Congenital Chikungunya—A Cause of Neonatal Hyperpigmentation

Vasani, Resham; Kanhere, Sujata; Chaudhari, Kushagra; Phadke, Varsha; Mukherjee, Priyashree; Gupta, Swati; Kasliwal, Chetan; Poojary, Shital

doi:10.1111/pde.12650

Cited by 24 publications

(23 citation statements)

References 7 publications

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“…1,5 Hyperpigmentation areas in the face, chest, shoulder, and the palm of the hand may also occur. 7 In a previous study, 1,400 pregnant women were enrolled during a CHIKV outbreak in the Reunion Island (628 uninfected, 658 infected during pregnancy, 27 infected before pregnancy, and 87 infected on unknown dates). Outcomes (cesarean deliveries, obstetric hemorrhaging, preterm births, and stillbirths after 22 weeks, birth weight, congenital malformations, and newborn admissions) were similar between the groups.…”

Section: Casementioning

confidence: 99%

Congenital Chikungunya Virus Infection after an Outbreak in Salvador, Bahia, Brazil

Lyra

Campos

Bandeira

et al. 2016

AJP Rep

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There is little information about the congenital chikungunya virus (CHIKV) transmission. We describe two cases of well-documented congenital CHIKV infection in Salvador-Brazil, where CHIKV has been identified since 2014. The outbreak in the city led to the clinical CHIKV diagnoses of both pregnant women 2 days before delivery. Urine and blood samples from the mothers and newborns were collected and tested for reverse transcription-polymerase chain reaction (PCR) analysis for Zika, dengue, and CHIKV. Both neonates and mothers had positive urine and serum PCR results for CHIKV. The newborns had significant perinatal complications and were admitted to the neonatal intensive care unit. The purpose of our case report is to show how severe congenital CHIKV infection can be and the importance to include CHIKV infection in the differential diagnosis of neonatal sepsis when mothers have clinical signs of the disease and live in an affected area.

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Section: Casementioning

confidence: 99%

Congenital Chikungunya Virus Infection after an Outbreak in Salvador, Bahia, Brazil

Lyra

Campos

Bandeira

et al. 2016

AJP Rep

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“…However, evidence suggested that viable infective virus is excreted in the saliva of monkeys, mice, and humans, and it could be a source of infection particularly in immunocompromised patients [32,33]. Vertical transmission has also been reported [34,35]. Despite some studies failed to show effect of CHKV infection during pregnancy on major obstetrical outcomes or congenital anomalies, long-term follow-up studies have reported poor neurocognitive outcomes of newborns and even poorer results in patients with neonatal CHIKV encephalopathy [36,37].…”

Section: Pathogenesis and Disease Transmissionmentioning

confidence: 99%

Chikungunya, a Global Threat Currently Circulating in Latin America

Rodríguez‐Morales¹,

Cardona-Ospina²,

Villamil-Gómez³

2016

Current Topics in Chikungunya

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Chikungunya fever CHIK is a highly important arbovirosis currently established in Latin "merica and the Caribbean L"C its acute and chronic burden is an overlooked issue for policy makers. Disease spread control and proper management of chronic-derived sequelae do not seem like a realistic goal in short-and mid-term. The CHIKV circulating in the Western Hemisphere is closely related to strains from Philippines, China, and Yap Federated States of Micronesia , and vertical and horizontal transmission of infection has been reported. Pathogenesis is still not well understood, and vaccines are under development yet. Here, we provide a summary of information regarding L"C spread of the disease from a public health, clinical and molecular perspective, particularly from the experience in Colombia.

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“…There are differences in the clinical presentation of infants and adults with chikungunya. Infants have an abrupt onset of fever lasting 1 day, followed by the development of maculopapular rash [10]. The common sites of pigmentation in chikungunya fever include the nose, trunk, face, shoulders (shawl-like distribution), and palms.…”

Section: Resultsmentioning

confidence: 99%

“…Chikungunya can be added to the list of viral infections that can lead to fetal demise or, when present during labor and delivery, can cause neonatal disease with cutaneous signs. Vasani et al [10] reported a case of 12 day old neonate presented with ill-defined dark pigmentation over the centrofacial area with flagellate pigmentation on the trunk and patchy pigmentation on the extremities. The mother had a history of fever starting a week before delivery and continuing for 3 days in the postpartum period.…”

Section: Post-chikungunya Pigmentation In a Neonatementioning

confidence: 99%

“…It is proposed that the Chikungunya virus may be triggering the intraepidermalmelanin dispersion or retention and presence of melanophagesseen on histology may be the cause of persistent pigmentation. The Chikungunya virus IgM antibodies are detectable on an average of 3-5 days after infection using ELISA and remain positive for few weeks to 3 months [10].…”

Section: Post-chikungunya Pigmentation In a Neonatementioning

confidence: 99%

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Study of cutaneous manifestation of chikungunya and its serological correlation

Shinde¹,

Popere

2018

Int Jour of Biomed Res

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Aim: To assess the hyperpigmentation after fever and joint pain as a cutaneous marker of chikungunya fever and to assess with serological correlation. Methods: A total of 15 patients comprised of 9 males, 6 females and neonate have aged between 14 days to 60 years presented with the pigmentation after the fever subsided were enrolled in the study. The diagnosis of chikungunya was made by detecting virus specific IgM ELISA in the serum. Results: Serological immunoglobulin M enzyme -linked immunosorbent assay (IgM ELISA) test or chikungunya virus was positive in all the patients. Generalized dark coloured pigmentation was the most common finding after the fever subsided. On examination, out of 15 cases, in most of the cases, hyperpigmentation was observed all over the body with the facial involvement. Few cases showed pigmentation over nose, centre of upper lip, on palm, sole, eyelid, dorsum, centrofacial, reticulate pattern on the face and blotchy pigmentation. Conclusion:The presence of pigmentation after fever and joint pain helps to make a retrospective diagnosis of chikungunya fever and this may be considered as a cutaneous marker of chikungunya fever in recent past.

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Congenital Chikungunya—A Cause of Neonatal Hyperpigmentation

Cited by 24 publications

References 7 publications

Congenital Chikungunya Virus Infection after an Outbreak in Salvador, Bahia, Brazil

Congenital Chikungunya Virus Infection after an Outbreak in Salvador, Bahia, Brazil

Chikungunya, a Global Threat Currently Circulating in Latin America

Study of cutaneous manifestation of chikungunya and its serological correlation

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