Congenital Craniopharyngioma: A Role for Imaging in the Prenatal Diagnosis and Treatment of an Uncommon Tumor

Kolen, E.R.; Horvai, Andrew E.; Perry, Victor L.; Gupta, Nalin

doi:10.1159/000070808

Cited by 8 publications

(2 citation statements)

References 23 publications

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“…We found, however, that due to its better contrast resolution, MR imaging was more sensitive than US for the detection of this heterogeneity. The rapid growth of these tumors and their propensity to contain necrotic parts probably explain this observation [12]. An additional factor is that these tumors contain tissue from the three different germ cell layers.…”

Section: Imagingmentioning

confidence: 95%

Fetal intracranial tumors: a review of 27 cases

et al. 2008

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Fetal intracranial tumors are rare. The diagnosis is generally made on histology after birth. The aim of this study was to analyze clinical and imaging data in a series of fetal intracranial tumors and emphasize the findings that may help approach the diagnosis antenatally. We retrospectively analyzed imaging and clinical findings in 27 cases of fetal intracranial tumors assessed by ultrasound (27/27) and MR imaging (24/27). A histological diagnosis was always obtained. Main diagnoses included 15 germinal tumors (13 teratomas), 4 glial tumors, 2 craniopharyngiomas and 3 hamartomas. Average gestational age at diagnosis was 27 weeks for teratomas, 21 weeks for hamartomas and 34 weeks for glial tumors. All tumors but one were supra tentorial, and the lesion extended in the posterior fossa in two teratomas. A heterogeneous pattern, which was more frequently seen in teratomas, was better visualized by MR than US imaging. In addition, in two cases of teratomas, MR imaging better assessed the extension of the tumor. Teratomas and gliomas are the most frequent brain tumors in the fetus. US and MR imagings appear complementary in the prenatal assessment of these lesions.

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Section: Imagingmentioning

confidence: 95%

Fetal intracranial tumors: a review of 27 cases

et al. 2008

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“…A bimodal age distribution of ACP is observed, with peaks in children aged 5-15 years and adults 45-60 years [1]. They are often difficult to excise surgically, and they have a 10% to 40% recurrence rate [2]. There are at two types of craniopharyngioma: Adamantinomatous craniopharyngioma (ACP) and papillary craniopharyngioma (PCP).…”

Section: Introductionmentioning

confidence: 99%

Differential Expression of Immunohistochemistry Markers for Epithelial/Squamous Cells in Adamantinomatous Craniopharyngioma

Abu-Farsakh¹

2017

ICPJL

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Context: Adamantinomatous cranio pharyngioma (ACP) is an epithelial neoplasm that is located in the sellar regions. It has at least four different squamous histological areas: superficial mature squamous (SMS), stellate reticulum (SR), palisaded basal columnar (PBC) cells and the wet keratin (WK).Design: Twenty two cases of ACP were reviewed from our archives from the period 2005-2012. Immunostainings for cytokeratin 7, cytokeratin 20, cytokeratin 19. high molecular weight cytokeratin (HMWC), low molecular weight cytokeratin (LMWC), epithelial membrane antigens (EMA), cytokeraitn 5/6 and p63 were performed. In addition, immunostainings for p16, p53, Ki-67 and B-catenin were performed.Results: HMWC was positive in all 22 cases in all squamous parts. Cytokeratin 19 was positive in PBC and SR but negative in SMS and WK parts. Cytokeratin 20 was negative in all squamous parts. EMA was positive in SR and WK, but negative in PBC and SMS in 17/22 cases. p63 was positive in PBC and SR cells, but negative in WK and SMS s in 16/22 cases. p16 was positive in PBC and SR in 15/22 cases. Twelve cases show positive p53 immunostainings with range 2%-50% of the cells. Ki67 showed more than 10% positivity in 13 cases, and low positivity or negative in 12 cases. B-catenin was positive in PBC in 11 cases in cytoplasmic and nuclear pattern and was positive in 11 cases in cytoplasmic pattern only.Conclusions: ACP has distinctive patterns of immunostainings for different epithelial and squamous markers. This knowledge helps in diagnosing ACP even in small biopsies and can help to differentiate it from its mimickers.

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