Congenital diaphragmatic hernia: the prognostic significance of the site of the stomach

Goodfellow, T.; Hyde, I.; Burge, D.M.; Freeman, N.V.

doi:10.1259/0007-1285-60-718-993

Cited by 33 publications

(16 citation statements)

References 3 publications

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“…Our study confirmed the pejorative significance of some predictors previously described in the literature, such as the early diagnosis, the presence of the stomach in the thorax and the existence of associated malformations [4±9, 19,20,27,28]. Actually, all survivors were diagnosed after 25 weeks of gestation.…”

Section: Discussionsupporting

confidence: 89%

Congenital diaphragmatic hernia: antenatal prognostic factors

et al. 1997

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Our study confirmed the factors for a poor prognosis associated with CDH previously described in the literature, but none with a consistent demonstration of accuracy. LV hypoplasia may be a more accurate predictor of outcome and of PH but it has to be assessed by prospective studies with larger samples. Further basic science and Doppler-flow studies may be helpful to understand the natural history and pathophysiology of LV hypoplasia in CDH.

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Section: Discussionsupporting

confidence: 89%

Congenital diaphragmatic hernia: antenatal prognostic factors

et al. 1997

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“…Goodfellow et al [15] examined retro spectively the plain radiographs of the chest and abdomen of 50 neonates with CDH and found that 20 of 34 (59%) with an intrathoracic position of the stomach died, whereas 15 of 16 infants (94%) where this was not the case survived. In our study the stomach was in the thorax in all the fetuses.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of Congenital Diaphragmatic Hernia: Associated Malformations and Chromosomal Defects

Thorpe-Beeston

Gosden²,

Nicolaides³

1989

Fetal Diagn Ther

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In 36 fetuses with congenital diaphragmatic hernia (CDH) diagnosed at 18–36 weeks’ gestation, detailed ultrasound examination was performed for the detection of associated malformations and assessment of the likelihood of pulmonary hypoplasia. In all cases karyotyping was undertaken in blood samples obtained by cordocentesis. In 11 (31 %) fetuses there were lethal chromosomal abnormalities and in 6 (17 %) of the chromosomally normal fetuses there were additional lethal malformations. Of the 17 fetuses with isolated CDH and where the pregnancy was not electively terminated. 9 (60%) survived and 6 (40%) died in the neonatal period due to pulmonary hypoplasia. The presence or absence of polyhydramnios, fetal breathing movements, mediastinal shift and thoracic position of the stomach were not useful in predicting postnatal outcome.

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“…Several attempts have been made to identify some useful predictors of outcome; however, these markers fail to predict exactly whether a fetus with CDH will survive. In previous studies, some prenatal parameters have been related to the neonatal prognosis, including (1) polyhydramnios, 1 (2) the presence of an intrathoracic stomach 16,27,28 or liver, 19,29,30 (3) the lung-thorax transverse area ratio (LTR), 18,31 (4) the lung-to-head ratio, 32 and (5) fetal breathing movement. 20,21,33 In the past decade, fetal hemodynamic changes have been evaluated with Doppler fl owmetry, such as Doppler fl ow measurement of velocity in the pulmonary artery 22,34 and color fl ow mapping in the mesenteric artery, 23 umbilical vein, and venous duct.…”

Section: Discussionmentioning

confidence: 99%