CONGENITAL GLYCOGEN STORAGE DISEASE IN A SOUTH AMERICAN COATI (NASUA NASUA)

Abstract

A 14-mo-old South American coati (Nasua nasua) was submitted for necropsy to the University of Kentucky Veterinary Diagnostic Laboratory. The coati had a history of progressive neurologic signs beginning 3 mo prior to euthanasia. At necropsy, the coati was in thin body condition, but no other significant findings were evident. Histopathologic findings included moderate distension of neuronal cell bodies by finely vesiculated cytoplasm within the cerebrum, cerebellum, spinal cord, and intestinal ganglia. Hepatocytes and macrophages in the lung, spleen, and liver were similarly affected. Transmission electron microscopy showed numerous electrondense membranous cytoplasmic bodies, swirls, and vesicular profiles within neuronal lysosomes in the brain. To the authors' knowledge, this is the first report of a naturally occurring congenital glycogen storage disease in a South American coati and the family Procyonidae.

Procyonidae, Viverridae, Hyenidae, Herpestidae, Eupleridae, and Prionodontidae

“…An uncharacterized glycogen storage disease has been reported in a captive coati with progressive neurologic disease. Histologically, neurons, hepatocytes, and macrophages have distended cytoplasm containing finely granular material that ultrastructurally is composed of membranous structures within lysosomes (Chu and Loynachan, 2013).…”

Intervertebral disc herniation in two coatis (Nasua nasua) and postoperative laminectomy membrane formation

“…Viral and protozoal myelitis occur in raccoons and are possible diseases in coatis (8,15). Congenital glycogen storage disease was found in a young coati with chronic progressive neurological signs (6). Those differentials and neoplasia could be excluded considering the history, MRI, and surgical and histopathological findings.…”

Coati Bodies: Cytoplasmic Hyaline Globules in the Ganglionic Neurons of Aging Captive Coatis

“…Glycogen storage disease has been reported in a brown-nosed coati, and Niemann-Pick disease (sphingomyelin lipidosis) has been reported in a raccoon ( Procyon lotor ). 1,8 We report and characterize herein hyaline globules in the peripheral autonomic neurons and ganglia of predominantly aged captive white-nosed and brown-nosed coatis of both sexes from 13 different zoological institutions.…”