Congenital anaplastic astrocytoma with favorable prognosis

Roosen, N.; Deckert, Martina; Nicola, N.; Wechsler, W.; Schober, R.; Voss, Hubertus von; Mayer, Philipp; Werner, Cassidy

doi:10.3171/jns.1988.69.4.0604

Cited by 26 publications

(13 citation statements)

References 42 publications

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“…Our review of findings published in the Surveillance, Epidemiology, and End Results database 8 on children younger than 1 year with high-grade glioma or diffuse pontine glioma revealed that these patients may have a better outcome than their older counterparts. Such limited data and incidental case reports of spontaneous regression in a neonatal diffuse pontine glioma 29 or cure of neonatal high-grade glioma via surgery only 30 provide evidence that, like leukemia 2,3 and neuroblastoma, 4 brain tumors that arise during early infancy may have a different biological behavior than in older infants.…”

Section: Discussionmentioning

confidence: 99%

Characterization, Treatment, and Outcome of Intracranial Neoplasms in the First 120 Days of Life

et al. 2011

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Little is known about brain tumors in early infancy. We reviewed the records of 27 patients (12 boys and 15 girls) diagnosed within 120 days of birth. The median age was 66 days (range, 0–110 days) at diagnosis. All patients underwent surgery; 18 received adjuvant chemotherapy, and 3 received adjuvant chemotherapy and radiation therapy. The median follow-up was 2.1 years (range, 0.2–21.6 years). At last encounter, 15 patients were alive, and 11 had no evidence of disease. Ten patients died of progressive disease, and 2 died of treatment-related complications. All survivors experienced late effects, including endocrine, neurologic, and cognitive deficits. Of the 13 patients who completed neurocognitive assessments, 7 had an IQ score less than 70. Children in whom brain tumors arise during early infancy can be cured with conventional therapy; however, contemporary approaches can adversely affect long-term function, and families need to be aware when making therapeutic decisions.

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Section: Discussionmentioning

confidence: 99%

Characterization, Treatment, and Outcome of Intracranial Neoplasms in the First 120 Days of Life

et al. 2011

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“…All ten anaplastic astrocytomas were located in the cerebral hemispheres [14, 18, 19, 27, 57, 69, 80, 94] (Table 5). Microscopically, they show cytoplasmic and nuclear pleomorphism, hypercellularity, mitotic activity to a degree, but lack the pallisading necrosis or vascular proliferation of GBM [18, 19, 27, 69, 78, 80, 94] (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Microscopically, they show cytoplasmic and nuclear pleomorphism, hypercellularity, mitotic activity to a degree, but lack the pallisading necrosis or vascular proliferation of GBM [18, 19, 27, 69, 78, 80, 94] (Fig. 4).…”

Section: Resultsmentioning

confidence: 99%

“…Six of ten patients with cerebral anaplastic astrocytomas were treated by several modalities: (1) surgical resection as the only form of therapy [18, 69], (2) surgery plus chemotherapy [19, 80, 94], and (3) surgery followed by chemotherapy and irradiation [78]. Five of six survived no matter what form of therapy was given (Table 5).…”

Section: Resultsmentioning

confidence: 99%

“…High-grade astrocytomas are those graded III (e.g., anaplastic astrocytoma) or IV (e.g., glioblastoma) and comprise approximately 7–11 % of pediatric tumors [28]. Perinatal strocytomas vary from benign (low-grade) to malignant (high-grade) tumors [9, 18, 30, 32, 49, 51, 63, 69]. High-grade astrocytomas were more prevalent than low-grade ones in this review, 55 versus 46 % (Table 9).…”

Section: Introductionmentioning

confidence: 99%

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Perinatal (fetal and neonatal) astrocytoma: a review

Isaacs

2016

Childs Nerv Syst

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Introduction The purpose of this review is to document the various types of astrocytoma that occur in the fetus and neonate, their locations, initial findings, pathology, and outcome. Data are presented that show which patients are likely to survive or benefit from treatment compared with those who are unlikely to respond. Materials and methods One hundred one fetal and neonatal tumors were collected from the literature for study. Results Macrocephaly and an intracranial mass were the most common initial findings. Overall, hydrocephalus and intracranial hemorrhage were next. Glioblastoma (GBM) was the most common neoplasm followed in order by subependymal giant cell astrocytoma (SEGA), low-grade astrocytoma, anaplastic astrocytoma, and desmoplastic infantile astrocytoma (DIA). Tumors were detected most often toward the end of the third trimester of pregnancy. Conclusion A number of patients were considered inoperable since their tumor occupied much of the intracranial cavity involving large areas of the brain. High-grade astrocytomas were more common than low-grade ones in this review. Fetuses and neonates with astrocytoma have a mixed prognosis ranging from as low as 20 % (GBM) to a high of 90 %. The overall survival was 47/101 or 46 %.

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