Congenital adrenal hyperplasia at the Lagos University Teaching Hospital: A 10-year review

Oyenusi, Elizabeth Eberechi; Oduwole, Abiola; Okorie, Obasi Onwuka; Adekoya, AO; Nwaogu, Nwaoma Tochukwu; Asafo-Agyei, Serwah Bonsu

doi:10.4103/2468-6859.192291

Cited by 4 publications

(7 citation statements)

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“…The hydrocortisone suppresses the production of adrenal androgens and stimulates the release of gonadotrophins if hypothalamic maturation is already present. [20,21] All our patients with CPP are receiving treatment with a GnRH analogue. In SA, considerable limitations exist in optimally managing this condition.…”

Section: Discussionmentioning

confidence: 99%

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency in South Africa

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency in South Africa

et al. 2018

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“…15 Female sex predominance was also seen in the Assiut study. 16 However, equal sex distribution was seen in the Nigerian study by Oyenusi et al 5 The age at presentation of most patients in this study ranged between 1 day and 10 years, with a mean age of around 2 years. In comparison with the study done at Assiut University Children's Hospital by Bakhit et al, 16 according to the age at diagnosis, the cases were in the age range from 1 month to 10 years, with a mean age at diagnosis of 15 months.…”

Section: Discussionmentioning

confidence: 47%

“…17 Consanguinity accounts for 67.2% of patients with CAH in the study population compared with a study with no history of consanguineous marriage in Nigeria. 5 Also, the patients in Asian countries where parental consanguinity with CAH ranged from 52.3 to 82%. 16 18 19 20 CAH is the most common adrenal disorder in childhood and was documented to be the most common cause of ambiguous genitalia in newborns.…”

Section: Discussionmentioning

confidence: 99%

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Experience with Congenital Adrenal Hyperplasia in Tripoli Children's Hospital, Libya

Abulgassem

BenRajab

2022

Journal of Diabetes and Endocrine Practice

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Congenital adrenal hyperplasia (CAH) denotes a group of autosomal recessive disorders. Its clinical spectrum varies from classical CAH (CCAH) to nonclassic CAH. It may be a simple virilizing form or salt-wasting type. The study described the clinical presentation, treatment modalities, and sequelae of CAH, including its effect on patient growth during long-term follow-up. A case series study was conducted on patients with CAH who attended and followed up in the Endocrine Clinic in Tripoli Children's Hospital from January 1, 2000 to December 31, 2018. The presentation and the last visit captured demographic and clinical features at the time of diagnosis, types of CAH (classical vs. nonclassical), investigations, treatment details, and height. All patients underwent biochemical testing and hormonal assay, including adrenocorticotropin hormone (ACTH), 17-hydroxyprogesterone (17-OHP), and plasma renin activity (PRA) levels before and after treatment. Fifty-eight patients were included; 38 (65.5.2%) were female, age at presentation in 94.8% ranged between 1 day and 10 years, with a mean age of 2.3 ± 1.1 years. Ambiguous genitalia was the presenting feature in 55.2 and 84% of total and female patients, respectively. Salt wasting was present in 37.9%. Of 32 female patients with ambiguous genitalia, only 11 (34.4%) out of them and 19% of all patients had a surgical correction. The mean and standard deviation of height at diagnosis was 78.327 + 31.070, and the last visit after treatment was 108.345 + 31.781. The relation between the date of birth and height throughout follow-up for those at last visit with age ranges from 13 to 18 years old, their mean and standard deviation of height was 135.650 + 29.286, and for patients who were less than13 years at last visit, the mean and standard deviation of height was 101.079 + 32.121; p-value = 0.003. The Z-scores were calculated and showed that about eight patients were positively above the average mean of the population. Biochemical disturbances were improved after treatment, including sodium, potassium, and glucose in CCAH type; p-value < 0.001. Hormonal findings included levels of ACTH, 17-OHP, and PRA; all levels were reduced with treatment; p-value < 0.001. In this single-center series, most of our patients with biochemical and hormonal abnormalities were normalized with hormonal replacement and limited surgical correction of females with ambiguous genitalia.

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“…In countries where routine newborn screening for congenital adrenal hyperplasia is not practiced, the availability of references for clitoral sizes and ano-genital distances may be helpful in assessing virilised genetic females and investigating them further. In a recent Nigerian publication, four females out of 24 children (16.7%) with different types of CAH presented in the neonatal period with ambiguous external genitalia in a 10-year review of CAH [11].…”

Section: Introductionmentioning

confidence: 99%

Clitoral sizes and anogenital distances in term newborns in Nigeria

Adekoya

Fetuga

Jarrett

et al. 2019

Int J Pediatr Endocrinol

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BackgroundPrevious studies suggest significant ethnic and racial differences in clitoral sizes and anogenital distances in the newborn. This study aimed to document normative data on clitoral sizes and anogenital distances of apparently normal term female infants in Sagamu.MethodsThe study was a multi-center, cross-sectional descriptive research carried out among 317 female term infants within the first 72 h of life. Interviewer-based questionnaire was applied to obtain sociodemographic data, pregnancy and birth history. A sliding digital caliper was used for measurement. Data analysis was with SPSS version 20.0.ResultsThe mean clitoral length was 6.7 ± 1.6 mm while the mean clitoral width was 5.6 ± 0.8 mm. The mean fourchette-clitoris distance, anus-clitoris distance and anus-fourchette distance were 21.9 ± 2.1 mm, 35.5 ± 2.5 mm and 17.0 ± 2.6 mm respectively. The anus-clitoris and anus-fourchette distances significantly correlated with the anthropometric parameters while the clitoral measurements did not.ConclusionThe mean values recorded in this study were higher than observed in most previous studies. This simple, affordable and non-invasive evaluation could aid early diagnosis and treatment of female infants with potentially harmful conditions such as congenital adrenal hyperplasia.

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Congenital adrenal hyperplasia at the Lagos University Teaching Hospital: A 10-year review

Cited by 4 publications

References 0 publications

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency in South Africa

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency in South Africa

Experience with Congenital Adrenal Hyperplasia in Tripoli Children's Hospital, Libya

Clitoral sizes and anogenital distances in term newborns in Nigeria

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