Congenital cytomegalovirus infections

Malm, Gunilla; Engman, Mona-Lisa

doi:10.1016/j.siny.2007.01.012

Cited by 150 publications

(134 citation statements)

References 40 publications

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“…The prevalence of congenital HCMV infection in newborn babies is 0.5-2.2%. [39][40] Some of these individuals may develop HCMV tolerance. Tolerance may also in theory develop during early transmission of the virus to nursing infants.…”

Section: E982391-4 Volume 4 Issue 2 Oncoimmunologymentioning

confidence: 99%

Discordant humoral and cellular immune responses toCytomegalovirus(CMV) in glioblastoma patients whose tumors are positive for CMV

et al. 2015

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Submit your article to this journal Background. Glioblastoma (GBM) is the most common malignant brain tumor in adults and is nearly always fatal. Emerging evidence suggests that human Cytomegalovirus (HCMV) is present in 90-100% of GBMs and that add-on antiviral treatment for HCMV show promise to improve survival.Methods. In a randomized, placebo-controlled trial of valganciclovir in 42 GBM patients, blood samples were collected for analyses of HCMV DNA, RNA, reactivity against HCMV peptides, IgG, and IgM at baseline and at 3, 12, and 24 weeks of treatment.Results. All 42 tumors were positive for HCMV protein. All patients examined had at least one blood sample positive for HCMV DNA, 63% were HCMV RNA positive, and 21% were IgM positive. However, 29% of GBM patients were IgG negative for HCMV. Five of these samples were positive in an enzyme-linked immunosorbent assay (ELISA) that used antigens derived from a clinical isolate. Blood T cells from 11 of 13 (85%) HCMV IgG-negative GBM patients reacted against HCMV peptides. Valganciclovir did not affect IgG titers, DNA, or RNA levels of the HCMV immediate early (HCMV IE) gene in blood.Conclusion. In GBM patients, HCMV activity is higher than in healthy controls and serology is a poor test to define previous or active HCMV infection in these patients.

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Section: E982391-4 Volume 4 Issue 2 Oncoimmunologymentioning

confidence: 99%

Discordant humoral and cellular immune responses toCytomegalovirus(CMV) in glioblastoma patients whose tumors are positive for CMV

et al. 2015

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“…The prevalence of infection increases with age, and is higher for those with a lower socioeconomic status, and people living in developing countries. Congenital CMV infection occurs in approximately 0.2 to 2.4% of all live births [5][6][7]. Perinatal infection occurs more frequently than congenital infection and thus many more are infected within the first year.…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus Infection in Infantile Hepatitis

2012

Pediatr Gastroenterol Hepatol Nutr

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“…[10][11][12] Of these babies 10 to 15% are acutely symptomatic at birth, and among these infants up to 80% will have serious sequelae. 2,3 Clinical presentation of cCMV can involve all systems that are commonly explained by the spread of CMV virus during fetal viremia and subsequent T-cell response to CMV antigens expressed on the interstitial cells of different organs (liver, brain, lungs, etc.). 13,14 In contrast, acquired CMV infection (through contamination during delivery or via breast feeding after delivery) rarely causes harmful sequelae.…”

Section: Discussionmentioning

confidence: 99%

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2016

AJP Rep

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The mother of our patients was an asymptomatic 22-year-old gravida 5, para 2 woman with two previous term vaginal deliveries and two miscarriages at 12 and 13 weeks. She had a spontaneous dichorionic pregnancy with inconsistent prenatal care, marijuana use in the first trimester, and smoking throughout the entire pregnancy. Her prenatal screening showed normal serology, and she denied any history of viral infection during pregnancy. Her first prenatal ultrasound was done at 26 weeks of postmenstrual age and revealed twin A (male) to be small for gestational age with an estimated fetal weight in the 5th percentile and head circumference below the 3rd percentile. Twin B (female) was appropriate for gestational age. Repeated ultrasound at 30 weeks of gestational age showed that twin A continue to have intrauterine AbstractBackground Cytomegalovirus (CMV) is one of the most common causes of serious viral intrauterine infections. It is universally distributed among the human population with an average incidence of 0.15 to 2%. Indeed, at least half of the women in the reproductive age have evidence of prior CMV infection. Epidemiology and Pathogenicity However, it is not a usual practice to screen asymptomatic pregnant woman or neonates for CMV. Even if a mother developed a primary CMV infection during pregnancy, up to 90% of the newborns with congenital CMV will be asymptomatic at the time of birth. Only 5 to 7% of the infected babies will be acutely symptomatic, and the typical clinical presentation includes intrauterine growth restriction, microcephaly, various cutaneous manifestations (including petechiae and purpura), hematological abnormalities (particularly resistant thrombocytopenia), hepatosplenomegaly, chorioretinitis, hepatitis, etc. In contrast, acquired CMV infection is extremely unlikely to cause any serious sequelae for the infant. Cases We present a case of congenital and acquired CMV infection in twins with a focus of dissimilarity in presentation, clinical course, and outcome.

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Congenital cytomegalovirus infections

Cited by 150 publications

References 40 publications

Discordant humoral and cellular immune responses toCytomegalovirus(CMV) in glioblastoma patients whose tumors are positive for CMV

Discordant humoral and cellular immune responses toCytomegalovirus(CMV) in glioblastoma patients whose tumors are positive for CMV

Cytomegalovirus Infection in Infantile Hepatitis

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