Congenital Bleeding: Autosomal Recessive Disorders

Peyvandi, Flora; Mannucci, Pier Mannuccio

doi:10.1002/9780470987056.ch50

Cited by 1 publication

(1 citation statement)

References 43 publications

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“…Proper levels of factor XIII are essential for proper wound healing, hemostasis, and the maintenance of pregnancy. [8][9] The most common polymorphism affecting the FXIII gene involves a G-to-T transition (FXIII G103T) in exon 2 of the gene encoding for FXIIIA, which leads to a valine (V)-to-leucine (L) substitution at amino acid 34. The FXIII G103T variant does not result in a change in the plasma concentration of FXIII, but the amino acid change may modify FXIII activity.…”

Section: Introductionmentioning

confidence: 99%

Detection of factor XIII polymorphism among Sudanese women with recurrent spotanuse abortion, Khartoum state, Sudan 2021

Umar¹

2022

SPR

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Recurrent Pregnancy Loss (RPL) is recognized as the loss of a clinical pregnancy before 20 completed weeks of gestational age. This was a descriptive-analytical case-control study conducted at the research laboratory of the national centre of neurological sciences (NCNS), Khartoum, Sudan. The study aimed to detect factor XIII gene polymorphisms among Sudanese women with recurrent spontaneous abortion. Women with more than three recurrent abortions were included in this study as cases and those healthy women with no history of abortion at reproductive age were included as controls. From each participant 3 ml of venous blood was gathered in sterile containers. The factor XIII gene was amplified using conventional PCR. All cases were positive 44 (100%) while 30 (60%) were positivein the control group and 20 (40%) were negative. There was a significant difference between the PCR result of the cases and that of controls (P= 0.000). A high frequency of factor XIII gene polymorphisms was found in women with recurrent spontaneous abortion than those healthy women at reproductive age without abortion.

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Section: Introductionmentioning

confidence: 99%

Detection of factor XIII polymorphism among Sudanese women with recurrent spotanuse abortion, Khartoum state, Sudan 2021

Umar¹

2022

SPR

View full text Add to dashboard Cite

show abstract

Congenital Bleeding: Autosomal Recessive Disorders

Cited by 1 publication

References 43 publications

Detection of factor XIII polymorphism among Sudanese women with recurrent spotanuse abortion, Khartoum state, Sudan 2021

Detection of factor XIII polymorphism among Sudanese women with recurrent spotanuse abortion, Khartoum state, Sudan 2021

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