Congenital cervical neuroblastoma

Abstract

Primary congenital cervical neuroblastomas are very rare. A history of upper aerodigestive compromise with Horner syndrome can be of value for the early diagnosis of this lesion. Congenital neuroblastomas usually have a favorable outcome. Like all the other clinically relevant groups of neuroblastomas, management should take into consideration the biological findings of each tumor, which predicts outcome than other clinical findings.

Neonatal neck mass with associated Horner Syndrome: A unique presentation of neuroblastoma

“…Yet, approximately 60-70% of neuroblastomas diagnosed in the perinatal period are non-secretory [2]. In a review of 56 children presenting with Horner syndrome, none of the 4 cases of neuroblastoma had elevated urinary catecholamines [15].…”

“…Patients may present with a neck mass, stridor, feeding difficulties, or respiratory distress [2]. Other presenting symptoms commonly include fatigue, anorexia, weight loss, fever, joint pain, abdominal distension, emesis, diarrhea, subcutaneous nodules, bone pain, and elevated blood pressure depending on primary tumor site and the presence of metastases [3].…”

Retropharyngeal neuroblastoma in a neonate: case report and literature review

“…Cervical NB usually presents with stridor, dyspnea, difficulty in swallowing, or Horner's syndrome in association with a smooth, firm mass [4,5], and is reported to have a favorable outcome [6]. However, cervical NB in neonates is extremely rare and its clinical characteristics are not clearly understood.…”

Estridor inspiratorio en neonato por neuroblastoma cervical. Descripción de un caso

“…El diagnóstico diferencial de masas cervicales congénitas incluye: tumores vasculares, malformaciones linfáticas, quistes branquiales, defectos cervicales del tubo neural, tejido neuroglial heterotópico, así como tumores sólidos, incluyendo teratomas, neuroblastomas, tumores rabdoides o sarcomas [4]. Muchos son asintomáticos y son descubiertos incidentalmente por los pacientes o en el examen físico, mientras otros precisan de atención médica precoz porque producen efecto masa, compromiso de la vía aerodigestiva, fiebre o síntomas relacionados con infección aguda, enfermedad inflamatoria, dolor o deformidades estéticas [5].…”