Congenital cardiac abnormalities in monozygotic twins. Report and review of the literature.

Seides, Stuart F.; Shemin, Richard J.; Morrow, Andrew G.

doi:10.1136/hrt.42.6.742

Cited by 11 publications

(13 citation statements)

References 11 publications

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“…Monozygotic twins have an increased risk of congenital cardiac malformation, and this is even higher in TTTS (6.9% with TTTS compared with 2.3% without TTTS and 0.6% in the general population). 6 The incidence of congenital heart malformations is especially high in recipient twins (11.9%), with pulmonary stenosis and endocardial fibroelastosis being the most frequent diagnoses. 3,4 In 2005, we had 90 twin pairs admitted to our neonatal intensive care unit (NICU), of which 28 (31%) were MCDA twins.…”

Section: Discussionmentioning

confidence: 99%

“…Cardiac malformations are more common in twin pregnancies compared with singleton pregnancies, [1][2][3][4] and there is a higher incidence in monozygotic twins compared with dizygotic twins. [4][5][6] Overall, the prevalence in monochorionic diamniotic (MCDA) pregnancies is 3.8%, sevenfold that in the general population, with the lesions usually discordant for the twin pair. 3 Although the aetiology is poorly understood and is traditionally considered multifactorial, the monozygotic twinning process itself might in part be responsible for the increased incidence.…”

mentioning

confidence: 99%

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Twin–twin transfusion syndrome, coarctation of the aorta and hypoplastic aortic arch: A case series report

Boom

Battin

Hornung

2010

J Paediatrics Child Health

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Twin–twin transfusion syndrome, coarctation of the aorta and hypoplastic aortic arch: A case series report

Boom

Battin

Hornung

2010

J Paediatrics Child Health

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“…Regarding the latter ones: the prevalence of an inborn heart disease, if either of the twins is affected, is considerably higher for a monozygotic twin sibling compared to a dizygotic twin sibling (Mitchell et al, 1971; Wang et al, 2012). Additionally, if in a monozygotic twinship both twins exhibit any congenital heart defect, then with over 90% incidence both will have the same heart malformation (Seides et al, 1979). …”

Section: Introductionmentioning

confidence: 99%

Role of connexins in human congenital heart disease: the chicken and egg problem

Salameh¹,

Blanke²,

Dähnert³

2013

Front. Pharmacol.

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Inborn cardiac diseases are among the most frequent congenital anomalies and are the main cause of death in infants within the first year of age in industrialized countries when not adequately treated. They can be divided into simple and complex cardiac malformations. The former ones, for instance atrial and ventricular septal defects, valvular or subvalvular stenosis or insufficiency account for up to 80% of cardiac abnormalities. The latter ones, for example transposition of the great vessels, Tetralogy of Fallot or Shone’s anomaly often do not involve only the heart, but also the great vessels and although occurring less frequently, these severe cardiac malformations will become symptomatic within the first months of age and have a high risk of mortality if the patients remain untreated. In the last decade, there is increasing evidence that cardiac gap junction proteins, the connexins (Cx), might have an impact on cardiac anomalies. In the heart, mainly three of them (Cx40, Cx43, and Cx45) are differentially expressed with regard to temporal organogenesis and to their spatial distribution in the heart. These proteins, forming gap junction channels, are most important for a normal electrical conduction and coordinated synchronous heart muscle contraction and also for the normal embryonic development of the heart. Animal and also some human studies revealed that at least in some cardiac malformations alterations in certain gap junction proteins are present but until today no particular gap junction mutation could be assigned to a specific cardiac anomaly. As gap junctions have often been supposed to transmit growth and differentiation signals from cell to cell it is reasonable to assume that they are somehow involved in misdirected growth present in many inborn heart diseases playing a primary or contributory role. This review addresses the potentional role of gap junctions in the development of inborn heart anomalies like the conotruncal heart defects.

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“…As in our case, concordance for the specificity of cardiac defects is very high [1,11]. Each of these individuals had virtually identical complex cardiac anomalies (combined aortic and mitral atresia, sealed foramen ovale, and partial anomalous pulmonary venous connection).…”

Section: Observationsmentioning

confidence: 77%

Aortic valvular atresia

1982

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The pathological anatomy of 109 specimens of aortic valvular atresia was reviewed for the purpose of identifying the cardiovascular anomalies associated with that condition. We found the most commonly associated anomaly to be coarctation of the aorta, which was present in 71 percent of our cases and judged to be hemodynamic significance in one-third of the involved cases. Other associated anomalies, in order of decreasing frequency, were mitral atresia, anomalous systemic and pulmonary venous connections, abnormalities of branching of the aortic arch, and ventricular septal defect. The study demonstrated that aortic atresia is associated with a significant incidence of other cardiovascular anomalies. Additional anomalies, when present, may complicate emerging attempts at surgical correction of this condition.

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Congenital cardiac abnormalities in monozygotic twins. Report and review of the literature.

Cited by 11 publications

References 11 publications

Twin–twin transfusion syndrome, coarctation of the aorta and hypoplastic aortic arch: A case series report

Twin–twin transfusion syndrome, coarctation of the aorta and hypoplastic aortic arch: A case series report

Role of connexins in human congenital heart disease: the chicken and egg problem

Aortic valvular atresia

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