We study the relation between the (generalized) conformal quantum mechanics of 0-branes and the two-dimensional dilaton gravity. The two-dimensional actions obtained from the supergravity effective actions for the (dilatonic) 0-branes through the compactification on a sphere are related to known two-dimensional dilaton gravity models. The SL(2, R) symmetry of the (generalized) conformal quantum mechanics is realized within such two-dimensional models. The two-dimensional dilatonic gravity model derived from the non-dilatonic 0-brane action is related to the Liouville theory and therefore is conformal, whereas the two-dimensional model derived from the dilatonic 0-brane action does not have the conformal symmetry.