Congenital Cartilaginous Rests of the Neck (Wattles)

Coras, Brigitte; Hafner, Christian; Roesch, Alexander; Vogt, Thomas; Landthaler, Míchael; Hohenleutner, Ulrích

doi:10.1111/j.1524-4725.2005.31218

Cited by 11 publications

(6 citation statements)

References 6 publications

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“…Similar structures were also occasionally reported in other species such as sheep, pigs and humans (Darwin ; Mouquet ; Fröhner ; Lush ; Schumann ; Weissengruber ; Coras et al . ; Nasser et al . ).…”

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confidence: 99%

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Wattles in goats are associated with theFMN1/GREM1region on chromosome 10

et al. 2015

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SummaryThe presence of congenital appendages (wattles) on the throat of goats is supposed to be under genetic control with a dominant mode of inheritance. Wattles contain a cartilaginous core covered with normal skin resembling early stages of extremities. To map the dominant caprine wattles (W) locus, we collected samples of 174 goats with wattles and 167 goats without wattles from nine different Swiss goat breeds. The samples were genotyped with the 53k goat SNP chip for a subsequent genome‐wide association study. We obtained a single strong association signal on chromosome 10 in a region containing functional candidate genes for limb development and outgrowth. We sequenced the whole genomes of an informative family trio containing an offspring without wattles and its heterozygous parents with wattles. In the associated goat chromosome 10 region, a total of 1055 SNPs and short indels perfectly co‐segregate with the W allele. None of the variants were perfectly associated with the phenotype after analyzing the genome sequences of eight additional goats. We speculate that the causative mutation is located in one of the numerous gaps in the current version of the goat reference sequence and/or represents a larger structural variant which influences the expression of the FMN1 and/or GREM1 genes. Also, we cannot rule out possible genetic or allelic heterogeneity. Our genetic findings support earlier assumptions that wattles are rudimentary developed extremities.

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confidence: 99%

“…Wattles were alternatively designated as appendices colli, cervical chondrocutaneous remnants or congenital cartilaginous rest of neck (Weissengruber ; Coras et al . ; Nasser et al . ).…”

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confidence: 99%

Wattles in goats are associated with theFMN1/GREM1region on chromosome 10

et al. 2015

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“…These malformations include microtia, stenosis of the external ear canal, and branchiogenic fistulae. In addition Goldenhar, Treacher-Collins, Townes-Brocks, Wolf-Hischhorn and Delleman syndromes can be associated [4][5][6][7][8][9]. Diagnosis is confirmed by histological examination.…”

Section: Discussionmentioning

confidence: 95%

“…Shave excision is not recommended because it may leave the cartilage exposed and cause subsequent complications [7][8][9]. The lesion may be attached to underlying fascia by a fibrous band but can be easily excised since it is neither fistulous nor cystic [7][8][9]. Lesions that do not have fistulous tracts or connections with deeper structures can be carefully excised at the superficial musculature.…”

Section: Discussionmentioning

confidence: 99%

Congenital cartilaginous rest of the neck in a boy

Blattner

Ross²,

Bohlke³

et al. 2016

DOJ

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“…These remnants have been suggested to mark unsuspected branchial sinus (Christensen and Barr, 1985; Coras et al, 2005). In none of the reviewed articles was there any evidence of sinuses or cysts associated with the cervical remnant.…”

Section: Discussionmentioning

confidence: 99%