Congenital brain oedema of Hereford calves

Jolly, RD

doi:10.1002/path.1711140404

Cited by 33 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Congenital status spongiosus has been reported in neonatal Angus, Jersey, and Shorthorn cattle. 25,26 Congenital ataxia of Jersey calves is associated with status spongiosus and reduced myelin of the cerebellum, along with the absence or reduction in size of cerebellar roof and dentate nuclei. 25 Status spongiosus with hypomyelinogenesis was seen in cross-bred Angus-Shorthorn calves, predominantly affecting cerebellum and medulla oblongata.…”

Section: Discussionmentioning

confidence: 99%

“…1,2,[5][6][7]17,27,29,30,37 It has not been conclusively demonstrated in cattle, although congenital brain edema of Hereford cattle in New Zealand and congenital hypomyelinogenesis in Hereford cattle in the United Kingdom may be forms of aspartoacylase deficiency. 6,13,14,26 The disease in people is inherited as a homozygous recessive trait and results in the accumulation of Nacetylaspartic acid in brain with disruption of myelin, formation of Alzheimer type II cells, and vacuolation of protoplasmic astrocytes. 17 There are at least 10 missense and nonsense mutations in the gene for aspartoacylase associated with the disease in Ashkenazi and in non-Jewish patients.…”

Section: Discussionmentioning

confidence: 99%

“…13,14 Other, less well-characterized forms of congenital or perinatal status spongiosus occur in cattle. 19,25,26,33,40 These vary in time of onset, clinical presentation and progression, presence or absence of gray matter changes, presence and severity of hypomyelination or dysmyelination, and whether spongy change is diffuse or localized.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Status Spongiosus of White Matter in Newborn Gelbvieh-Cross Calves

et al. 2005

View full text Add to dashboard Cite

Abstract. Various forms of status spongiosus occur in neonatal cattle, the best characterized of which is due to mutations of the branched-chain alpha-keto acid dehydrogenase complex (BCKD), resulting in bovine maple syrup urine disease (MSUD, branched-chain ketoaciduria). A distinctive neurological syndrome was identified between 1998 and 2003 in 9 calves in a 250-cow stabilized Gelbvieh-Red Angus herd. Both sexes were affected (6 heifers, 3 bulls), with a low annual incidence (3 cases in 1998; no cases in 1999; 2 cases in 2000; 2 in 2001; 1 in 2002; 1 in 2003). Affected calves were born full-term, unable to stand, and had constant whole-body tremors when stimulated. Animals remained in lateral recumbency until death or euthanasia; the longest survival time was 10 days postpartum. The principal histological change in 2 affected calves was diffuse, moderately severe bilaterally symmetrical status spongiosus with Alzheimer type II cells throughout the white matter of the brain. Myelin deficits were not evident and vacuoles were due to cleaved myelin sheaths. Neither recognized mutation of MSUD was identified in the E1a subunit of BCKD in 2 affected calves, 8 dams that gave birth to affected calves, a grand-dam of 3 affected calves, or a sire of 1 calf. Amino acid analysis of serum from 1 affected calf revealed normal concentrations of branched-chain amino acids, indicating that this disease is distinct from MSUD. The genetic and biochemical basis for the disorder, provisionally named congenital status spongiosus of Gelbvieh-cross cattle, is undetermined. The pattern of inheritance was not established.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Status Spongiosus of White Matter in Newborn Gelbvieh-Cross Calves

et al. 2005

View full text Add to dashboard Cite

show abstract

“…In addition, maple syrup urine disease (MSUD), autosomal recessive disorder due to hereditary metabolic disturbance of branched-chain amino acid (BCAA), results in status spongiosis in the CNS [1]. Even in calves, similar hereditary or metabolic CNS disorders including MSUD and congenital cerebral edema have been reported in the Hereford breed [3][4][5][6][7]12].In Japan, the first case of BSE was diagnosed in September 2001. Then, mass-screening system based on a detection of abnormal prion protein (PrP) by ELISA has been adopted at meat inspection and livestock hygiene centers since October 2001.…”

mentioning

confidence: 99%

“…These congenital disorders present common clinical course that calves are affected in the first week of life with severe neurological signs of recumbency and opisthotonos. Congenital cerebral edema was first reported by Jolly in New Zealand [7]. Histopathological features are characterized by hypomyelinogenesis, and hydropic degeneration of astrocytes and oligodendrocytes resulting in status spongiosis in the CNS.…”

mentioning

confidence: 99%

A Neurological Disease with Spongy Degeneration in a Newborn Japanese Black Calf

Kato

Uchida

Murakami

et al. 2005

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. A Japanese Black calf, 3 day-old male, showed severe ataxia, lateral recumbency, and opisthotonos at the birth. Histopathological examinations revealed severe status spongiosis throughout the central nervous system. Numerous vacuoles within the neuropile varying in size and shape were observed in both formalin-fixed paraffin and cryostat sections. In the lesions, a limited number of spheroids and macrophages were observed within the myelin sheaths with very mild astrogliosis. These vacuoles were negative for both periodic acid Schiff and Sudan black stains. The clinical and histopathological features were almost in conformity with those of bovine maple syrup urine disease (MSUD). Although we could not confirm completely the etiology, congenital hereditary neurological diseases including MSUD are considerable as the possible disease entry in the present case. KEY WORDS: bovine, maple syrup urine disease, spongy degeneration.J. Vet. Med. Sci. 67(10): 1067-1070, 2005 Spongy degeneration in the central nervous system (CNS) is the most characteristic morphological feature of prion diseases in several animal species. Among them, the diagnosis and disclose of ovine or caprine scrapie and bovine spongiform encephalopathy (BSE) are very important especially in veterinary fields [13]. However, spongiform change is not specific feature for prion diseases, but other several metabolic or hereditary degenerative diseases also cause similar changes in the CNS. In humans, Canavan's disease, autosomal recessive disorder based on Nacetylaspartic acid metabolism alteration, has been known to cause spongy degeneration in the brain [2,9]. In addition, maple syrup urine disease (MSUD), autosomal recessive disorder due to hereditary metabolic disturbance of branched-chain amino acid (BCAA), results in status spongiosis in the CNS [1]. Even in calves, similar hereditary or metabolic CNS disorders including MSUD and congenital cerebral edema have been reported in the Hereford breed [3][4][5][6][7]12].In Japan, the first case of BSE was diagnosed in September 2001. Then, mass-screening system based on a detection of abnormal prion protein (PrP) by ELISA has been adopted at meat inspection and livestock hygiene centers since October 2001. The final diagnoses were based on the results of both Western blot examination and immunohistochemistry. Since the screening system for BSE has applied for all meat cattle and all ill or dead cattle over 24 month-old, hereditary degenerative disorders other than prion diseases might not be serious differential diagnosis to rule out. Besides, when very young calves developed spongy degeneration in the brain, these diseases could be very important. In addition, status spongiosis in the CNS may be induced by heavy metal poisoning such as triethyl tin [10]. It has been also known that spongiosis-like vacuolar changes are often produced by inadequate tissue processing for paraffin sections.The present study describes pathological features of a Japanese Black calf with severe congenital neurological ...

show abstract

Congenital, familial, and genetic disorders

2022

Large Animal Neurology

View full text Add to dashboard Cite

Congenital brain oedema of Hereford calves

Cited by 33 publications

References 5 publications

Status Spongiosus of White Matter in Newborn Gelbvieh-Cross Calves

Status Spongiosus of White Matter in Newborn Gelbvieh-Cross Calves

A Neurological Disease with Spongy Degeneration in a Newborn Japanese Black Calf

Congenital, familial, and genetic disorders

Contact Info

Product

Resources

About