Conformation and distribution of groups on the surface of amphiphilic polyether-co-polyester dendrimers: Effect of molecular architecture

Dhanikula, Renu Singh; Hildgen, Patrice

doi:10.1016/j.jcis.2007.02.087

Cited by 7 publications

(4 citation statements)

References 44 publications

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“…The dendronized HPCs were also analyzed using tapping-mode atomic force microscopy (TM-AFM). This technique was successfully used earlier as a tool to visualize and study the size and shape of copolymers, dendrimers, , and hybrids thereof, such as dendronized polymers , and star-shaped molecules. , The nature of the substrate has been shown to play an important role in the adsorption process and the use of two substrates with opposite polarity has earlier been shown to result in different conformations of the samples subjected to analysis. , Alkyl functionalized dendrons/dendronized polymers adsorbed onto highly ordered pyrolytic graphite (HOPG) surfaces have shown to adopt epitaxial conformation of the alkyl chains, and the ordering was further improved by thermal annealing. However, more densely alkyl functionalized dendrons were less able to adsorb in an ordered pattern …”

Section: Resultsmentioning

confidence: 99%

“…The dendronized HPCs were also analyzed using tappingmode atomic force microscopy (TM-AFM). This technique was successfully used earlier as a tool to visualize and study the size and shape of copolymers, 39 dendrimers, 40,41 and hybrids thereof, such as dendronized polymers 5,6 and star-shaped molecules. 42,43 The nature of the substrate has been shown to play an important role in the adsorption process and the use of two substrates with opposite polarity has earlier been shown to result in different conformations of the samples subjected to analysis.…”

Section: Resultsmentioning

confidence: 99%

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Dendronized Hydroxypropyl Cellulose: Synthesis and Characterization of Biobased Nanoobjects

et al. 2007

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Dendronized polymers containing a cellulose backbone have been synthesized with the aim of producing complex molecules with versatile functionalization possibilites and high molecular weight from biobased starting materials. The dendronized polymers were built by attaching premade acetonide-protected 2,2-bis(methylol)propionic acid functional dendrons of generation one to three to a hydroxypropyl cellulose backbone. Deprotection or functionalization of the end groups of the first generation dendronized polymer to hydroxyl groups and long alkyl chains was performed, respectively. The chemical structures of the dendronized polymers were confirmed through analysis using (1)H NMR and FT-IR spectroscopies. From SEC analysis, the dendronized polymers were found to have an increasing polystyrene-equivalent molecular weight up to the second generation ( M n = 50 kg mol (-1)), whereas the polystyrene-equivalent molecular weight for the third generation was lower than for the second, although the same grafting density was obtained from (1)H NMR spectroscopy for the second and third generations. Tapping-mode atomic force microscopy was used to characterize the properties of the dendronized polymers in the dry state, exploring both the effect of the polar substrate mica and the less polar substrate highly oriented pyrolytic graphite (HOPG). It was found that the molecules were in the size range of tens of nanometers and that they were apt to undertake a more elongated conformation on the HOPG surfaces when long alkyl chains were attached as the dendron end-groups.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Dendronized Hydroxypropyl Cellulose: Synthesis and Characterization of Biobased Nanoobjects

et al. 2007

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“…These processes may be applicable to cationic dendrimers. Therefore, dendrimer cell safety assessment is in urgent need of such approaches, and particularly in relation to partially or fully biodegradable species such as polyether, ,, polyether- co -polyester, − phosphate, melamine, ,,− and peptide dendrimers. − Indeed, unraveling the mechanism of biodegradable dendrimer-mediated cytotoxic responses is central for careful design and engineering of dendritic macromers for drug delivery and controlled modulation of biological processes.…”

Section: Dendrimer Safety and Toxicity Challengesmentioning

confidence: 99%

Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges

et al. 2015

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Dendrimers are three-dimensional macromolecular structures originating from a central core molecule and surrounded by successive addition of branching layers (generation). These structures exhibit a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, as well as multivalency. Collectively, these physicochemical characteristics together with advancements in design of biodegradable backbones have conferred many applications to dendrimers in formulation science and nanopharmaceutical developments. These have included the use of dendrimers as pro-drugs and vehicles for solubilization, encapsulation, complexation, delivery, and site-specific targeting of small-molecule drugs, biopharmaceuticals, and contrast agents. We briefly review these advances, paying particular attention to attributes that make dendrimers versatile for drug formulation as well as challenging issues surrounding the future development of dendrimer-based medicines.

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“…[177][178] 2 mg mL À1 . 105 Polyether-copolyester dendrimer with gallic acid repeated units and methacrylate surface showed excellent biocompatibility on U87 MG and U343 MGa cells 189 and were able to penetrate across the blood-brain barrier for the treatment of brain tumours (apparent permeation coefficient ranges from 20 Â 10 À6 to 39 Â 10 À6 cm s À1 , depending on the dendrimer generation) [190][191][192] (Fig. 28).…”

Section: Construction Of New Biocompatible Dendrimersmentioning

confidence: 99%

Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives

et al. 2011

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In the past decade, nanomedicine with its promise of improved therapy and diagnostics has revolutionized conventional health care and medical technology. Dendrimers and dendrimer-based therapeutics are outstanding candidates in this exciting field as more and more biological systems have benefited from these starburst molecules. Anticancer agents can be either encapsulated in or conjugated to dendrimer and be delivered to the tumour via enhanced permeability and retention (EPR) effect of the nanoparticle and/or with the help of a targeting moiety such as antibody, peptides, vitamins, and hormones. Imaging agents including MRI contrast agents, radionuclide probes, computed tomography contrast agents, and fluorescent dyes are combined with the multifunctional nanomedicine for targeted therapy with simultaneous cancer diagnosis. However, an important question reported with dendrimer-based therapeutics as well as other nanomedicines to date is the long-term viability and biocompatibility of the nanotherapeutics. This critical review focuses on the design of biocompatible dendrimers for cancer diagnosis and therapy. The biocompatibility aspects of dendrimers such as nanotoxicity, long-term circulation, and degradation are discussed. The construction of novel dendrimers with biocompatible components, and the surface modification of commercially available dendrimers by PEGylation, acetylation, glycosylation, and amino acid functionalization have been proposed as available strategies to solve the safety problem of dendrimer-based nanotherapeutics. Also, exciting opportunities and challenges on the development of dendrimer-based nanoplatforms for targeted cancer diagnosis and therapy are reviewed (404 references).

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Conformation and distribution of groups on the surface of amphiphilic polyether-co-polyester dendrimers: Effect of molecular architecture

Cited by 7 publications

References 44 publications

Dendronized Hydroxypropyl Cellulose: Synthesis and Characterization of Biobased Nanoobjects

Dendronized Hydroxypropyl Cellulose: Synthesis and Characterization of Biobased Nanoobjects

Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges

Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives

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