Congenital factor VII deficiency

Mandhyan, R; Tiwari, Alankar; Cherian, G

doi:10.1093/bja/aep389

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…The activation of Factor VII initiates a series of extracellular coagulation events. [11,12] A defect such as Factor VII deficiency could occur with mild-to-moderate severity and may present itself with a minor prolongation in the PT. If physicians do not run certain coagulation factor tests to further investigation of isolated PT prolongation, they may not diagnose the condition accurately.…”

Section: Discussionmentioning

confidence: 99%

Factor VII Deficiency in Systemic Primary Amyloidosis: A Rare Case

Dursun

Akyar

Uygun

et al. 2018

CRIM

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Introduction: Isolated and combined factor deficiencies are known to occur in systemic primary amyloidosis. The most common factor deficiency known in these cases is isolated factor X deficiency. Other factor deficiencies are relatively less frequent. Isolated factor VII deficiency occurs very rarely in cases of systemic primary amyloidosis. Case report: A 58-year-old male patient previously presenting to another health center with complaints of generalized edema, fatigue, and itching had proteinuria and then he was diagnosed with systemic primary amyloidosis after the renal biopsy for proteinuria etiology. The patient's laboratory tests showed prolongation of prothrombin time and factor VII deficiency. The patient responded well to the treatment for primary amyloidosis and factor VII deficiency. Discussion: In cases of systemic primary amyloidosis, if the etiology of prolonged prothrombin time involves no liver disease, warfarin use, or malabsorption, physicians should always keep in mind rare factor deficiencies such as factor VII deficiency, along with common factor deficiencies.

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Section: Discussionmentioning

confidence: 99%

Factor VII Deficiency in Systemic Primary Amyloidosis: A Rare Case

Dursun

Akyar

Uygun

et al. 2018

CRIM

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“…The functions of antithrombin and other serpins in the modulation of thrombin activity are discussed in Chapter 7. [120][121][122] There is also evidence of ethnic clustering. It should be noted that the effort to develop a specific inhibitor of thrombin for therapeutic use is not new and can be traced back at least to the work of Markwardt and others on hirudin.…”

Section: Vitamin K-dependent Proteinsmentioning

confidence: 99%