Conformations and Solution Properties of Star-Branched Polyelectrolytes

Borisov, Oleg V.; Zhulina, Ekaterina B.; Leermakers, F.A.M.; Ballauff, Matthias; Müller, Axel H. E.

doi:10.1007/12_2010_104

Cited by 47 publications

(87 citation statements)

References 148 publications

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“…The properties of these micelles are reviewed in detail elsewhere [93]. In most cases, the core domain formed upon association of strongly hydrophobic blocks is found in a kinetically "frozen" state, e.g., poly(styrene) (PS) associating blocks are in a glassy state.…”

Section: Ipecs Based On Micelles Of Ionic Amphiphilic Diblock Copolymersmentioning

confidence: 99%

Interpolyelectrolyte Complexes Based on Polyionic Species of Branched Topology

Pergushov

Borisov

Зезин

et al. 2010

Self Organized Nanostructures of Amphiphilic Block Copolymers I

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Section: Ipecs Based On Micelles Of Ionic Amphiphilic Diblock Copolymersmentioning

confidence: 99%

Interpolyelectrolyte Complexes Based on Polyionic Species of Branched Topology

Pergushov

Borisov

Зезин

et al. 2010

Self Organized Nanostructures of Amphiphilic Block Copolymers I

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“…This phenomenological value is close to the theoretical exponent ¼ predicted for the radius of a star--like copolymer consisting of p ideal (Gaussian) non--interacting branches linked together (an assumption that is obviously not the case with the ELP chains). 51 However, in Θ--solvent, such uni-molecular star--like micelle follows a scaling law ~! /!…”

Section: Eq 11mentioning

confidence: 99%

Structural Evolution of a Stimulus-Responsive Diblock Polypeptide Micelle by Temperature Tunable Compaction of its Core

et al. 2015

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International audienceWith a perfectly defined primary structure, both in terms of monomer sequence and chain length, recombinant polypeptides obtained by protein engineering techniques allow the investigation of structure property relationships at a level of detail that is difficult to achieve with traditional synthetic polymers because of the precision with which their sequence can be defined. In the present work, we have studied the behavior and temperature-triggered self-assembly of a series of diblock recombinant elastin-like polypeptides (ELPs) with the goal of elucidating the mechanism of their self-assembly into micelles. Aqueous solutions of diblock ELPs were studied below and above their critical micellar temperature (CMT) by multiangle light scattering and small-angle neutron scattering techniques. Below the CMT, the radius of gyration of soluble ELP chains follows a power law as a function of molecular weight with an exponent value close to 0.5 that is characteristic of Gaussian coil conformations. As the temperature reaches the CMT, attractive interactions between the more hydrophobic block of diblock ELP chains leads to the self-assembly of monodisperse spherical micelles at thermodynamic equilibrium. Above the CMT, micelles expel water molecules from their core whose densification is evidenced by the monotonic increase in the light and neutron scattering intensities as a function of temperature. The behaviors of these different diblock ELPs in solution and as self-assembled nanoparticles above the CMT following universal experimental scaling laws make them analogous to synthetic amphiphilic diblock copolymers (star-like vs crew-cut micelle models). These studies also shed light on the important role of water in the thermal behavior of these thermally responsive self-assembling diblock polypeptides and suggest a new design parameter thermally triggered desolvation and densification of the core of micelles that can be fine-tuned at the sequence level to control the density of self-assembled polymer nanoparticles

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“…Then we shall present a survey on recent work done on spherical polyelectrolyte brushes which are characterized by a strong confinement of the counterions. 93,104 Up to this point the discussion is restricted to full equilibrium and an entirely thermodynamic treatment. Recent theoretical work, however, has suggested that the kinetics of the binding of proteins to gels can be understood in terms of a dynamic density functional theory.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Proteins with Polyelectrolytes: Comparison of Theory to Experiment

et al. 2018

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We discuss recent investigations of the interaction of polyelectrolytes with proteins. In particular, we review our recent studies on the interaction of simple proteins such as human serum albumin (HSA) and lysozyme with linear polyelectrolytes, charged dendrimers, charged networks, and polyelectrolyte brushes. In all cases discussed here, we combined experimental work with molecular dynamics (MD) simulations and mean-field theories. In particular, isothermal titration calorimetry (ITC) has been employed to obtain the respective binding constants K and the Gibbs free energy of binding. MD simulations with explicit counterions but implicit water demonstrate that counterion release is the main driving force for the binding of proteins to strongly charged polyelectrolytes: patches of positive charges located on the surface of the protein become multivalent counterions of the polyelectrolyte, thereby releasing a number of counterions condensed on the polyelectrolyte. The binding Gibbs free energy due to counterion release is predicted to scale with the logarithm of the salt concentration in the system, which is verified by both simulations and experiment. In several cases, namely, for the interaction of proteins with linear polyelectrolytes and highly charged hydrophilic dendrimers, the binding constant could be calculated from simulations to very good approximation. This finding demonstrated that in these cases explicit hydration effects do not contribute to the Gibbs free energy of binding. The Gibbs free energy can also be used to predict the kinetics of protein uptake by microgels for a given system by applying dynamic density functional theory. The entire discussion demonstrates that the direct comparison of theory with experiments can lead to a full understanding of the interaction of proteins with charged polymers. Possible implications for applications, such as drug design, are discussed.

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Conformations and Solution Properties of Star-Branched Polyelectrolytes

Cited by 47 publications

References 148 publications

Interpolyelectrolyte Complexes Based on Polyionic Species of Branched Topology

Interpolyelectrolyte Complexes Based on Polyionic Species of Branched Topology

Structural Evolution of a Stimulus-Responsive Diblock Polypeptide Micelle by Temperature Tunable Compaction of its Core

Interaction of Proteins with Polyelectrolytes: Comparison of Theory to Experiment

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