Congenital heart disease and neuroblastoma: just coincidence?

Holzer, Ralf; Franklin, Rodney C. G.

doi:10.1136/adc.87.1.61

Cited by 13 publications

(17 citation statements)

References 24 publications

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“…In addition, there is at least one published report of a patient with neuroblastoma and coexisting CCM in which it was thought that catecholamine release from the tumor might have contributed to death. 1 In our series, one patient had a stage 3 catecholamine-secreting neuroblastoma encroaching on the aorta, requiring pharmacologic blood pressure management and complicating management of CCM. Another patient had intractable hypertension after repair of an inguinal hernia, and a search revealed a catecholamine-secreting neuroblastoma.…”

Section: Discussionmentioning

confidence: 79%

“…In a review, about one third of the described CCM are neural crest-derived, a percentage that is virtually identical to that found in this study (5 of 14 patients, 36%). 1 We were concerned that our conclusion might have been the result of observational bias because patients with CCM undergo repeated medical evaluations, during which neuroblastoma might be more likely to be detected incidentally. Incidental neuroblastoma is most often observed as a small intra-adrenal lesion seen on scans done for evaluation of other conditions.…”

Section: Discussionmentioning

confidence: 99%

“…Other reported complications from neuroblastoma include arrhythmias and catecholamine-induced cardiomyopathy. 1 In addition, knowledge of existing cardiac anomalies such as abnormal valves is important for the patient, in terms of bacterial endocarditis prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

“…1 An association between these two conditions is biologically plausible because proper migration of neural crest cells is important for cardiogenesis, and ablation of the cardiac neural crest results in CCM in the chick embryo. 2 The aim of this study was to determine the strength of the association between CCM and neuroblastoma (NB) by examining their occurrence in a large series of patients with cancer.…”

mentioning

confidence: 99%

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Association between congenital cardiovascular malformations and neuroblastoma

George

Lipshultz

Lipsitz

et al. 2004

The Journal of Pediatrics

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Association between congenital cardiovascular malformations and neuroblastoma

George

Lipshultz

Lipsitz

et al. 2004

The Journal of Pediatrics

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“…Although it seems that the tendency of developing malignancy in patients with congenital heart defects has been well documented [2], association of osteosarcoma and tetralogy of Fallot (TOF) is rarely reported. We now present a rare association of surgically repaired TOF with osteosarcoma.…”

Section: Introductionmentioning

confidence: 99%

Tetralogy of Fallot cases: Prone to be Affected by Malignancies or just a Coincidence?

Radgoudarzi¹,

Hosseininejad²,

Aarabi³

et al. 2017

JCR

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Background: The tendency of developing malignancy in patients with congenital heart defects has been well documented. Osteosarcoma and tetralogy of Fallot (TOF) have never been so far reported to happen in a single patient. Case Report: An 8.5-year-old boy with history of repaired tetralogy of Fallot (TOF) one year back presented with refractory leg pain most frequently at nights. CT scan, bone scan and bone biopsy of the proximal part of the left fibula revealed: high grade intramedullary osteogenic sarcoma (OS) of osteochondroblastic type. Conclusion: According to latest genetic studies TOF and OS don't share any common genetic background; it would be interesting for clinicians to have in mind such tendency between TOF and OS to investigate if they share any origin genetically or developmentally?

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Congenital heart disease complexity and childhood cancer risk

Collins

Behren

Yang

et al. 2018

Birth Defects Research

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Background: Childhood cancer is increased in those with birth defects, including those with congenital heart disease (CHD). Lymphoma risk is increased in children with CHD. This study analyzes the effect of CHD and CHD severity on childhood cancer risk. Methods: We analyzed cancer risk in a population-based cohort of children with and without CHD born between 1988 and 2004 by linking data from the California Birth Defects Monitoring Program with data from the California Cancer Registry. We compared cancer risk in children with and without CHD, excluding children with chromosomal anomalies. Results: Of >3 million children in the birth cohort, 65,585 had birth defects (2%), 25,981 with CHD. Cancer occurred in 4,781 (0.15%) children, 43 (0.17%) with CHD. Cancer risk in CHD was increased (hazard ratio [HR]) 2.63, 95% CI: 1.95, 3.55). Leukemia was the most common cancer in those without CHD (1,722/4,738, 36%), central nervous system tumors were second (1,073/4,738, 23%), and lymphoma third (410/4,738, 9%). Among children with CHD, lymphoma and leukemia occurred with the same frequency (12/43, 28% for each). HR for lymphoma was 8.37 (CI: 4.71, 14.86) with CHD versus without. HR for leukemia was 2.05 (CI: 1.16, 3.61) with CHD versus without. CHD complexity was higher in lymphoma (3, interquartile range [IQR]: 2-3) than those with leukemia (1, IQR, 1-2; p < .02). Conclusion: Cancer risk is increased in children with CHD. Lymphoma risk is increased in CHD and is correlated with more complex CHD. These results suggest a shared developmental origin for CHD and lymphoma may be present.

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Congenital heart disease and neuroblastoma: just coincidence?

Cited by 13 publications

References 24 publications

Association between congenital cardiovascular malformations and neuroblastoma

Association between congenital cardiovascular malformations and neuroblastoma

Tetralogy of Fallot cases: Prone to be Affected by Malignancies or just a Coincidence?

Congenital heart disease complexity and childhood cancer risk

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