2009
DOI: 10.4065/84.1.23
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Congenital Heart Disease Associated With Selective Serotonin Reuptake Inhibitor Use During Pregnancy

Abstract: OBJECTIVE:To determine the risk of congenital cardiac abnormalities associated with use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy. PATIENTS AND METHODS:We conducted a retrospective review of the medical records of all pregnant women presenting at Mayo Clinic's site in Rochester, MN, from January 1, 1993, to July 15, 2005, and identified 25,214 deliveries. A total of 808 mothers were treated with SSRIs at some point during their pregnancy. We reviewed the medical records of the newbor… Show more

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Cited by 147 publications
(100 citation statements)
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“…4 In 2005, based on early results of two epidemiologic studies, the US Food and Drug Administration (FDA) warned healthcare professionals that early prenatal exposure to paroxetine may increase the risk of congenital cardiac malformations and reclassified it to pregnancy category D. 5 Most malformations in the early reports leading to the FDA warning were septal defects. Since then, several studies have evaluated the teratogenicity of SSRIs and other antidepressants [6][7][8][9][10][11][12][13][14][15][16][17][18][19] , but considerable controversy remains as to whether this is a "serious concern or much ado about little" as noted in an editorial published with two of the reports. 13,1420 Existing studies have reported different associations, often in the context of multiple comparisons.…”
Section: Conclusion-resultsmentioning
confidence: 99%
“…4 In 2005, based on early results of two epidemiologic studies, the US Food and Drug Administration (FDA) warned healthcare professionals that early prenatal exposure to paroxetine may increase the risk of congenital cardiac malformations and reclassified it to pregnancy category D. 5 Most malformations in the early reports leading to the FDA warning were septal defects. Since then, several studies have evaluated the teratogenicity of SSRIs and other antidepressants [6][7][8][9][10][11][12][13][14][15][16][17][18][19] , but considerable controversy remains as to whether this is a "serious concern or much ado about little" as noted in an editorial published with two of the reports. 13,1420 Existing studies have reported different associations, often in the context of multiple comparisons.…”
Section: Conclusion-resultsmentioning
confidence: 99%
“…7,8 Based on a review of additional studies with conflicting findings (2 studies reported an increase in risk, whereas 3 did not), the FDA concluded in 2011 that it was premature to reach any conclusion about a possible link between SSRI use in pregnancy and PPHN and updated the advisory accordingly. [9][10][11][12][13] The negative studies tended to be small, raising the possibility that they had insufficient power to detect an increased risk. 10,11 Given the ongoing controversy regarding the association between SSRI exposure in late pregnancy and the risk of this highly morbid pregnancy outcome, we examined the risk of The approach used for the development of our study cohort has previously been described in detail.…”
Section: Hhs Public Accessmentioning
confidence: 99%
“…[9][10][11][12][13] The negative studies tended to be small, raising the possibility that they had insufficient power to detect an increased risk. 10,11 Given the ongoing controversy regarding the association between SSRI exposure in late pregnancy and the risk of this highly morbid pregnancy outcome, we examined the risk of The approach used for the development of our study cohort has previously been described in detail. 14 We identified all completed pregnancies in women aged 12 to 55 years and linked these pregnancies to live-born infants.…”
mentioning
confidence: 99%
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“…If working means that SSRIs reduce risky behaviors including alcohol and drug intake, the evidence is somewhat to the contrary; SSRIs may increase alcohol and drug use [84,131].…”
Section: Ssris In Pregnancymentioning
confidence: 99%