Confocal laser endomicroscopy in gastrointestinal diseases

Goetz, Martin; Watson, Alastair; Kießlich, Ralf

doi:10.1002/jbio.201100022

Cited by 67 publications

(34 citation statements)

References 54 publications

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“…Both have been evaluated as endoscopeintegrated and probe-based devices. [7][8][9][10][11] Probes can be used more flexibly with most of the new generation highdefinition endoscopes. These probes are available 'on demand' for introduction through the working channel without the need for a dedicated endoscope.…”

Section: Introductionmentioning

confidence: 99%

Microscopic imaging in endoscopy: endomicroscopy and endocytoscopy

Goetz

Malek

Kießlich

2013

Nat Rev Gastroenterol Hepatol

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Performing real-time microscopy has been a vision of endoscopists since the very early phases of gastrointestinal endoscopy. Confocal endomicroscopy, an adaption of confocal laser scanning microscopy, and endocytoscopy, an adaption of white-light microscopy, have been introduced into the endoscopic armamentarium in the past decade. Both techniques yield on-site histological information. Multiple trials have demonstrated the ability of gastroenterologists to obtain and interpret microscopic images from the upper and lower gastrointestinal tract, and also the hepatobiliary-pancreatic system, during endoscopy. Such microscopic information has been successfully used in expert hands to minimize sampling error by 'smart', microscopically targeted biopsies and to guide endoscopic interventions. However, endomicroscopy is also unique in its ability to dynamically visualize cellular processes in their native environment free of artefacts. This ability enables fundamental insights into mechanisms of human diseases in clinical and translational science.

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Section: Introductionmentioning

confidence: 99%

Microscopic imaging in endoscopy: endomicroscopy and endocytoscopy

Goetz

Malek

Kießlich

2013

Nat Rev Gastroenterol Hepatol

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“…CLE allows high-resolution, microanatomical analysis of tissue ('optical biopsies') in real time during endoscopy [1,2]. The utility of this new technology is highlighted by its capacity to differentiate tissue types and entities on the basis of histologic characteristics of the mucosa and submucosal vasculature [3].…”

Section: Introductionmentioning

confidence: 99%

Confocal laser endomicroscopy in head and neck cancer

Volgger¹,

Conderman

Betz³

2013

Current Opinion in Otolaryngology & Head and Neck Surgery

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Purpose of reviewConfocal laser endomicroscopy (CLE) is a novel, noninvasive technique used to obtain microanatomical images of the inner lining of hollow organs. It has been used in a variety of clinical specialties to aid in the diagnosis and treatment planning of inflammatory and neoplastic processes. Our intent is to provide an up-to-date review of the literature in the setting of head and neck diseases as well as describing our own initial results and areas of future research. Recent findingsWith increasing experience using CLE in the upper aerodigestive tract (UADT), evidence is mounting that this method can be a useful adjunct to standard endoscopy and other diagnostic techniques. Recent publications have shown that by using CLE, microanatomical structures of healthy and diseased mucosa can easily be identified, allowing for a differentiation of dysplastic/neoplastic and benign mucosal lesions. Standardized diagnostic protocols as well as clinically relevant classification systems for the UADT have not yet been described. SummaryCLE is an imaging modality that allows real-time visualization of mucosal cellular architecture and other histologic characteristics. First reports on its use in the UADT have yielded promising results, but the true value of this method is yet to be determined.

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“…Since the first description in 2004 [1], the number of diseases studied with this technique has been steadily growing [2][3][4][5][6][7][8][9]. Trials with CLE have moved from feasibility studies in different parts of the endoscopically accessible areas of the gastrointestinal tract towards inflammatory and (pre-) neoplastic diseases that are often only incompletely appreciated by random biopsies.…”

Section: Introductionmentioning

confidence: 99%

Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review

Goetz

2012

ISRN Pathology

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Confocal laser endomicroscopy (CLE) is a novel tool in the endoscopist's armamentarium. It allows on-site histological information. The ability of gastroenterologists to interpret such microscopic information has been demonstrated in multiple studies from the upper and lower gastrointestinal tract. Recently, the field of application has expanded to provide hepatobiliary and intra-abdominal CLE imaging. CLE allows "smart," targeted biopsies and is able to guide endoscopic interventions. But CLE is also translational in its approach and permits functional imaging that significantly impacts on our understanding of gastrointestinal diseases. Molecular imaging with CLE allows detection and characterization of lesions and may even be used for prediction of response to targeted therapy. This paper provides a comprehensive review over current applications of CLE in clinical applications and translational science.

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Confocal laser endomicroscopy in gastrointestinal diseases

Cited by 67 publications

References 54 publications

Microscopic imaging in endoscopy: endomicroscopy and endocytoscopy

Microscopic imaging in endoscopy: endomicroscopy and endocytoscopy

Confocal laser endomicroscopy in head and neck cancer

Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review

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