.; Holmberg, Mathias J.; Nolan, Jerry P.; Soar, Jasmeet; Granfeldt, Asger

doi:10.1097/eja.0000000000002006

European Journal of Anaesthesiology

2024

DOI: 10.1097/eja.0000000000002006

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Conflicting guidelines: a commentary on the recent European Society for Emergency Medicine and European Society of Anaesthesiology and Intensive Care guidelines on temperature control after cardiac arrest

Lars W. Andersen,

Mathias J. Holmberg,

Jerry P. Nolan

et al.

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2024

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Does targeted temperature management at 33 °C improve outcome after cardiac arrest?

Skrifvars,

Abella

2024

Current Opinion in Critical Care

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Purpose of review Following successful resuscitation from cardiac arrest, a complex set of pathophysiologic processes are acutely triggered, leading to substantial morbidity and mortality. Postarrest management remains a major challenge to critical care providers, with few proven therapeutic strategies to improve outcomes. One therapy that has received substantial focus is the intentional lowering of core body temperature for a discrete period of time following resuscitation. In this review, we will discuss the key trials and other evidence surrounding TTM and present opposing arguments, one ‘against’ the use of postarrest TTM and another ‘for’ the use of this therapeutic approach. Recent findings Targeted temperature management, has been a topic of enormous controversy, as recently a number of clinical trials show conflicting results on the effect of TTM. Fundamental questions, about the dosing of TTM (e.g. use at 33 °C versus higher temperatures), or the use of TTM at all (as opposed to passive fever avoidance), remain active topics of global discussion. Systematic reviews on this topic also show variable results. Summary There are several arguments for and against the use of TTM targeting 33 °C for alleviating brain injury after cardiac arrest. More studies are on the way that will hopefully provide more robust evidence and hopefully allow for consensus on this important topic.

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Does targeted temperature management at 33 °C improve outcome after cardiac arrest?

Skrifvars,

Abella

2024

Current Opinion in Critical Care

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show abstract

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Conflicting guidelines: a commentary on the recent European Society for Emergency Medicine and European Society of Anaesthesiology and Intensive Care guidelines on temperature control after cardiac arrest

Cited by 1 publication

References 41 publications

Does targeted temperature management at 33 °C improve outcome after cardiac arrest?

Does targeted temperature management at 33 °C improve outcome after cardiac arrest?

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