Congenital Deformities and Herbal " Slimming Tablets "

Cullis, Jeremy

doi:10.1016/s0140-6736(62)90387-2

Cited by 24 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lack of teratogenicity demonstrated in this case is of particular interest, since teniposide has been shown to be embryotoxic and teratogenic in mice but only at doses considerably higher than those required to produce antitumor effects [21]. Compounds containing crude podophyllin have been reported to have exerted fetotoxic effects when administered orally in the first trimester [22] or topically in the third trimester [23] of pregnancy.…”

Section: Discussionmentioning

confidence: 84%

Normal infant after combination chemotherapy including teniposide for Burkitt's lymphoma in pregnancy

Lowenthal

et al. 1982

Med. Pediatr. Oncol.

View full text Add to dashboard Cite

A 32-year-old woman was treated for Burkitt's lymphoma diagnosed during the 22nd week of pregnancy. Chemotherapy consisting of doxorubicin (Adriamycin), vincristine, teniposide (VM-26), cyclophosphamide, and prednisolone (AVTEP) was given each 2.5 to 3 weeks from the time of the diagnosis until delivery in the 37th week. Bleomycin and intrathecal methotrexate were also given from the 35th week.The infant was born after an assisted vaginal delivery and was fully developed and normal in all respects. This paper confirms prior reports that cytotoxic chemotherapy may safely be given during the second and third trimesters of pregnancy without adverse effects on the fetus. To our knowledge it is the first report of the use of teniposide, a new podophyllin derivative, during pregnancy. We report the results of the use of cytotoxic chemotherapy during the second and third trimesters in a pregnant woman with nonendemic Burkitt's lymphoma. In total, seven drugs were given including teniposide, a newly introduced podophyllin derivative, doxorubicin, and intrathecal methotrexate. CASE REPORTA previously healthy 32-year-old trained nurse presented in the 22nd week of her third pregnancy with a 12 cm mass in the left axilla. Examination disclosed a similar mass, of 8 cm in diameter, abutting the uterine fundus. No other masses were detected either clinically or on chest X ray or computerized tomographic scan of the abdomen.Full blood counts, biochemical profile, and bilateral trephine bone marrow biopsies were normal. Biopsy of the axillary mass was initially interpreted as showing diffuse histiocytic lymphoma [9]. However, on review it was clear that the features of Burkitt's lymphoma were present [lo-111. On low power the tumor was cellular with a diffuse pattern and a marked "starry sky" appearance. The high power view is shown in Figure 1. In addition to the details illustrated, the Unna-Pappenheim stain showed intense pyroninophilia within the cytoplasm of virtually all the tumor cells. Small numbers of cytoplasmic vacuoles were also evident [ 12).After full discussion with the patient, she was treated with the combination of doxorubicin (Adriamycin), vincristine, teniposide, cyclophosphamide (Endoxan), and prednisolone (AVTEP). The doses given were doxorubicin, 35 mg/m* intravenously (IV) Day 1; vincristine, 2 mg IV Day 1; teniposide, 75 mg/mz IV Day 1; cyclophosphamide, 400 mg/m2 IV Day 1; and prednisolone, 100 mg orally Days 2-5 inclusive. Doses of doxorubicin, teniposide, and cyclophosphamide were escalated after the second course to 50, 100, and 750 mg/m2, respectively. Courses were given each 2.5 or 3 weeks depending on hematological recovery. Six courses were given from the time of diagnosis to the day of delivery inclusive.The AVTEP combination was commenced on the basis of the initial diagnosis of diffuse histiocytic lymphoma; its value is being assessed as part of the Australia-New Zealand non-Hodgkin's lymphoma study [13]. Although not a standard treatment for Burkitt's lymphoma, it was continued after patho...

show abstract

Section: Discussionmentioning

confidence: 84%

Normal infant after combination chemotherapy including teniposide for Burkitt's lymphoma in pregnancy

Lowenthal

et al. 1982

Med. Pediatr. Oncol.

View full text Add to dashboard Cite

show abstract

“…Experimental studies in animals have clearly demonstrated that podophyllin is embryotoxic and has a strong growth retarding effect on pregnancy [36] [37]. Fetal anomalies suspected to have been induced by podophyllin include preauricular skin tags, limb malformations, simian crease, septal heart defects and polyneuritis [38] [39]. Intrauterine death has also followed the application of podophyllin on vulvarwarts [40].…”

Section: Discussionmentioning

confidence: 99%

“…Sundharam in 2011 put precautions based on the recommendations of Fisher [42], Miller [43] and others [38]- [40], so the following precautions are considered obligatory in this table:…”

Section: Discussionmentioning

confidence: 99%

Genital Warts in Infants and Children <br>—Re-Evaluation of Podophylline 15% as an Effective Topical Therapy

Sharquie¹,

Noaimi²,

Almallah³

2014

JCDSA

View full text Add to dashboard Cite

Background: Condylomataacuminata is an infection caused by Human Papilloma Virus, rarely reported in infants and children. Podophylline as a treatment for this condition has been used cautiously in this age group. Objective: To report the cases of anogenital warts including condy lomataacuminata in infants and children and to evaluate the effectiveness and side effects of 15% podophyllin in treatment of genital warts. Patient and Methods: Thirty infants and young children were seen in Department of Dermatology and Venereology-Baghdad Teaching Hospital in this case descriptive and therapeutic trial, in the period from January 2011 to August 2012. Their ages ranged from 8-72 (30.43 ± 15.85) months, 20 females and 10 males with a female:male ratio of 2:1. The duration of the disease ranged from 1-12 (5.26 ± 4.00) months. All demographics data were recorded in this study. History and examination were carried out to all patients. Family members including mothers were assessed about the presence of any type of viral warts in other location of body. Podophyllin (15%) in tincture benzoin was applied once weekly to all viral warts and the parents advised to wash out after 2 hours of application. The number of applications was repeated until full recovery. Follow-up after recovery was carried out for 6 months to watch for any relapse and to record local or systemic side effects. Results: The clinical pictures were mostly acondylomata acuminata in a form of cauliflower like warts in 20 (73.33%) patients, while in 10 (26.77%) patients there were ordinary verruca vulgaris like warts. The location of warts was perianal in 23 (76.66%) patients, genital only in 2 (6.66%) patients, and mixed in 5 (16.66%) patients. Topical applications of podophyllin 15% gave a full recovery in 27 (90%) patients, while in 3 (10%) patients there was partial response. The number of applications ranged from 1-4 (2.7 ± 1.42) applications. Follow up for 6 months after recovery showed relapse in only one patient, and no side effects were reported in any patients. Conclusion: There is upsurge of cases of anogenital warts among infants and children. Podophyllin (15%) in tincture benzoin is an effective therapy and no local or systemic side effects were recorded in any case.

show abstract

“…A 1962 report described a 24‐year‐old female who consumed ‘slimming tablets’ that contained podophyllin and other extracts from 5th through 9th week of gestation. She gave birth to term female infant with multiple anomalies including septal heart defect, supernumerary left thumb, right external ear defect, and absent right radius and thumb . Another report was of 18‐year‐old woman at 34 weeks gestation who used 1.88 g of podophyllin on vulvar warts which were friable and bleeding easily.…”

Section: Antiviralmentioning

confidence: 99%

“…She gave birth to term female infant with multiple anomalies including septal heart defect, supernumerary left thumb, right external ear defect, and absent right radius and thumb. 29 Another report was of 18-yearold woman at 34 weeks gestation who used 1.88 g of podophyllin on vulvar warts which were friable and bleeding easily. Two days later, foetal heart sounds were lost and a stillborn foetus was delivered 10 days later.…”

Section: Imiquimod (Category C)mentioning

confidence: 99%

Topical antiviral and antifungal medications in pregnancy: a review of safety profiles

Patel

Schwartz

Lambert

2017

Acad Dermatol Venereol

View full text Add to dashboard Cite

Medications should be employed with caution in women of childbearing age who are pregnant or considering pregnancy. Compared to oral or parenteral agents, topical medications have limited systemic absorption and are deemed safer. However, their safety profile must be assessed cautiously due to the limited available data. In this article, we aggregate human and animal studies to provide recommendations on utilizing topical antiviral and antifungal medications in pregnancy. For antiviral medications, acyclovir and trichloroacetic acid are safe to use in pregnancy. Docosanol, imiquimod and penciclovir are likely safe, but should be utilized as second-line agents. Podofilox and podophyllin resin should be avoided. For antifungal medications, clotrimazole, miconazole and nystatin are considered first-line agents. Butenafine, ciclopirox, naftifine, oxiconazole and terbinafine may be utilized after the above agents. Econazole should be avoided during the first trimester and used sparingly during 2nd and 3rd trimester. Ketoconazole and selenium sulphide are likely safe, but should be employed in limited areas for brief periods.

show abstract

Congenital Deformities and Herbal " Slimming Tablets "

Cited by 24 publications

References 9 publications

Normal infant after combination chemotherapy including teniposide for Burkitt's lymphoma in pregnancy

Normal infant after combination chemotherapy including teniposide for Burkitt's lymphoma in pregnancy

Genital Warts in Infants and Children <br>—Re-Evaluation of Podophylline 15% as an Effective Topical Therapy

Topical antiviral and antifungal medications in pregnancy: a review of safety profiles

Contact Info

Product

Resources

About

Congenital Deformities and Herbal " Slimming Tablets "

Cited by 24 publications

References 9 publications

Normal infant after combination chemotherapy including teniposide for Burkitt's lymphoma in pregnancy

Normal infant after combination chemotherapy including teniposide for Burkitt's lymphoma in pregnancy

Genital Warts in Infants and Children &lt;br&gt;—Re-Evaluation of Podophylline 15% as an Effective Topical Therapy

Topical antiviral and antifungal medications in pregnancy: a review of safety profiles

Contact Info

Product

Resources

About

Genital Warts in Infants and Children <br>—Re-Evaluation of Podophylline 15% as an Effective Topical Therapy