Conformal Hydrogel Coatings on Catheters To Reduce Biofouling

Yong, You; Qiao, Mingyu; Chiu, Alan; Fuchs, Stephanie; Liu, Qingsheng; Pardo, Yehudah; Worobo, Randy W.; Liu, Zheng; Ma, Minglin

doi:10.1021/acs.langmuir.8b03074

Cited by 56 publications

(39 citation statements)

References 26 publications

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“…[180] Expanding on these techniques, both Yu et al and Yong et al developed methods to coat thin, conformal layers of tough hydrogels onto commercially available catheters. [175,181] Yong et al used a…”

Section: Tough Hydrogel Coatingsmentioning

confidence: 99%

“…shape-forming, gradient cross-linking, and swell-peeling) to coat a thin layer of tough, biocidal, and antifouling AAm−Agar−SBMA−HA gel that increased the lubricity and significantly reduced biofilm formation (90%) of the coated catheter compared to uncoated commercial catheters. [181] Yu et al formed multifunctional "hydrogel skins" on various substrates by employing benzophenone to robustly attach a variety of hydrogels (e.g., AAm, AA, DMAA, VP, and HEMA) that likewise led to low-friction, antifouling, and ionically conductive surfaces without compromising original mechanical properties and geometries ( Figure 13). [175] While there still remains no technique to bind materials (e.g.…”

Section: Tough Hydrogel Coatingsmentioning

confidence: 99%

Section: Corneal Tissue Engineeringmentioning

confidence: 99%

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Specialty Tough Hydrogels and Their Biomedical Applications

Fuchs

Shariati

2019

Adv Healthcare Materials

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164

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Hydrogels have long been explored as attractive materials for biomedical applications given their outstanding biocompatibility, high water content, and versatile fabrication platforms into materials with different physiochemical properties and geometries. Nonetheless, conventional hydrogels suffer from weak mechanical properties, restricting their use in persistent load-bearing applications often required of materials used in medical settings. Thus, the fabrication of mechanically robust hydrogels that can prolong the lifetime of clinically suitable materials under uncompromising in vivo conditions is of great interest. This review focuses on design considerations and strategies to construct such tough hydrogels. Several promising advances in the proposed use of specialty tough hydrogels for soft actuators, drug delivery vehicles, adhesives, coatings, and in tissue engineering settings are highlighted.

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Section: Tough Hydrogel Coatingsmentioning

confidence: 99%

Section: Tough Hydrogel Coatingsmentioning

confidence: 99%

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Specialty Tough Hydrogels and Their Biomedical Applications

Fuchs

Shariati

2019

Adv Healthcare Materials

Self Cite

164

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“…As another example, a conformal agar hydrogel coating was also modified with SB moieties to reduce biofouling on catheters. 202…”

Section: Sb-based Hydrogelsmentioning

confidence: 99%

Biomedical Uses of Sulfobetaine-Based Zwitterionic Materials

2020

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Protein fouling can render a biomedical device dysfunctional, and also serves to nucleate the foreign body reaction to an implanted material. Hydrophilic coatings have emerged as a commonly applied route to combat interface-mediated complications and promote device longevity and limited inflammatory response. While polyethylene glycol has received a majority of the attention in this regard, coatings based on zwitterionic moieties have been more recently explored. Sulfobetaines in particular constitute one such class of zwitterions explored for use in mitigating surface fouling, and have been shown to reduce protein adsorption, limit cellular adhesion, and promote increased functional lifetimes and limited inflammatory responses when applied to implanted materials and devices. Here, we present a focused review of the literature surrounding sulfobetaine, beginning with an understanding of its chemistry and the methods by which it is applied to the surface of a biomedical device in molecular and polymeric forms, and then advancing to the many early demonstrations of function in a variety of biomedical applications. Finally, we provide some insights into the benefits and challenges presented by its use, as well as some outlook on the future prospects for using this material to improve biomedical device practice by addressing interface-mediated complications.

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“…Furthermore, in the presence of urease-producing bacteria forming salt crystals on the surface, the catheter can be easily roughened to further increase friction, if not treated timely, causing massive obstruction (i.e., encrustation), antibiotic resistance of bacteria, and severe bacterial infection (Wang et al, 2015). To solve this problem, several antibacterial coating strategies have been developed including passive anti-adhesion to repel bacterial adhesion [e.g., poly(N-hydroxyethylacrylamide), and zwitterionic polymers], and active biocidal coating that can directly kill the bacteria on the surface (e.g., chitosan, N-halamine polymer, and other polymers with strong positive charges) combined with antibiotic agents to maximize the efficacy (e.g., silver; Dallas et al, 2011;Zhao et al, 2013;Ng et al, 2014;GhavamiNejad et al, 2016;Li et al, 2017;Yong et al, 2019). Along with the absence of surface functional groups in the elastomers used for urethral catheters, surface modification requires material-specific complexes and toxic chemical reactions producing coatings that lack appropriate mechanical stability for long-term use in a dynamic environment in vivo, hampering the translation into clinic (Voccia et al, 2006;Such et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Robust Low Friction Antibiotic Coating of Urethral Catheters Using a Catechol-Functionalized Polymeric Hydrogel Film

et al. 2019

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Indwelling urethral catheters are widely used in hospitalized patients. However, they are associated with bacterial infection and biofilm formation due to the suboptimal surface properties of the elastic materials used for the catheters. Although there are several antibacterial coating technologies to modify the surface properties of the catheter including hydrophilic polymeric coating, the risk of infection is still high given the absence of reactive functional groups on the surface of elastomers. In this study, we describe the use of catechol-functionalized hydrophilic polymers and explore strategies to create antibacterial hydrogel coatings. Three different types of catechol-functionalized polymers, chitosan, hyaluronic acid, and human serum albumin were synthesized and deposited using simple dip-coating method. All of the tested polymers could coat different types of elastomers widely used for urethral catheters independent of the surface properties while the thickness of the coating could be controlled by the number of depositions. The coating formed stable water-containing lubricant surface beneficial as a physical repellant of microbial attachment. In addition, the coating could be combined with additional antibacterial agents such as silver nanoparticles to maximize the antibacterial effect on the surface of urethral catheter materials.

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Conformal Hydrogel Coatings on Catheters To Reduce Biofouling

Cited by 56 publications

References 26 publications

Specialty Tough Hydrogels and Their Biomedical Applications

Specialty Tough Hydrogels and Their Biomedical Applications

Biomedical Uses of Sulfobetaine-Based Zwitterionic Materials

Robust Low Friction Antibiotic Coating of Urethral Catheters Using a Catechol-Functionalized Polymeric Hydrogel Film

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