Congenital alkalosis with diarrhea

Darrow, Daniel C.

doi:10.1016/s0022-3476(45)80079-3

Cited by 169 publications

(63 citation statements)

References 27 publications

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“…These findings, namely, displacement of intracellular potassium on administration of' sodium citrate,3 strongly support the excellent studies of Darrow (8,(10)(11)(12)(13) that the intracellular sodium plays a role in the defense of the normal extracellular pH.…”

Section: Displacement Of Intracellular Potassium By Sodiummentioning

confidence: 52%

Some Effects of Variation in Sodium Intake and of Different Sodium Salts in Normal Subjects 1

Leaf

Couter²,

Newburgh³

1949

J. Clin. Invest.

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In a separate paper ( 1 ) we have described effects resulting from variation of sodium intake in normal subjects, which we attribute to changes in adrenal cortical activity. It is the purpose of this paper to describe some additional effects of considerable physiological interest that were observed in the course of that study. METHODSThree normal young adults were maintained throughout the study on a constant diet adequate in calories and protein with a very low sodium (about 9 mEq.) and chloride (about 25 mEq.) content. At definite periods 480 mEq. of sodium were administered orally daily either as sodium chloride or as sodium citrate. The analytical methods and diet are described in detail in the previous report (1). RESULTSThe complete data of this study were presented in a separate paper (1). Only data pertinent to the present discussions will be presented here. Table I shows the weights of our three normal subjects for the three days before, during and following sodium administration. It is evident that with sodium chloride administration a much more marked gain of weight occurred than with sodium citrate. Each subject was on a maintenance caloric intake so that practically all weight changes occurring over such short periods as these are due to change in body fluid content. Table II shows the changes in urinary sodium, chloride and potassium excretion that occurred before, during and following each period of sodium administration. No significant changes in fecal sodium, chloride, and potassium were noted and these are not recorded here. It is seen that with administration of sodium chloride there is in each case a parallel increase in both urinary sodium and chloride as would be expected. Following the 1 This study was aided by a grant from the United States Public Health Service. sodium citrate administration a similar increase in sodium excretion is noted; however, chloride excretion remains unchanged, or if anything, slightly decreases. Table II shows further that with the sodium chloride administration no significant increase in potassium excretion occurred except in the case of M. L., whose urine potassium content rose from about 40 mEq. in 24 hours to 88 mEq. the first day of sodium chloride administration. In subjects W. C. and E. W. a significant decrease in potassium excretion occurred after cessation of sodium chloride administration. On the first day of sodium citrate administration, a very definite increase in potassium excretion took place in all subjects. This was followed, after omission of sodium citrate, by a decrease to unusually low levels of potassium excretion. Table III shows the data we have collected re-

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Section: Displacement Of Intracellular Potassium By Sodiummentioning

confidence: 52%

Some Effects of Variation in Sodium Intake and of Different Sodium Salts in Normal Subjects 1

Leaf

Couter²,

Newburgh³

1949

J. Clin. Invest.

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“…Completing the analogy, the author has shown in unpublished work that rats receiving desoxycorticosterone acetate or cortical extract, while on a diet low in potassium, develop high serum pH and high bicarbonate as well as low chloride and potassium. The association of alkalosis with changes in the composition of intracellular fluids was also shown in a baby who lost more chloride than sodium in diarrheal stools (9).…”

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confidence: 80%

Changes in Muscle Composition in Alkalosis 1

Darrow

1946

J. Clin. Invest.

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“…Congenital Chloridorrhea. In this disorder, high-volume watery diarrhea begins at birth (38,39). The disorder is caused by a loss of function mutation in the downregulated in adenoma (DRA or CLD) gene, leading to an absence of any functioning gut Cl Ϫ /HCO 3 Ϫ exchange (40,41).…”

Section: Diarrheamentioning

confidence: 99%

Acid-Base Disturbances in Gastrointestinal Disease

Gennari¹,

Weise²

2008

Clinical Journal of the American Society of Nephrology

141

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Disruption of normal gastrointestinal function as a result of infection, hereditary or acquired diseases, or complications of surgical procedures uncovers its important role in acid-base homeostasis. Metabolic acidosis or alkalosis may occur, depending on the nature and volume of the unregulated losses that occur. Investigation into the specific pathophysiology of gastrointestinal disorders has provided important new insights into the normal physiology of ion transport along the gut and has also provided new avenues for treatment. This review provides a brief overview of normal ion transport along the gut and then discusses the pathophysiology and treatment of the metabolic acid-base disorders that occur when normal gut function is disrupted.

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Congenital alkalosis with diarrhea

Cited by 169 publications

References 27 publications

Some Effects of Variation in Sodium Intake and of Different Sodium Salts in Normal Subjects 1

Some Effects of Variation in Sodium Intake and of Different Sodium Salts in Normal Subjects 1

Changes in Muscle Composition in Alkalosis 1

Acid-Base Disturbances in Gastrointestinal Disease

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