We discuss the effect that small fluctuations of local anisotropy of pressure, and of energy density, may have on the occurrence of cracking in spherical compact objects, satisfying a polytropic equation of state. Two different kinds of polytropes are considered. For both, it is shown that departures from equilibrium may lead to the appearance of cracking, for a wide range of values of the parameters defining the polytrope. Prospective applications of the obtained results, to some astrophysical scenarios, are pointed out.