Congenital cytomegalovirus infection inducing non-congenital sensorineural hearing loss during childhood; a systematic review

Riga, Maria; Korres, George; Chouridis, Pantelis; Naxakis, S; Danielides, Vassilios

doi:10.1016/j.ijporl.2018.10.005

Cited by 35 publications

(26 citation statements)

References 54 publications

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“…In our study, we focused on outcomes within the first/second year of life, the most critical periods for the child neurodevelopment. Aware of the possibility of late-onset SNHL [16,17], it would be interesting to analyze, in further works, how many of these children have a need for belated hearing aid repair.…”

Section: Discussionmentioning

confidence: 99%

Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection

et al. 2020

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Cytomegalovirus (CMV) is the leading cause of congenital infection. Its occurrence is phenotypically heterogeneous. The type of maternal infection, primary or non-primary, is an important factor related to the symptomatic disease, the primary infection was long considered the only cause of severe neonatal disease. We aimed to analyze the association of primary and non-primary infection with pathological outcomes in infants and with long-term sequelae at follow-up. This was a monocentric retrospective observational study on a population of 91 infants diagnosed with a CMV infection at the Neonatal Care Unit of Neonatology at the Sant’Anna Hospital of Turin during the period of June 2005 to December 2018. Infants underwent clinical, laboratory, and neuroradiological evaluations at birth. Subsequently, the patients were monitored in an auxological, neurodevelopment, and audiological follow-up. Regarding primary vs. non-primary infection, we found a higher percentage of incidence of symptomatic and neurological localized infection, as well as long-term sequelae in the latter. However, no significant difference between the two populations was found. We underline the possibility of re-infection in previously immunized mothers (non-primary infection) with unfavorable neonatal and long-term outcomes.

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Section: Discussionmentioning

confidence: 99%

Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection

et al. 2020

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“…However, CMV still remains an unfortunate burden when untreated or in its asymptomatic form: it has a high incidence, occurring in 0.2-0.5% of live births, of whom 10% will go on to develop hearing loss, accounting overall for a quarter of childhood deafness cases (Usami et al, 2017). The virus causes a wide variety of hearing loss phenotypes, which may be profound, asymmetric, and, in some cases, progressive with a delayed onset which may occur up to 16 years of age (Riga et al, 2018). As may be expected, there is debate regarding the underlying pathology, with an understandably limited amount of postmortem tissue available for examination; there is evidence of damage to the stria vascularis and…”

Section: Virusesmentioning

confidence: 99%

The use of animal models to study cell transplantation in neuropathic hearing loss

Abbas

Rivolta

2019

Hearing Research

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Auditory neuropathy (AN) is a form of sensorineural deafness specifically affecting the conduction of the nerve impulse from the cochlear hair cells to the auditory centres of the brain. As such, the condition is a potential clinical target for 'cell replacement therapy', in which a functioning auditory nerve is regenerated by transplanting an appropriated neural progenitor. In this review, we survey the current literature and examine possible experimental models for this condition, with particular reference to their compatibility as suitable hosts for transplantation. The use of exogenous neurotoxic agents such as ouabain or β-bungarotoxin is discussed, as are ageing and noise-induced synaptopathy models. Lesioning of the nerve by mechanical damage during surgery and the neuropathy resulting from infectious diseases may be very relevant clinically, and we discuss whether there are good models for these situations. We also address genetic models for AN, examining whether the phenotypes truly model the clinical situation in their human counterpart syndromes-we use the example of the hyperbilirubinaemic Gunn rat as a particular instance in this regard.

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“…The prevalence of hearing loss is 30% to 65% in symptomatic neonates and 7%–15% in asymptomatic neonates. 4 5 6 7 Congenital CMV infection is the most common non-genetic cause of congenital sensorineural hearing loss (SNHL). 8 Timely diagnosis and intervention are essential for children with SNHL to prevent delayed language development; thus, universal newborn hearing screening (NHS) programs have been implemented in many countries (including Korea) to identify children at high risk for congenital SNHL.…”

Section: Introductionmentioning

confidence: 99%

Audiologic Status of Children with Confirmed Cytomegalovirus Infection: a Case Series

et al. 2020

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Background: Congenital cytomegalovirus (CMV) infection is the most common non-genetic cause of sensorineural hearing loss (SHNL) in children. Only about 10% to 15% of children with congenital CMV are symptomatic, and most are not diagnosed at birth. About 7% to 15% of clinically asymptomatic patients may develop later complications, including SNHL, which is the most common sequela in clinically asymptomatic patients. In this study, hearing status was investigated in children with confirmed CMV infection and neonatal hearing screening (NHS) histories were reviewed to explore hearing loss caused by CMV. Methods: The medical records of 58 children who were diagnosed with confirmed CMV infection were reviewed for clinical symptoms and signs of CMV infection. Hearing status was evaluated with age-appropriate audiological test batteries. Results: A total of 58 children (M:F = 32:26 patients; age at study: mean, 5.62 years, range, 1-10 years) were diagnosed serologically with CMV infection (14 patients, 21.1%), or diagnosed via PCR of serum (5, 7.9%) and/or PCR from urine (19, 26.8%). Hearing loss was confirmed in 11 children (19.0%), being bilateral in 6 (54.5%), and unilateral in 5 (45.5%). Note that 7 of 17 ears with hearing loss passed NHS and were diagnosed only after reevaluation when CMV infection was identified. Conclusion: Hearing loss is a serious complication of CMV infection in children. Our results highlight the importance of timely audiological evaluation in children with clinically symptomatic CMV infection even if they pass NHS.

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Congenital cytomegalovirus infection inducing non-congenital sensorineural hearing loss during childhood; a systematic review

Cited by 35 publications

References 54 publications

Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection

Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection

The use of animal models to study cell transplantation in neuropathic hearing loss

Audiologic Status of Children with Confirmed Cytomegalovirus Infection: a Case Series

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