Congenital cholesteatoma of occipital bone or intradiploic epidermoid cyst? One and the same disease

Clark, Matthew; Pretorius, Pieter; Beaumont, D; Milford, C. A.

doi:10.1017/s0022215108003083

Cited by 9 publications

(12 citation statements)

References 8 publications

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“…Among these alternative diagnoses, EAC cholesteatoma is the most difficult disease to differentiate clinically, radiologically, and histopathologically from epidermoid cyst [ 4 ]. Although Clark, et al [ 11 ] suggested that epidermoid cyst and cholesteatoma are the same disease entity because they are indistinguishable histopathologically as well as radiologically, these are different diseases. EAC cholesteatoma is characterized by keratin debris, hyperproliferative epithelium, intact basement membrane, and accumulation of inflammatory cells [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Cholesteatoma destroys the bone through osteoclastic bone resorption and chronic inflammation, whereas the epidermoid cyst seems to erode adjacent bone through pressure necrosis [ 10 ]. Clark, et al [ 11 ] suggested that epidermoid cyst and cholesteatoma are the same disease entity because they are indistinguishable histopathologically as well as radiologically. Lee [ 4 ] described different findings in an imaging study that compared cholesteatoma and epidermoid cysts.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Characteristics of Epidermoid Cysts of the External Auditory Canal

et al. 2016

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Background and ObjectivesThe epidermoid cyst is a common benign disease of the skin caused by inflammation of hair cortex follicles and proliferation of epidermal cells within the dermis or superficial subcutaneous tissue. The purpose of this study was to investigate the characteristics of epidermoid cysts of the external auditory canal (EAC) by analyzing the clinical and radiologic features.Subjects and MethodsThe clinical records were retrospectively reviewed for patients diagnosed with epidermoid cyst of the EAC from March 2004 to December 2013. The epidermoid cysts were diagnosed clinically by endoscopy and microscopy examinations and by temporal bone CT images, and were confirmed by histopathologic examination. Characteristics of epidermoid cysts in bony EAC and cartilaginous EAC were compared.ResultsEight patients had an epidermoid cyst in the bony EAC and nine patients had one in the cartilaginous EAC. Swelling and otalgia were common symptoms, but 47% of cysts were found incidentally. The mean age of patients was 49.6 years (age range, 26-67 years) in the bony EAC cases and 26.1 years (age range, 6-57 years) in the cartilaginous EAC cases. The mean size of the epidermoid cyst was 3.50 mm (size range, 2-7 mm) in the bony EAC cases and 9.55 mm (size range, 2-20 mm) in the cartilaginous EAC cases.ConclusionsComparison of epidermoid cysts of the bony EAC and the cartilaginous EAC revealed that epidermoid cysts of the bony EAC is usually found incidentally, arose in older patients and had smaller size.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of Epidermoid Cysts of the External Auditory Canal

et al. 2016

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“…It is indistinguishable from a cranial cholesteatoma histologically and radiologically. Clark, et al 15) proposed that a CC and intradiploic epidermoid cyst are one and the same condition. All three conditions (i.e., congenital cholesteatoma localized only to mastoid bone, cranial cholesteatoma, and intradiploic epidermoid cyst) are extremely rare and we believe that there is no better way to explain their origins than the implantation theory.…”

Section: Discussionmentioning

confidence: 99%

Congenital Cholesteatoma Localized to the Tip of the Mastoid Bone: A Case Report and Possible Etiology

et al. 2014

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Congenital cholesteatomas of mastoid origin are extremely rare. We reported one in 2007 and experienced an additional case. A male presented with a 5-month history of right-sided ear discharge. Computed tomography of the temporal bone showed a soft tissue density occupying the mastoid tip. At surgery, the cholesteatoma sac was completely isolated from the mastoid antrum and lateral air cell in the mastoid tip area. We now doubt the rarity of this entity. With a brief literature review, we consider how the cholesteatoma localizes to the tip of the mastoid bone.

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“…Both congenital cholesteatoma and intradiploic epidermoid cyst show keratinized squamous epithelia, including keratin, and are hard to differentially diagnose with MRI, because both have a low signal on T1-weighted images and a high signal on T2-weighted images [2][3][4][5][9][10][11] . Our case is reported to be a back-side tumor that blocked the EAC inlet according to the computed tomography and is different from general cholesteatoma.…”

Section: Discussionmentioning

confidence: 99%

“…They can grow to be gigantic without any neurological symptoms [3] . Occasionally, once they become sizeable, they can cause headaches and, more rarely, increased intracranial pressure, seizure, and on-going hemiparesis and other local neurological signs [10,11] . Other problems that can occur include bone resorption near the intradiploic epidermoid cyst due to middle ear cavity or cholesteatoma infection, interleukin-1, fibroblast production, collagenase, and granulocyte-macrophage colony-stimulating factor secretion, etc [2] .…”

Section: Discussionmentioning

confidence: 99%

Large Intradiploic Epidermoid Cyst of the Temporal Bone

2014

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Intradiploic epidermoid cyst of the skull, despite being rare and representing less than 1% of all intracranial tumors, is a benign lesion that is derived from an ectodermal cell rest within the cranium. The frontal and parietal bones are the most common sites for the cyst; however, the temporal bone, although rarely, is also involved. Intradiploic epidermoid cysts have slow growth rates and often grow to enormous sizes without producing any measurable neurological symptoms. For treatment, a complete removal of the cyst with its capsule is important to avoid recurrence. Very rare malignant transformations of the cysts have been reported, generally in cases with repeated recurrences or infections. A 16-year-old female patient was diagnosed with a temporal bone intradiploic epidermoid cyst behind the left mastoid cavity, which was successfully removed through a transmastoid approach.

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Congenital cholesteatoma of occipital bone or intradiploic epidermoid cyst? One and the same disease

Abstract: Congenital cholesteatomas and intradiploic epidermoid cysts are indistinguishable both histologically and radiologically, and would appear to be the same disease.

Cited by 9 publications

References 8 publications

Clinical Characteristics of Epidermoid Cysts of the External Auditory Canal

Clinical Characteristics of Epidermoid Cysts of the External Auditory Canal

Congenital Cholesteatoma Localized to the Tip of the Mastoid Bone: A Case Report and Possible Etiology

Large Intradiploic Epidermoid Cyst of the Temporal Bone

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