“…The average age difference between FH and non-FH sibs was 0.56 years and the male:female ratios were 1:1.6 and 1:1.2 respectively, Furthermore, it is well established that age and sex have no effect on Lp(a) in adults, with the possible exception of the postmenopausal state in women which has been reported to be associated with elevated Lp(a) in some but not all studies. 34,35 Only two postmenopausal women were present within the sib pairs and both belonged to the non-FH group. Thus if there had been any effect it would have been to reduce rather than increase the difference in Lp(a) levels between FH and non-FH sibs.…”