Confocal laser method for quantitative evaluation of critical optical properties of toric intraocular lenses

Walker, Bennett N.; James, Robert H.; Calogero, Don; Ilev, Ilko K.

doi:10.1016/j.jcrs.2015.09.031

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Recently, our group has developed and implemented test methodologies to measure dioptric power of various IOL designs with high precision. [4][5][6][7] However, despite their significance in IOL characterization, 8 conventional techniques employed for IOL thickness and refractive-index measurements show some specific drawbacks and limitations in precise IOL testing. For instance, the use of simple mechanical devices such as vernier calipers or micrometers for IOL thickness measurement can affect the IOL optical quality caused by the contact measurement, and the lens curvature introduces additional inaccuracies for precise measurement.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the development and implementation of alternative noncontact sensing principles and measurement methods using remote, contact-free optical, or ultrasound irradiation sources have been considered to provide safer, more effective, and higher measurement accuracy approaches. 3,7 The use of optical measurement tools is especially attractive due to the well-developed optical imaging, microscopic, and sensing techniques providing high measurement accuracy.…”

Section: Introductionmentioning

confidence: 99%

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Noncontact method for sensing thickness and refractive index of intraocular lens implants using a self-calibrating dual-confocal laser caliper

Kim

James

Calogero³

et al. 2018

J. Biomed. Opt.

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We present a fiber-optic dual-confocal laser caliper method for noncontact high-precision sensing and measuring thickness and refractive index of intraocular lens (IOL) implants. The principle of the method is based on sensing and measuring the confocal intensity response of the laser beam reflection from the opposite object surfaces, which provides the advanced feature of having no limitations on the object shape, thickness, and transparency. Using single-mode optical fibers and a 658-nm laser source, the thickness measurement accuracy was assessed to be as high as 5 μm. In addition, refractive index of a transparent object with thickness smaller than the working distance of the focusing lenses can be measured. The thickness and refractive index of a planoconvex IOL were measured with a high accuracy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Noncontact method for sensing thickness and refractive index of intraocular lens implants using a self-calibrating dual-confocal laser caliper

Kim

James

Calogero³

et al. 2018

J. Biomed. Opt.

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Experimental and analytical quantification of light scattering from vacuoles in intraocular lenses

Spiezio

Walker

Calogero

et al. 2020

J Cataract Refract Surg

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Purpose: To develop an advanced test methodology for quantification of scattered light from intraocular lenses (IOLs) and to evaluate the correlation between IOL vacuole characteristics and measured scattered light. Setting: U.S. Food and Drug Administration, Optical Therapeutics and Medical Nanophotonics Laboratory, Silver Spring, Maryland, USA. Design: Experimental and analytical study. Methods: Twenty-four IOLs containing vacuoles were evaluated using a digital microscopy approach for identifying and characterizing the vacuoles present. A scanning light scattering profiler (SLSP) was used to evaluate and quantify the amount of scattered light from each IOL and from a 25th control IOL without any vacuoles. A variety of IOLs and vacuoles were also modeled in a Zemax simulation of the SLSP, and the simulated scattered light was modeled. Results: The scattered light as measured with SLSP was well correlated with vacuole characteristics, specifically density and size, as measured under the digital microscope for the 24 vacuole-containing IOLs. Additional correlations were found between vacuole sizes, orientations, and the angle at which light was scattered most severely. These correlations were also present in the Zemax model. Conclusions: Vacuole optical characteristics can be well correlated with measured scatter, demonstrating an ability to predict scattered light based solely on microscope evaluation. Furthermore, the quantitative amount of scatter predicted with Zemax simulations trended closely with the experimentally measured trends.

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Confocal laser method for quantitative evaluation of critical optical properties of toric intraocular lenses

Abstract: None of the authors has a financial or proprietary interest in any material or method mentioned.

Cited by 2 publications

References 14 publications

Noncontact method for sensing thickness and refractive index of intraocular lens implants using a self-calibrating dual-confocal laser caliper

Noncontact method for sensing thickness and refractive index of intraocular lens implants using a self-calibrating dual-confocal laser caliper

Experimental and analytical quantification of light scattering from vacuoles in intraocular lenses

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