Congenital glioblastoma

Singhal, Ritu; Jain, Manish; Tanwar, Rajendra Kumar; Raman, Natasha

doi:10.1007/bf02751992

Cited by 12 publications

(6 citation statements)

References 11 publications

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“…The number of patients included in each reviewed paper ranged from a single patient in a case report to 250 patients in a literature review 24,25 . These 44 papers yielded 468 cases of intracranial tumors in children 6 months of age and less 1,3–5,8–10,12,13,15,17–19,21,26,27,29–31,33–35,37,38,40–46,51–55,57–59,61,62,65–67 . There was significant variability in brain tumor histologies (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Surgical Treatment of Brain Tumors in Infants Younger than Six Months of Age and Review of the Literature

et al. 2012

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Object Brain tumors are rare in infants under 6-months of age. These tumors can be challenging to treat surgically. We analyzed a modern series of patients treated by a multidisciplinary team at a tertiary care center and performed a literature review of this unique population. Methods Retrospective clinical data was collected for patients surgically treated for intracranial mass lesions at The Children’s Hospital of Philadelphia from 1998 to 2007. Dermoid cysts and other skull-based lesions were excluded from the analysis. Results Sixteen patients under 6-months of age underwent surgery for primary intracranial mass lesions. The median age of the patients at surgery was 5.2 months (range 1.4 to 6 months of age). Children most often presented with a bulging fontanelle, hydrocephalus, or macrocephaly (7 patients). Vomiting was seen in 5 patients, cranial nerve palsies in 1 patient, and seizures in 3 patients. All patients had tumor resections and post-operatively were monitored in the intensive care unit. The final pathology consisted of atypical teratoid/rhabdoid tumor (3 cases), primitive neuroectodermal tumor/medulloblastoma (3 cases), choroid plexus papilloma (2 cases), astrocytoma (2 cases), ganglioglioma (2 cases), desmoplastic infantile ganglioglioma (2), glioblastoma multiforme (1), and choroid plexus carcinoma (1). Two intra-operative deaths occurred. Of the surviving 14, a gross total resection was achieved in 4. Adjuvant therapy was determined by a multidisciplinary team composed of neuro-oncology, neurosurgery, and radiation oncology. Seven patients were treated with chemotherapy, 1 patient had proton beam therapy. Five-year overall survival was 45%. The eight surviving patients had neurological sequelae, and developmental outcome was variable. Conclusions Brain tumors are uncommon in children under 6-months of age. Patients present with a variety of tumor pathologies. Children who survive have neurological sequelae. More studies are necessary to understand the impact that different treatment options, tumor pathology, and tumor location have on neurological outcome.

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Section: Resultsmentioning

confidence: 99%

Surgical Treatment of Brain Tumors in Infants Younger than Six Months of Age and Review of the Literature

et al. 2012

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“…The report indicates that the patient had only minimally delayed milestones at 18 months condition. The long-term outcome for this case was not described [22]. Despite these reports, it remains unclear whether adjuvant therapy provides any additional benefits to surgical resection in cases of congenital GBM.…”

Section: Discussionmentioning

confidence: 97%

“…Similarly, Seker and Ozek [38] treated their patient with surgical resection followed by Children’s Cancer Group 9921 protocol consisting of carboplatin, etoposide, ifosfamide and vincristine with reported good clinical results. In contrast, Singhal et al [22] reported the use of postoperative radiation without chemotherapy. The patient received 4,000 cGy fractionated radiation over 5 weeks and CT imaging demonstrated a measurable response in the tumor volume.…”

Section: Discussionmentioning

confidence: 99%

Congenital Glioblastoma Multiforme: Case Report and Review of the Literature

Hou¹,

Bababeygy²,

Sarkissian³

et al. 2008

Pediatr Neurosurg

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Congenital glioblastoma multiforme is a rare primary brain tumor that has a unique biology distinct from pediatric and adult variants. In this report, we present a case of congenital glioblastoma with complicated management course. A literature review of previously reported cases is included to illustrate the epidemiology and natural history of this disease. A 9-month-old male infant developed acute lethargy, hemiparesis and unilaterally dilated pupil. Imaging studies revealed a large hemispheric tumor, resulting in significant midline shift suggestive of impending herniation. Emergent tumor cystic fluid drainage was performed at initial presentation. A frontotemporoparietal craniotomy was performed on the following day to attempt a gross total resection. Adjuvant chemotherapy consisting of oral temozolomide was administered. The patient eventually succumbed 4 months later due to aggressive tumor progression. Congenital glioblastoma should be included in the differential diagnosis of infants with large intracranial tumors. Although surgical intervention may increase survival, the overall outcome remains poor despite maximal multimodal treatment.

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“…5,6,10,12,17,18,21,[24][25][26]28,31,[33][34][35][36]41,42 From these publications, there were 29 cases of GBM that met our inclusion criteria. The patients underwent either CT scans or MRI based on the patient's age and the clinical presentation.…”

Section: Resultsmentioning

confidence: 99%

Radiological features of infantile glioblastoma and desmoplastic infantile tumors: British Columbia’s Children’s Hospital experience

Bader¹,

Heran²,

Dunham

et al. 2015

PED

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OBJECT Two of the more common infantile brain tumors, glioblastoma multiforme (GBM) and desmoplastic infantile tumors (DITs), can be difficult to distinguish on MRI. Both tumors occur in the supratentorial compartment and both have solid and cystic components. Differentiating between the 2 on MRI studies could assist the surgeon in discussions with family and child management. The authors report on their institutional experience with both tumors, focusing on radio-graphic features, especially the diffusion studies, which might be useful in distinguishing between infantile GBM and DIT. METHODS A retrospective review was undertaken of all infantile brain tumors treated at British Columbia’s Children’s Hospital between 1982 and 2012, and cases of GBM and DIT were recorded. Only cases that had imaging were included in the study. A literature review was completed to identify reported cases of infantile GBM and DIT. Only reports that described or included radiological studies (particularly MRI) of the tumors were included. Certain radiographic features of the tumors were reviewed, including location, size, consistency, pattern of enhancement, and features on MR diffusion studies. RESULTS Of 70 cases of infantile brain tumors, 2 GBM cases and 3 DIT cases (all 3 of which were desmoplastic infantile gangliogliomas [DIGs]) met the inclusion criteria. The radiological studies obtained in all 5 cases were reviewed by a neuroradiologist. All 5 patients had supratentorial tumors with cystic-solid consistency. Diffusion MRI studies showed restricted diffusion in the 2 GBM cases, but no evidence of restricted diffusion in the DIG tumors. The GBM tumors were heterogeneously enhancing, and the DIG tumors showed avid and homogeneous enhancement. The literature review revealed 29 cases of infantile GBM and 32 cases of DIG/DIT that met the inclusion criteria. The tumors were large in both groups. The tumors were cystic-solid in consistency in 10 of 30 (33%) of GBM cases and 28 of 32 (87.5%) of DIT cases. The contrast enhancement was heterogeneous in 9 of 30 (30%) GBM cases, and it was homogeneous and avid in 27 of 32 (84%) of DIT cases. Diffusion studies were recorded in 2 published infantile GBM cases, and in both of them diffusion was restricted. The authors only found 1 report that discussed DIG tumor features on MR diffusion studies, but the interpretation was difficult and unclear. CONCLUSIONS Magnetic resonance imaging, especially diffusion-weighted imaging, may be a useful aid in distinguishing between infantile GBM and DIT tumors, with infantile GBM demonstrating restricted diffusion.

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Congenital glioblastoma

Cited by 12 publications

References 11 publications

Surgical Treatment of Brain Tumors in Infants Younger than Six Months of Age and Review of the Literature

Surgical Treatment of Brain Tumors in Infants Younger than Six Months of Age and Review of the Literature

Congenital Glioblastoma Multiforme: Case Report and Review of the Literature

Radiological features of infantile glioblastoma and desmoplastic infantile tumors: British Columbia’s Children’s Hospital experience

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