Congenital abnormalities in children of 43 pregnant women who attempted suicide with large doses of nitrazepam

Gidai, János; Ács, Nándor; Bánhidy, Ferenc; Czeizel, Andr̀ew E.

doi:10.1002/pds.1885

Cited by 21 publications

(18 citation statements)

References 24 publications

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“…73 Moreover, a linked Vital Statistics-Patient Discharge State of California database confirmed that suicide attempts during pregnancy might be associated with significantly higher rates of maternal and perinatal morbidity, and in some cases, perinatal mortality. 30 In fact, such women showed an increase in the risk of premature labor, caesarean delivery, and need for blood transfusion.…”

Section: Resultsmentioning

confidence: 98%

Suicidal mothers

Gentile¹

2011

J Inj Violence Res

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Abstract:Background:Epidemiological research has demonstrated that suicidal ideation is a relatively frequent complication of pregnancy in both developed and developing countries. Hence, the aims of this study are: to assess whether or not pregnancy may be considered a period highly susceptible to suicidal acts; to recognize potential contributing factors to suicidal behaviors; to describe the repercussions of suicide attempts on maternal, fetal, and neonatal outcome; to identify a typical profile of women at high risk of suicide during pregnancy.Methods:Medical literature information published in any language since 1950 was identified using MEDLINE/PubMed, Scopus, and Google Scholar databases. Search terms were: "pregnancy", (antenatal) "depression", "suicide". Searches were last updated on 28 September 2010. Forty-six articles assessing the suicidal risk during pregnancy and obstetrical outcome of pregnancies complicated by suicide attempts were analyzed, without methodological limitations.Results:Worldwide, frequency of suicidal attempts and the rate of death by suicidal acts are low. Although this clinical event is rare, the consequences of a suicidal attempt are medically and psychologically devastating for the mother-infant pair. We also found that common behaviors exist in women at high risk for suicide during pregnancy. Review data indeed suggest that a characteristic profile can prenatally identify those at highest risk for gestational suicide attempts.Conclusions:Social and health organizations should make all possible efforts to identify women at high suicidal risk, in order to establish specific programs to prevent this tragic event. The available data informs health policy makers with a typical profile to screen women at high risk of suicide during pregnancy. Those women who have a current or past history of psychiatric disorders, are young, unmarried, unemployed, have incurred an unplanned pregnancy (eventually terminated with an induced abortion), are addicted to illicit drugs and/or alcohol, lack effective psychosocial support, have suffered from episodes of sexual or physical violence are particularly vulnerable.

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Section: Resultsmentioning

confidence: 98%

Suicidal mothers

Gentile¹

2011

J Inj Violence Res

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“…The majority of studies that have assessed the impact of suicidal ideation during pregnancy on fetal development have done so in the context of self-poisoning. A series of 15 articles were published from the Budapest Monitoring System of Self-Poisoning Pregnant Women that evaluated the potential effects of large doses of drugs on fetal development among pregnant women who attempted suicide (Czeizel et al, 1997, Czeizel et al, 1999, Timmermann et al, 2009, Gidai et al, 2008c, Gidai et al, 2008a, Gidai et al, 2008d, Gidai et al, 2008b, Gidai et al, 2010, Petik et al, 2008a, Petik et al, 2008b, Petik et al, 2012, Timmermann et al, 2008b, Timmermann et al, 2008a, Timmermann et al, 2008c). With regards to congenital anomalies, the primary outcomes of these studies, no statistically significant associations were reported with self-poisoning (Czeizel et al, 1997, Czeizel et al, 1999, Timmermann et al, 2009, Gidai et al, 2008c, Gidai et al, 2008a, Gidai et al, 2008d, Gidai et al, 2008b, Gidai et al, 2010, Petik et al, 2008a, Petik et al, 2008b, Petik et al, 2012, Timmermann et al, 2008b, Timmermann et al, 2008a, Timmermann et al, 2008c).…”

Section: Resultsmentioning

confidence: 99%

Suicidal ideation in pregnancy: an epidemiologic review

Gelaye

Kajeepeta

Williams

2016

Arch Womens Ment Health

139

125

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Objective Suicidal behaviors are the leading causes of injury and death worldwide, and are leading causes of maternal deaths in some countries. One of the strongest risk factors, suicidal ideation, is considered a harbinger and distal predictor of later suicide attempt and completion, and also presents an opportunity for interventions prior to physical self-harm. The purpose of this systematic epidemiologic review is to synthesize available research on antepartum suicidal ideation. Data sources Original publications were identified through searches of the electronic databases using the search terms pregnancy, pregnant women, suicidal ideation, and pregnan* and suicid* as root searches. We also reviewed references of published articles. Study Selection We identified a total of 2,626 articles through the electronic database search. After irrelevant and redundant articles were excluded 57 articles were selected. The selected articles were original articles that focused on pregnancy and suicidal ideation. Results Of the 57 included articles, 20 reported prevalence, 26 reported risk factors, 21 reported consequences of antepartum suicidal ideation, and 5 reported on screening measures. Available evidence indicates that pregnant women are more likely than the general population to endorse suicidal ideation. Additionally, a number of risk factors for antepartum suicidal ideation were identified including intimate partner violence, <12 years education, and major depressive disorder. Conclusion There is a need for enhanced screening for antepartum suicidal ideation. The few screening instruments that exist are limited as they were primarily developed to measure antepartum and postpartum depression. Given a substantial proportion of women with suicidal ideation do not meet clinical thresholds of depression and given the stress–diathesis model that shows susceptibility to suicidal behavior independent of depressive disorders, innovative approaches to improve screening and detection of antepartum suicidal ideation are urgently needed.

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“…Women with antenatal depression are less likely to participate in recommended prenatal care practices, and are at increased risk of engaging in risky health behaviours, such as smoking and substance use in pregnancy [4], thereby increasing risk of adverse obstetrical outcomes, including preterm birth and low birth weight [6–8], and long-term adverse health effects on the child. In addition, fetal exposure to maternal suicide attempts is associated with mental retardation and serious congenital abnormalities [9–11]. Research shows that a significant percentage of women who experience perinatal depression and anxiety will develop recurrent long-term mood disorders (unipolar and bipolar depression) [12,13].…”

Section: Long-term Psychiatric Complications Of Perinatal Mental Illnessmentioning

confidence: 99%

The long-term psychiatric and medical prognosis of perinatal mental illness

Meltzer‐Brody

Stuebe

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

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The perinatal period provides an important window into a woman’s long-term health. Perinatal mental illness is a common condition conferring potential serious long-term psychiatric and medical consequences for the mother and family. It is known that childbirth acts as a powerful trigger for depressive episodes in some women, and that women with histories of a mood disorder are particularly vulnerable. Some evidence links perinatal mental illness with obstetrical complications and reduced lactation initiation and duration. Therefore, perinatal mental illness may be a marker for long-term risk, and may contribute directly to subsequent cardiometabolic disease through both neuroendocrine mechanisms and the effects of mental illness on health behaviours. In clinical practice, these associations underscore the importance of screening and treating women with perinatal mental illness to ensure best possible long-term outcomes. Early screening and treatment may both mitigate the primary disease process and reduce the risk of comorbid medical conditions.

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Congenital abnormalities in children of 43 pregnant women who attempted suicide with large doses of nitrazepam

Cited by 21 publications

References 24 publications

Suicidal mothers

Suicidal mothers

Suicidal ideation in pregnancy: an epidemiologic review

The long-term psychiatric and medical prognosis of perinatal mental illness

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