Congenital anomalies associated with cleft lip and palate

Sekhon, Prabhjot; Rao, C.B.; Markus, A.F.

doi:10.1016/j.bjoms.2007.07.133

Cited by 3 publications

(2 citation statements)

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“…This malformation is involved in more than 100 syndromes, and trisomy 13 is the most frequently associated chromosomal anomaly3. In one recent series of 1623 patients with CLP, 15% had associated malformations, which were most frequent in patients with unilateral involvement of the lip and palate (37%), followed in decreasing order by isolated cleft palate (23%), bilateral CLP (20%), cleft lip with or without cleft alveolar ridge (17%), and submucosal cleft (3%)4. The most frequent location of associated malformations is the facial region (21%), followed by the ocular system, central nervous system, skeletal system, cardiovascular system, neck, auricular system, gastrointestinal system and urogenital system.…”

Section: Introductionmentioning

confidence: 99%

Three‐dimensional ultrasound diagnosis of cleft palate: ‘reverse face’, ‘flipped face’ or ‘oblique face’–which method is best?

Ten¹,

Pedregosa²,

Santacruz³

et al. 2008

Ultrasound in Obstet & Gyne

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Section: Introductionmentioning

confidence: 99%

Three‐dimensional ultrasound diagnosis of cleft palate: ‘reverse face’, ‘flipped face’ or ‘oblique face’–which method is best?

Ten¹,

Pedregosa²,

Santacruz³

et al. 2008

Ultrasound in Obstet & Gyne

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“…La mayoría de los genes relacionados con las FOF forma sindrómica tienen un papel esencial en el desarrollo del tejido conectivo y por esta razón las alteraciones congénitas que más frecuentemente están asociadas a esta entidad son las que afectan el sistema musculoesquelético. (Hwang, et al, 1998, Sekhon, et al, 2011, Mossey, et al, 2012. Este estudio es evidencia de lo anterior, pues además de ser este el sistema que más frecuentemente se ve afectado, en lo que anomalías congénitas se refiere; la DDC, una patología del tejido conectivo presenta una asociación estadísticamente significativa con las FOF sindrómicas.…”

Section: Discussionunclassified

Aspectos clínicos asociados a fisuras orofaciales sindrómicas en una población colombiana

Urueña¹

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Fetal Diagnosis of Cleft Lip

Liu

Freitas²,

Magriples³

et al. 2008

Journal of Craniofacial Surgery

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Previous studies have suggested that most fetuses diagnosed prenatally with cleft lip have multiple associated anomalies, that fetuses with isolated cleft lip/palate are uncommon, and that their ultimate outcome is poor (Lopoo, 1999). However, our clinical experience failed to make a similar connection. The purpose of this study was to examine the natural history and current outcomes of fetuses diagnosed with cleft lip. A retrospective study was performed on all patients undergoing fetal ultrasonography over a 7-year period (1993-2001) in a tertiary referral center. All patients who had a fetal diagnosis of cleft lip were reviewed (N = 57). Fifty-seven fetuses with cleft lip were identified. Forty-three of 57 patients have complete records. Of these, 18 patients (43%) had terminations for associated severe malformations. Three fetuses (7%) had intrauterine or neonatal demise. The remainder, 22 fetuses (53%) survived to term. Of this group, 18 (82%) of 22 infants were diagnosed postnatally with isolated cleft lip/palate and no associated anomalies. Only 4 of 22 had associated anomalies. All recorded terminations were performed with known karyotyping. We demonstrate that a significant percentage of fetuses diagnosed ultrasonographically with cleft lip/palate in our study were isolated and that this subset of patients has an excellent prognosis and outcome. This may provide further or alter implications for genetic counseling and management.

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Congenital anomalies associated with cleft lip and palate

Cited by 3 publications

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Three‐dimensional ultrasound diagnosis of cleft palate: ‘reverse face’, ‘flipped face’ or ‘oblique face’–which method is best?

Three‐dimensional ultrasound diagnosis of cleft palate: ‘reverse face’, ‘flipped face’ or ‘oblique face’–which method is best?

Aspectos clínicos asociados a fisuras orofaciales sindrómicas en una población colombiana

Fetal Diagnosis of Cleft Lip

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