Confocal microscopy: Imaging cervical precancerous lesions

Carlson, Kristen; Pavlova, Ina; Collier, Tom; Descour, Michael R.; Follen, Michele; Richards‐Kortum, Rebecca

doi:10.1016/j.ygyno.2005.07.049

Cited by 59 publications

(33 citation statements)

References 13 publications

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“…Furthermore, it may provide the patient with immediate diagnosis and treatment options at the same time. 13 Over the past 15 years not only fluorescence but also reflectance endomicroscopy [14][15][16][17][18] have been extensively investigated as a means for in vivo pathology and tissue differentiation. Reflectance microscopy relies on cellular and especially nuclear light backscattering.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence confocal endomicroscopy of the cervix: pilot study on the potential and limitations for clinical implementation

et al. 2016

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Abstract. Current diagnostic capabilities and limitations of fluorescence endomicroscopy in the cervix are assessed by qualitative and quantitative image analysis. Four cervical tissue types are investigated: normal columnar epithelium, normal and precancerous squamous epithelium, and stromal tissue. This study focuses on the perceived variability within and the subtle differences between the four tissue groups in the context of endomicroscopic in vivo pathology. Conclusions are drawn on the general ability to distinguish and diagnose tissue types, on the need for imaging depth control to enhance differentiation, and on the possible risks for diagnostic misinterpretations.

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Section: Introductionmentioning

confidence: 99%

Fluorescence confocal endomicroscopy of the cervix: pilot study on the potential and limitations for clinical implementation

et al. 2016

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“…Optical technologies such as fluorescence spectroscopy [40], polarised light scattering spectroscopy [41], optical coherence tomography [42,43] and confocal reflectance microscopy [44] have emerged in recent years as promising tools for diagnosis of cervical and other cancers. The potential of vibrational spectroscopy for cervical cancer diagnosis has also been recognised.…”

Section: Vibrational Spectroscopy For Cervical Cancer Pathology [34]mentioning

confidence: 99%

Vibrational Spectroscopy: Disease Diagnostics and Beyond

Byrne¹,

Ostrowska²,

Nawaz³

et al. 2013

Challenges and Advances in Computational Chemistry and Physics

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SummaryThis chapter outlines some developments in the applications of vibrational spectroscopy for disease diagnostics and demonstrates how the applications of the spectroscopic techniques can be extended to the analysis and evaluation of disease aetiology and the mechanisms of interaction with and the cellular and subcellular responses to, for example, chemotherapeutic agents and nanoparticles. The primary emphasis is on Raman spectroscopy, although some examples are based on infrared absorption spectroscopy. The studies presented are chosen to illustrate how a range of multivariate analytical techniques can be employed to maximize the potential benefits of the complex spectral information obtained from tissue or cells.

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“…Three years later, Carlson et al 75 demonstrated that in vivo confocal images of the cervix have the potential to give clinicians realtime structural information about possible cervical lesions. She showed that the nuclear-to-cytoplasm ratio from the differentiated superficial epithelium to the dense basal epithelium is increased in normal epithelium, but the images of dysplastic epithelium show little change from the upper layer to the basal layer of the epithelium.…”

Section: Confocal Microcolposcopymentioning

confidence: 99%

“…She showed that the nuclear-to-cytoplasm ratio from the differentiated superficial epithelium to the dense basal epithelium is increased in normal epithelium, but the images of dysplastic epithelium show little change from the upper layer to the basal layer of the epithelium. 75 Further research in this field is needed.…”

Section: Confocal Microcolposcopymentioning

confidence: 99%

Digital colposcopy: ready for use? An overview of literature

Louwers

Kocken

Harmsel

et al. 2008

BJOG

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The aims of this review were to summarise the various methods of digital colposcopy and to provide an overview of their efficacy. We conducted a literature search and focused on papers that described a technique for colposcopy, other than conventional colposcopy, and compared this with conventional colposcopy and/or histology and included digitalisation of the process. All papers have been classified in one of the following categories: digital imaging and telecolposcopy, spectroscopy, computerised colposcopy, optical coherence tomography and confocal microcolposcopy. Among the most promising developments is spectroscopy, allowing a more or less automated analysis and interpretation of the colposcopic image.

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Confocal microscopy: Imaging cervical precancerous lesions

Cited by 59 publications

References 13 publications

Fluorescence confocal endomicroscopy of the cervix: pilot study on the potential and limitations for clinical implementation

Fluorescence confocal endomicroscopy of the cervix: pilot study on the potential and limitations for clinical implementation

Vibrational Spectroscopy: Disease Diagnostics and Beyond

Digital colposcopy: ready for use? An overview of literature

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