Congenital Granular Cell Tumor of the Arm

Çerman, Aslı Aksu; Sakiz, Damlanur; Solak, Sezgi Sarıkaya; Altunay, İlknur Kıvanç; Yalçın, Özben

doi:10.1097/dad.0000000000000212

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…In 285 reported cases, CGCT being a benign tumour associated with the jaw was reported along with a 10% occurrence of intraosseous cases of arm[ 4 5 ] and other extra-alveolar sites. Aetiology being unknown like in our case, the hypothesis correlating with hormonal imbalance was correlated by injecting oestrogen in the uterine cervix of newborn mice.…”

Section: Discussionmentioning

confidence: 99%

Congenital Granular Cell Tumour - Case Report and Review of Literature

Singh,

Tomar,

Roy

et al. 2023

Annals of Maxillofacial Surgery

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Rationale: Congenital orofacial swellings in neonates are mainly limited to vascular malformations and neuroectodermal benign tumours. Congenital granular cell tumour (CGCT) is a rare condition affecting neonates with a prevalence rate of 6 in 1 million. Our report provides a brief review of diagnosis and management. Patient Concern: A 4-day-old female neonate was brought in with the chief complaint of a single, lobulated mass protruding from the right side of the oral cavity. The inability to achieve lip seal and suckling resulting in feeding problems was the primary concern. Diagnosis and Treatment: Surgical excision of the lesion was carried out under general anaesthesia. Resected mass was confirmed to be a CGCT upon histopathological evaluation. Outcome: One-year follow-up showed satisfactory healing with no evidence of recurrence. Take-away Lesson: Ultrasonography and other imaging modalities help in differentiating it from vascular malformations. Simple surgical excision suffices to treat the condition.

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Section: Discussionmentioning

confidence: 99%

Congenital Granular Cell Tumour - Case Report and Review of Literature

Singh,

Tomar,

Roy

et al. 2023

Annals of Maxillofacial Surgery

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“…Only congenital GCT, "congenital epulis," that affects the oral mucosa differs pathologically from acquired cases of GCT and stains negatively for S100 indicating their nonneural origin. 17,66 Apart from suspected malignant lesions, surgical excision is the preferred treatment strategy for GCTs. 12 Careful assessment of the tumor margins during surgery is essential to avoid recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…Only congenital GCT, “congenital epulis,” that affects the oral mucosa differs pathologically from acquired cases of GCT and stains negatively for S100 indicating their nonneural origin. 17,66…”

Section: Discussionmentioning

confidence: 99%

Multifocal Cutaneous Granular Cell Tumor in Children: A Rare Entity

El‐Khalawany

Rageh

Hassab-El-Naby

2021

The American Journal of Dermatopathology

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Granular cell tumors (GCTs) are rare soft tissue tumors of Schwann cell origin that manifest as papulonodular lesions and occur mainly in adults. The diagnosis is usually confirmed by histopathology. Most of GCTs are benign, but some lesions may exhibit malignant criteria. This study is a retrospective case series including all children with histopathologically documented multiple GCTs who attended the dermatology department of the university hospitals between February 2008 and March 2021. The objective of our study was to raise awareness to this unrecognized and rare entity in such age group. The study included 9 patients (6 girls and 3 boys) with multiple GCTs. Their age ranged between 5 and 13 years. The lesions were skin-colored to light brown, firm, smooth-surfaced nodules. Most of the lesions were on the extremities, and their mean diameter was 160.5 mm 2 . None of the lesions exhibited any malignant criteria on histopathology. No extracutaneous or mucosal lesions were detected. Dermatologists should be aware of this rare condition in children because early recognition allows more conservative resection of the tumor and less invasive reconstruction of the defect. Our study highlights that multifocality does not necessarily indicate malignancy or other systemic comorbidities.

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“…The predilection site is the alveolar ridge, on which the maxilla occurs more frequently than the mandible at a ratio of 3:1 (5). However, Çerman et al recently reported a rare case in the arm (6). The size ranges from several millimeters to a few centimeters (5).…”

Section: Clinical and Pathological Characters Of Cgctmentioning

confidence: 99%

Multiple congenital granular cell tumours of the maxilla and mandible: a rare case report and review of the literature

et al. 2021

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Congenital granular cell tumour (CGCT) is a benign lesion that predominantly arises from the alveolar ridges of neonates, especially the maxilla. However, it's only 10 percent of multiple lesions in all reported cases, in which simultaneously mandibular and maxillary involvements are more extremely rare.For treatments of multiple CGCTs, few standard procedures were reported. In addition to surgical excision, which refers to a preferred method, conservative treatment is an available choice. Here, a case of multiple CGCTs using different therapeutic strategies was reported because of its rarity and innovation. A fiveday-old female newborn presented two congenital masses attached to the right mandibular and maxillary alveolar ridge. The size of the mandibular lesion causing difficulty in feeding was 3 cm in diameter and 0.5 cm in the maxilla. Based on different manifestations, surgical excision and conservative treatment were adopted respectively. The mandibular mass was excised while that in the maxilla underwent spontaneous regression. Satisfactory results were achieved for this patient. There was no evidence of recurrence after a 6-month follow-up. Microscopic examination and immunohistochemistry analysis confirmed the diagnosis and differential diagnosis of CGCT and even proposed the possibility of histogenesis from neural crest. Moreover, we reviewed the literature and summarized the characteristics to provide new ideas for the treatment of multiple CGCTs.

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Congenital Granular Cell Tumor of the Arm

Cited by 6 publications

References 12 publications

Congenital Granular Cell Tumour - Case Report and Review of Literature

Congenital Granular Cell Tumour - Case Report and Review of Literature

Multifocal Cutaneous Granular Cell Tumor in Children: A Rare Entity

Multiple congenital granular cell tumours of the maxilla and mandible: a rare case report and review of the literature

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