Congenital Cytomegalovirus Infection and Diabetes

Antenatal risk factors for childhood diabetes mellitus; a case-control study of medical record data in Yorkshire, UK

“…The role of viruses was suggested following the observation of increased risk of IDDM in congenital rubella syndrome [10] and congenital cytomegalovirus infection [11]. More recently, fetal exposure to enteroviruses has been associated with Diabetologia (1997) 40: 933-939 Antenatal risk factors for childhood diabetes mellitus; a case-control study of medical record data in Yorkshire, UK Summary Environmental risk factors for childhood insulin-dependent diabetes mellitus (IDDM) have been investigated using data abstracted from the obstetric records of mothers participating in a population-based case-control study of children (0-15 years) diagnosed with IDDM during 1993-1994.…”

Congenital rubella: citation virus or viral cause of type 1 diabetes?

“…It should, however, be noted that the association between rubella and diabetes might never have come to light if the children had not presented in large numbers at around the same time, and had not required institutional support for easily identifiable afflictions such as deafness and blindness. In all events, this search revealed no further evidence of a link to intrauterine exposure to mumps, and the link to congenital cytomegalovirus is equally tenuous; there is a single report in the literature of a boy who presented with diabetic ketoacidosis at 13 months of age [42]. A Swedish survey compared 76 affected children with 19,483 unaffected children born during the same period; diabetes developed in one of the children with cytomegalovirus and in 38 of the healthy children.…”

Islet Endothelium: Role in Type 1 Diabetes and in Coxsackievirus Infections

“…Rubella virus (Karvonen et al, 1993), mumps virus (Hyoty et al, 1988, cytomegalovirus (Ward et a., 1979), rotavirus (Honeyman et al, 2000) and enteroviruses (EV) (Lonnrot et al, 2000;Stene et al, 2010) have all been suggested as environmental factors contributing to type 1 diabetes. EV, especially those of the Coxsackievirus B (CVB) group (Hyöty et al, 1988;Varela-Calvino & Peakman , 2003;Green et al, 2004), are historically the prime suspects as important aetiological determinants and seroepidemiological, histopathological, animal studies, and in vitro experiments have provided the strongest overall evidence for these viruses.…”