Congenital Cataracts and Genetic Anomalies of the Lens

Drack, Arlene V.; Rabinowitz, Yaron S.; Cotlier, Edward

doi:10.1016/b978-0-12-383834-6.00146-4

Emery and Rimoin's Principles and Practice of Medical Genetics 2013

DOI: 10.1016/b978-0-12-383834-6.00146-4

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Congenital Cataracts and Genetic Anomalies of the Lens

Arlene V. Drack

Yaron S. Rabinowitz

Edward Cotlier

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2015

2024

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Cited by 2 publications

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“…13–15 It is also known that ocular trauma and lens subluxation are more likely in younger individuals, making it necessary to know about the long-term outcomes of this surgical technique. 16–18…”

mentioning

confidence: 99%

“…[13][14][15] It is also known that ocular trauma and lens subluxation are more likely in younger individuals, making it necessary to know about the long-term outcomes of this surgical technique. [16][17][18] Our study attempts to fill these lacunae in the literature, and we describe the long-term (10 years and longer) outcomes of sutured SF IOL implantation. We describe both the visual as well as anatomical outcomes and safety profile of this surgery performed in the setting of inadequate capsular support due to a heterogeneous group of conditions, including complicated cataract surgery, trauma, and ectopia lentis.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Ten-year results of scleral-fixated intraocular lens implantation: outcomes of ab externo scleral fixation with 10-0 polypropylene suture

Desai,

Pappuru,

Tyagi

2024

J Cataract Refract Surg

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Purpose: To describe long-term visual and anatomical outcomes of sutured scleral-fixated intraocular lens (SF IOL) implantation. Setting: Tertiary eyecare hospital in India. Design: Retrospective interventional noncomparative study. Methods: Postoperative change in corrected distance visual acuity (CDVA) and occurrence of complications were assessed from the patient medical records. Long-term SF IOL survival rates and factors affecting the occurrence of postoperative IOL-related complications were assessed. Patients with postoperative follow-up less than 10 years or incomplete medical records were excluded. Results: 64 eyes of 53 patients were included. Follow-up duration was 11.4 ± 1.2 years. Mean preoperative CDVA was 0.71 ± 0.43 logMAR (Snellen equivalent: 6/30), and mean CDVA at the final visit was 0.52 ± 0.49 logMAR (Snellen equivalent: 6/18) (P < .01). 48% cases had CDVA of 6/12 or better at the last follow-up. 58% cases had coexistent ocular pathology affecting the final visual outcome. IOL and suture-related complications were the commonest and included IOL decentration (17% cases), IOL drop (14%), and suture exposure (6%). The probability of IOL survival (postoperative period without IOL-related complications) was 90.6% at 8 years and 81.2% at 10 years (Kaplan-Meier analysis). Occurrence of postoperative IOL-related complications was unaffected by patient sex, age, indication for surgery (trauma or other), previous intraocular surgery, or technique of scleral fixation (2-point or 4-point) (multivariate regression analysis). Conclusions: Although sutured SF IOL implantation is viable with favorable long-term visual outcomes, there is a risk of postoperative IOL-related complications. Occurrence of postoperative IOL-related complications is unaffected by patient and ocular factors.

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confidence: 99%

mentioning

confidence: 99%

Ten-year results of scleral-fixated intraocular lens implantation: outcomes of ab externo scleral fixation with 10-0 polypropylene suture

Desai,

Pappuru,

Tyagi

2024

J Cataract Refract Surg

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Pediatric genetic disorders of lens

Nihalani

2015

J Pediatr Genet

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Pediatric genetic disorders of lens include various cataractous and non-cataractous anomalies. The purpose of this review is to help determine the genetic cause based on the lens appearance, ocular and systemic associations. Children with bilateral cataracts require a comprehensive history, ophthalmic and systemic examination to guide further genetic evaluation. With advancements in genetics, it is possible to determine the genetic mutations and assess phenotype genotype correlation in different lens disorders. The genetic diagnosis helps the families to better understand the disorder and develop realistic expectations as to the course of their child's disorder.

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Congenital Cataracts and Genetic Anomalies of the Lens

Cited by 2 publications

References 104 publications

Ten-year results of scleral-fixated intraocular lens implantation: outcomes of ab externo scleral fixation with 10-0 polypropylene suture

Ten-year results of scleral-fixated intraocular lens implantation: outcomes of ab externo scleral fixation with 10-0 polypropylene suture

Pediatric genetic disorders of lens

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