Congenital Generalized Follicular Hamartoma Associated With Alopecia and Cystic Fibrosis in Three Siblings

Familial Multiple Basaloid Follicular Hamartomas: A Report of Two Affected Sisters

“…In addition to the typical solitary and multiple forms of BFH described here, the histologic findings of BFH have been reported in several other clinical settings: generalized lesions in association with alopecia and myasthenia gravis (8,9), cystic fibrosis (10), or systemic lupus erythematosus (11), and linear and unilateral variants (4,12–14). The relevance of BFH in these cases to the entity of familial multiple BFH, as described in our patients and by Brownstein (1), is unknown.…”

Basaloid Follicular Hamartoma: A Cautionary Tale and Review of the Literature

“…The most notable difference between FBP and BFH is in regard to the presence or absence of keratin cysts. Leshin and White report no keratin cysts in lesions of FBP, 7,30 whereas keratin cysts are seen in lesions of BFH and infundibulocystic BCC. Additionally, Leshin and White report no direct epidermal attachment for FBP, whereas there are clear epidermal attachments in BFH and infundibulocystic BCC 7 …”

“…Both BCC and BFH are discrete, superficially based basaloid epithelial proliferations that may be multifocal 5,6,14,19 . BFH is a vertically oriented neoplasm that is commonly folliculocentric 25,30 . On histologic exam, the silhouette of BFH has discrete epithelial proliferations consisting of both anastomosing squamoid (90%) and basaloid (10%) columns or cords with occasional horn cysts 1,2,8,10,11,14,18,24,26,34,35 .…”

Ichthyosis follicularis with alopecia and photophobia (IFAP): late diagnosis in 18‐year‐old man

“…This syndrome has been confused in the literature with other conditions in which alopecia and follicular changes are the main features 13,21–23 . In addition, there is new alopecia–contractures–dwarfism mental retardation (ACD) syndrome, which shares a unique combination of features with IFAP syndrome, and it may be that some of reported patients having IFAP may also have ACD syndrome 24 …”