Congenital Abnormalities of the Posterior Fossa

Bosemani, Thangamadhan; Orman, Güneş; Boltshauser, Eugen; Tekes, Aylin; Huisman, Thierry A. G. M.; Poretti, Andrea

doi:10.1148/rg.351140038

Cited by 165 publications

(122 citation statements)

References 83 publications

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“…The diagnostic range of congenital anomalies in the posterior fossa reflects their anatomical predominance and the fact that the classification and the terms “DWM” and “DWV” have been controversial [62]. Advances in genetics and imaging have provided a better understanding of the embryologic origins of these abnormalities [63].…”

Section: Discussionmentioning

confidence: 99%

Dandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review

et al. 2018

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Introduction: Dandy-Walker malformation is a rare congenital malformation involving cystic dilatation of the fourth ventricle, enlarged posterior fossa, complete or partial agenesis of the cerebellar vermis, elevated tentorium cerebelli, and hydrocephalus. Previous research highlighted a possible role for the cerebellum in schizophrenia as well as the contribution of underlying brain malformations to treatment resistance. Here, we present a case of a Dandy-Walker malformation-like condition revealed by a refractory schizophrenia in a 24-year-old male patient. We also conduct a literature review of all previously published case reports or case series of co-occurring posterior fossa abnormalities and schizophrenia or psychosis using a PubMed search query to better understand the potential link between these two disorders. Case Presentation: A 9-month hospital stay was needed to address the treatment-resistant psychotic symptoms, and the patient continued to experience moderate symptoms despite the prescription of various antipsychotic and antidepressant medications. After an irregular initial medical follow-up, the patient is currently treated with 350 mg daily clozapine and 20 mg daily prazepam and still exhibits moderate anxiety without delirious thoughts, however allowing him to re-enroll at the university. Regarding the literature, 24 cases published between 1996 and 2017 were identified, reviewed and compared to the present case report. Discussion: This case report and literature review further illuminates the pathophysiology of psychotic disorders including the potential role of the cerebellum, reinforces the importance of a multidisciplinary approach for the neurological and psychiatric management of patients with schizophrenia, and highlights optimal pharmacological management strategies for treatment-resistant schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Dandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review

et al. 2018

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“…Macrocephaly is the most common manifestation and in 80% of cases the diagnosis is made by the first year of life. 12 Our case was symptomatic since 7 years of age most likely due to cardiac abnormality (PDA) and neurological symptoms (headache and convulsion) developed at 11 years of age. There are few case reports of DWM where patients were asymptomatic until death (died due to breast cancer at 52 years of age) or upto the age of 59 years when patient presented with headache and computed tomography and MRI of those patients revealed DWM 13 .…”

Section: Discussionmentioning

confidence: 82%

Dandy –Walker Malformation with Patent Ductus Arteriosus– A Case Report

Begum

Rahman

2018

J. Bangladesh Coll. Phys.

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Dandy-Walker malformation (DWM) is a group of congenital human brain malformation with specific characteristics. It may be associated with a number of other organ malformation including heart, eye, and thyroid glands. In our case, DWM was associated with heart malformation in the form of patent ductus arteriosus (PDA) and was complicated by atrial fibrillation. The case was established by computed tomography of brain, echocardiography and electrocardiography. The patient was asymptomatic until 7 years of age.(J Bangladesh Coll Phys Surg 2018; 36: 128-131)

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“…The presence of cortical malformations can help differentiate Zika virus related congenital infection from toxoplasmosis, as malformations of cortical development are uncommon in the latter. 20 An enlarged cisterna magna (≥10 mm on midsagittal images) 25 was a common finding, even in children with no signs of cerebellar hypoplasia. A similar finding was reported in the fetus of a mother who had symptoms compatible with Zika virus infection.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study

2016

BMJ

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Congenital Abnormalities of the Posterior Fossa

Cited by 165 publications

References 83 publications

Dandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review

Dandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review

Dandy –Walker Malformation with Patent Ductus Arteriosus– A Case Report

Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study

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