Congenital heart disease and the cost of mortality

Czosek, Richard J.; Anderson, Jeffery B.

doi:10.1136/openhrt-2016-000448

Cited by 6 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cost implication is enormous and is shared by the family, hospital and the government. The cost of procuring medication and surgical treatment is usually more than anticipated (14)(15)(16). For most cases, surgical corrections is needed.…”

Section: Discussionmentioning

confidence: 99%

Cyanotic congenital heart diseases among Nigerian children

Animasahun

Madise-Wobo

Kusimo

2017

Cardiovasc. Diagn. Ther.

View full text Add to dashboard Cite

Background: There are only few reports on cyanotic congenital heart diseases (CCHD) among Nigerian and African Children. The current report aim to provide the most recent hospital based data on the distribution of CCHD in children less than 14 years of age, the demographic characteristics and risk factors Results: There were 352 subjects with CCHD with a male to female ratio of 1.34:1. The children were age 2 days to 14 years with a mean ± SD of 38.62±44.74 months and median of 21 months. The most common type of CCHD (both isolated and multiple CCHD) was tetralogy of Fallot (TOF) followed double outlet right ventricle (DORV) and transposition of the great arteries (TGA). The most common mode of presentation was cyanosis.Conclusions: TOF was found in almost half of the subjects. Cases of DORV which have been rarely reported were more than those with TGA. Most were diagnosed late. Cyanosis was the most common mode of presentation. Clinical features are protean; thus a high index of suspicion is required to make an early diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Cyanotic congenital heart diseases among Nigerian children

Animasahun

Madise-Wobo

Kusimo

2017

Cardiovasc. Diagn. Ther.

View full text Add to dashboard Cite

show abstract

“…This has now created a new challenge, that of a growing adult population with CHD which exceeds the number of affected children born who require ongoing medical attention from repeated hospitalizations for surgical, catheter or non-surgical interventions [15]. Consequently, the morbidity and mortality-related economic burden placed on healthcare systems, as well, as patients and their families are astronomical [7,[16][17][18][19]. This economic burden underscores the urgency to identify the causes of CHD methodologies that could lead to strategies to prevent these defects in our children.…”

Section: Epidemiology Of Congenital Heart Diseasementioning

confidence: 99%

Environmental pollution and the development of congenital heart disease: A scoping review

Ngwezi¹,

Hornberger²,

Osornio-Vargas³

2018

apr

View full text Add to dashboard Cite

Introduction: Congenital heart disease (CHD) is the most common congenital anomaly in infancy affecting 1% of all live births worldwide of which the etiology in most affected children is unknown. The role of environmental pollutants from various sources is increasingly gaining attention. To explore the existing breadth of knowledge on this topic, we undertook a scoping review of studies examining the role of environmental pollution in relation to the development of CHD.Methods: We searched various databases for studies reporting CHD and exposures to chemicals using Medical Subject Headings (MeSH) and non-MeSH including criteria pollutants (e.g. CO, SO 2, NO 2 ), occupational, non-occupational, industrial chemicals and emissions reported in pollutant release and transfer registers (PRTR) from 1980 to 2018. Results:We identified 70 studies that were grouped into the categories of outdoor industrial chemical pollution; urban air pollution; occupational; and non-occupational exposures. There were no marked differences in proportions of studies in the first three categories, which ranged between 29-33%. Nonoccupational exposures accounted for 7% of the studies. Proximity to industrial facilities and hazardous waste sites was associated with CHD in a modest number of studies that used PRTR. Urban criteria pollutants were consistently associated with CHD. Maternal occupational exposures were more commonly studied compared to paternal exposures and organic solvents were associated with CHD in these studies. There were limited studies that examined non-occupational and multipollutant exposures. Conclusion:We identified associations between various chemicals and CHD, employing diverse methods of exposure assessment. Most studies examined single pollutant exposures and have demonstrated inconclusive findings. Future studies should examine multiple pollutant exposures and CHD. In addition to monitored data, exploratory studies could exploit PRTR in countries where such registers exist. Furthermore, multicenter studies that examine larger populations of affected patients could facilitate the discovery of the relationship between specific chemicals and CHD subtypes.

show abstract

“…Congenital heart disease (CHD), which manifests as a morphologically defective heart, affects about 1% of newborn babies, and remains the primary cause of non-infectious children mortality in the developed world ( Gilboa et al, 2010 ; van der Linde et al, 2011 ). While CHD mortality rates have been dramatically reduced in recent years thanks to advances in surgical practice and interventional technologies ( Gilboa et al, 2010 ; Czosek and Anderson, 2016 ), CHD patients continue to be at an increased risk of developing heart failure at a much younger age than the general population ( Gilljam et al, 2019 ). Despite early indicators of success, heart failure continues to take the lives of young children with CHD: 10% to 25% of newborns with a critical heart defect do not survive the first year, and 44% do not survive to 18 years of age ( Oster et al, 2013 ; Stout et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Multiscale cardiac imaging spanning the whole heart and its internal cellular architecture in a small animal model

Rykiel

López

Riesterer

et al. 2020

eLife

View full text Add to dashboard Cite

Cardiac pumping depends on the morphological structure of the heart, but also on its sub-cellular (ultrastructural) architecture, which enables cardiac contraction. In cases of congenital heart defects, localized ultrastructural disruptions that increase the risk of heart failure are only starting to be discovered. This is in part due to a lack of technologies that can image the three dimensional (3D) heart structure, to assess malformations; and its ultrastructure, to assess organelle disruptions. We present here a multiscale, correlative imaging procedure that achieves high-resolution images of the whole heart, using 3D micro-computed tomography (micro-CT); and its ultrastructure, using 3D scanning electron microscopy (SEM). In a small animal model (chicken embryo), we achieved uniform fixation and staining of the whole heart, without losing ultrastructural preservation on the same sample, enabling correlative multiscale imaging. Our approach enables multiscale studies in models of congenital heart disease and beyond.

show abstract

Congenital heart disease and the cost of mortality

Cited by 6 publications

References 12 publications

Cyanotic congenital heart diseases among Nigerian children

Cyanotic congenital heart diseases among Nigerian children

Environmental pollution and the development of congenital heart disease: A scoping review

Multiscale cardiac imaging spanning the whole heart and its internal cellular architecture in a small animal model

Contact Info

Product

Resources

About