2024
DOI: 10.1021/acschembio.4c00152
|View full text |Cite
|
Sign up to set email alerts
|

Confounding Factors in Targeted Degradation of Short-Lived Proteins

Vesna Vetma,
Laura Casares Perez,
Ján Eliaš
et al.

Abstract: Targeted protein degradation has recently emerged as a novel option in drug discovery. Natural protein half-life is expected to affect the efficacy of degrading agents, but to what extent it influences target protein degradation has not been systematically explored. Using simple mathematical modeling of protein degradation, we find that the natural half-life of a target protein has a dramatic effect on the level of protein degradation induced by a degrader agent which can pose significant hurdles to screening … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2025
2025

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 6 publications
references
References 36 publications
0
0
0
Order By: Relevance