Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC)

Ramlakhan, Karishma P.; Johnson, Mark R.; Lelonek, Małgorzata; Roos‐Hesselink, Jolien W.; Parsonage, William; Grewal, J.; Jondeau, Guillaume; Maggioni, Aldo P.; Tavazzi, Luigi; Elkayam, Uri; Aquieri, Analía; Saad, Aly; Vega, Hilda Ruda; Hojman, Javier; Caparrós, J.; Blanco, Manuel Vázquez; Arstall, Margaret; Chung, Chang-Min; Mahadavan, Gnanadevan; Aldridge, Emily; Wittwer, M.; Chow, Y Y; Parsonage, William; Lust, Karin; Collins, Nicholas; Warner, Gillian Robinson; Hatton, Rachael; Gordon, Allan; Nyman, Elin; Stein, Joerg I.; Donhauser, E.; Gabriel, Henrique Mesquita; Bahshaliyev, A.; Guliyev, F.; Hasanova, I.; Jahangirov, Tofig; Gasimov, Z.; Salim, Abu; Ahmed, C M; Begum, Firoza; Hoque, MM; Mahmood, Manzoor; Islam, M N; Haque, P.P.; Banerjee, Sajal Krishna; Parveen, Tabassum; Morissens, Marielle; Backer, Julie De; Demulier, Laurent; Hosson, Michèle de; Budts, Werner; Beckx, M.; Kozić, Mate; Lovrić, Martina; Kovačevic-Preradović, Tamara; Chilingirova, N.; Kratunkov, Pencho; Wahab, Norashikin Abd; McLean, Scott; Gordon, Elaine; Walter, Lisa M.; Marelli, Ariane J.; Montesclaros, A.R.; Monsalve, Germán; Rodriguez, Candela; Balthazar, F.; Quintero, Victor Hugo Gonzalez; Palacio, W.; Cadavid, Lina; Ortiz, E. Munoz; Hoyos, F. Fortich; Guerrero, Edwin Arévalo; Ricardo, João; Penagos, Jesús Velásquez; Vavera, Zdeněk; Prague, C; Popelová, Jana; Vejlstrup, Niels; Grønbeck, Lene; Johansen, Marianne; Ersbøll, AS; Elrakshy, Yahia M.; Eltamawy, K.; Aziz, Mohamad Gamal Abd-El; Nagar, Ansari; Ebaid, H.H.; El-Enin, Hesham Abo; Саед, Муджахид Аббас; Farag, Saleem A.; Makled, W.; Sorour, Khaled; Ashour, Zeinab; Elsayed, Galal; Mahdy, Marwa A.; Taha, Nasser; Dardeer, Ahmed M.; Shabaan, Mohammed; Ali, Mohamed Mandour; Moceri, Pamela; Duthoit, Guillaume; Gouton, Marielle; Nizard, J.; Baris, Lucia; Cohen, Scott B.; Ladouceur, Magalie; Khimoud, Djamal; Iung, Bernard; Berger, Felix; Olsson, A G; Gembruch, U.; Merz, Waltraut M.; Reinert, E.; Clade, S.; Kliesch, Y.; Wald, C.; Sinning, Christoph; Kozlik‐Feldmann, Rainer; Blankenberg, Stefan; Zengin-Sahm, Elvin; Mueller, Götz; Hillebrand, Mathias; Hauck, Peer; Kodolitsch, Y. von; Zarniko, N.; Baumgartner, Muenster H.; Schmidt, Renate; Hellige, Antje; Tutarel, Oktay; Kaemmerer, Harald; Kuschel, Bettina; Nagdyman, Nicole; Motz, Reinald; Maisuradze, D.; Frogoudaki, Alexandra; Iliodromitis, Efstathios K.; Anastasiou-Nana, Maria; Marousi, N; Triantafyllis, Demetrios; Bekiaris, G.; Karvounis, Haris; Giannakoulas, George; Ntiloudi, Despοina; Mouratoglou, Sofia; Temesvári, A; Balint, H; Kohalmi, Dora; Merkely, B; Liptai, Csilla; Nemes, A.; Forster, Tamás; Kalapos, Anita; Berek, Kinga; Havasi, Kálmán; Ambrus, Nóra; Shelke, Abhijeet; Kawade, Ramesh; Patil, S.; Martanto, Erwan; Aprami, Toni M.; Purnomowati, Augustine; Cool, Charlotte Johanna; Hasan, Marwa H.; Akbar, Ruqia; Hidayat, Syarief; Dewi, Triwedya Indra; Permadi, W.; Soedarsono, D.A.; Ansari-Ramandi, M.M.; Samiei, Niloufar; Tabib, Avisa; Kashfi, F; Ansari-Ramandi, Samaneh; Rezaei, Safoura Sheikh; Farhan, Hasan Ali; Alhussein, Abdelazeem; Al-Saedi, G.; Mahmood, Ghassan M.; Yaseen, Israa Fadhil; Al-Yousuf, L.; Al-Bayati, Maha M.; Mahmood, S.; Raheem, Sura Adnan; Alhaidari, Taghreed; Dakhil, Zainab Atiyah; Thornton, Patrick; Donnelly, J.; M, Bowen; Blatt, Alex; Elbaz‐Greener, Gabby; Shotan, Avraham; Yalonetsky, Sergey; Goland, Sorel; Biener, Moritz; Assenza, Gabriele Egidy; Bonvicini, Marco; Donti, Andrea; Bulgarelli, Adriana; Prandstraller, Daniela; Romeo, Cristina; Crepaz, R; Sciatti, Edoardo; Metra, Marco; Orabona, Rossana; Ali, Liaquat; Festa, Pierluigi; Fesslová, Vlasta; Bonanomi, C.; Calcagnino, Margherita; Lombardi, Federico; Colli, Agostino; Ossola, Manuela Wally; Gobbi, Carla; Gherbesi, Elisa; Tondi, Lara; Schiavone, Marco; Squillace, M; Carmina, Maria Gabriella; Maina, Aldo; Macchi, Claudio; Gollo, E.; Comoglio, Francesca; Montali, Nicolò; Re, Pottinger; Bordese, Roberto; Todros, Tullia; Donvito, Valentina; Marra, Walter Grosso; Sinagra, Gianfranco; Mottolese, Biancamaria D’Agata; Bobbo, Marco; Gesuete, Valentina; Rakar, Serena; Ramani, Federica; Niwa, Koichiro; Mekebekova, D.; Mussagaliyeva, Aisulu; Lee, T.; Mirrakhimov, Erkin M; Abilova, S.; Bektasheva, E.; Neronova, K.; Lunegova, Olga; Žaliūnas, Remigijus; Jonkaitienė, Regina; Petrauskaitė, Jūratė; Laucevičius, Aleksandras; Jančauskaitė, Dovilė; Lauciuviene, L.; Gumbienė, Lina; Lankutiene, Lina; Glaveckaitė, Sigita; Laukytė, Monika; Solovjova, Svetlana; Rudienė, Virginija; Chee, Kok Han; Yim, CF; Ang, Hak-Lee; Kuppusamy, Ramesh; Watson, T.; Caruana, Maryanne; Estensen, Mette E; Kayani, M.G.A. Mahmood; Munir, Rubab; Tomaszuk‐Kazberuk, Anna; Sobkowicz, Bożena; Przepieść, Jerzy; Leśniak‐Sobelga, Agata; Tomkiewicz‐Pająk, Lidia; Komar, Monika; Olszowska, Maria; Podolec, Piotr; Wiśniowska‐Śmiałek, Sylwia; Faflik, Urszula; Cichocka-Radwan, Anna; Plaskota, Karolina; Trojnarska, Olga; Guerra, N.; Sousa, Lemos; Cruz, Charles S. Dela; Ribeiro, Veronica Martins; Jovanova, Silvana; Petrescu, Vasilica-Flory; Jurcut, Roxandra; Ginghină, Carmen; Coman, Ioan Mircea; Musteață, Mihai; Осипова, О. А.; Голивец, Т. П.; Хамнагадаев, И. А.; Головченко, О. В.; Нагибина, А. И.; Ropatko, I.; Gaisin, I.R.; Шилина, Л. В.; Шарашкина, Н. В.; Shlyakhto, E. V.; Irtyuga, Olga; Moiseeva, O.; Karelkina, E; Zazerskaya, Irina E.; Козленок, А. В.; Сухова, И. В.; Jovović, Ljiljana; Prokšelj, Katja; Koželj, Mirta; Askar, A.O.; Abdilaahi, A.A.; Mohamed, Marwa; Dirir, A.M.; Sliwa, Karen; Manga, Pravin; Pijuan‐Domenech, Antònia; Galián-Gay, Laura; Tornos, Pilar; Subirana, María Teresa; Subirana, Sebastià Riu; Oliver, Josè M.; Dominguez, B. Garcia-Aranda; González, Ignacio Hernández; Jiménez, Juan F. Delgado; Subías, Pilar Escribano; Murga, Nekane; Elbushi, A.; Suliman, Ahmed; Jazzar, K.; Murtada, M.; Ahamed, N.; Dellborg, Mikael; Furenäs, Eva; Jinesjo, M; Skoglund, Kristofer; Eriksson, Peter; Gilljam, Thomas; Thilén, Ulf; Tobler, Daniel; Wustmann, Kerstin; Schwitz, Fabienne; Schwerzmann, Markus; Rutz, Tobias; Bouchardy, Judith; Greutmann, Matthias; Lopes, B.M. Santos; Meier, Lukas; Arrigo, Mattia; Boer, Karin; Konings, T.C.; Wajon, Elly M.C.J.; Wagenaar, Lodewijk J.; Polak, Peter; Pieper, Els; Hagen, Iris van; Duvekot, Hans; Cornette, Jérôme; Groot, Christianne de; Oppen, C. van; Sarac, L.; Esen, Özlem; Enar, Sibel; Mondo, Charles; Ingabire, Prossie Merab; Nalwanga, B.; Semu, T.; Salih, Bashir; Almahmeed, Wael; Wani, Sheeba; Farook, Fathima; Ain, Al; Gerges, Fady; Komaranchath, Austin; Bakshi, Fary; Mulla, Ahmed Al; Yusufali, Afzal Hussein; Hatou, E.I. Al; Bazargani, Nooshin; Hussain, Farrukh; Hudsmith, Lucy; Thompson, Peter J.; Thorne, Sara; Bowater, Sarah; Money-Kyrle, Andrew R.W.; Clifford, Piers; Ramrakha, Punit S.; Firoozan, Soroosh; Chaplin, Josephine; Bowers, Nicolas; Adamson, Dawn; Schroeder, Frank; Wendler, Renate; Hammond, Sarah; Nihoyannopoulos, Petros; Norfolk, Norwich; Hall, Roger; Freeman, Leisa J; Veldtman, G.; Kerr, J. M. Munro; Tellett, L.; Scott, Nandita S.; Bhatt, Ami B.; Yeh, Doreen DeFaria; Youniss,; Wood, Malissa J.; Sarma, Amy; Tsiaras, Sarah; Stefanescu, Ada; Duran, Jessica; Stone, Lawson G.; Majdalany, David; Chapa, Jeffrey; Chintala, Kavitha; Gupta, Prashanta Krishna; Botti, John J.; Ting, Jennifer; Davidson, William R.; Wells, Gretchen; Sparks, D. Larry; Paruchuri, Vikram; Marzo, Kevin; Patel, Deesha A.; Wagner, William R.; Ahanya, Sureshbabu N; Colicchia, Laura C.; Jentink, T.; Han, Kyu-Rock; Loichinger, Matthew; Parker, Margarct M.; Longtin, C.; Yetman, Anji T.; Erickson, Kirk I.; Cramer, Jonathan; Tsai, Sandra; Fletcher, Barbara J.; Warta, Sanne; Cohen, Cyril; Lindblade, Christopher; Puntel, Robert; Nagaran, K.; Croft, Nick; Gurvitz, Michelle; Otto, Catherine M.; Talluto, C.; Murphy, Deirdre J; Perlroth, Mark G.

doi:10.1016/j.ijcchd.2021.100107

Cited by 7 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result, Eisenmenger's syndrome has a very high incidence of mortality, reaching 9.7%. [10] In recent years, the maternal mortality rate among pregnant women with pulmonary hypertension has decreased from 25%-56% to 17%-33%, mostly associated with target therapy for pulmonary hypertension and advances in the management of high-risk pregnancies in intensive care units. (ICU).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Hypertension in Pregnancy: A Cardiological Approach to Maternal Outcomes as well as Neonatal and Therapeutic Management

Yusa,

Maulana

2024

CCJ

View full text Add to dashboard Cite

Highlights: 1. Pulmonary hypertension is threatening to both the mother and the infant in the womb. 2. This report discusses the complexity of physiological changes in pregnant women with pulmonary hypertension. - Abstract Background: Maternal morbidity and mortality with pulmonary hypertension in pregnancy usually occur during labor until early postpartum. Historical reports have shown mortality rates as high as 30–56%. We report a 32-year-old female patient pregnant with her second child, with complaints of bleeding from the birth canal since 1 hour before admission to the hospital and a history of atrial septal defect type secundum. Case presentation: The patient was diagnosed with G2P1A0, 16–17 weeks pregnant, with death conception, thrombocytopenia, and ASD secundum with pulmonary hypertension. The patient was planned for dilation and curettage by the obstetrics and gynecology departments. As a result of consultation with the cardiology department, medication management was given, and the decision to tolerate CRI IV very high-risk surgery was given. Conclusion: Despite progress, pregnancy remains poorly tolerated in cases of pulmonary hypertension. Management should remain focused on contraceptive counseling and offering early termination when pregnancy does occur

show abstract

Section: Discussionmentioning

confidence: 99%

Pulmonary Hypertension in Pregnancy: A Cardiological Approach to Maternal Outcomes as well as Neonatal and Therapeutic Management

Yusa,

Maulana

2024

CCJ

View full text Add to dashboard Cite

show abstract

“… 9–15 The incidence of heart failure or thromboembolic events that we found is comparable with the rates reported in a study on pregnancy outcomes in women with CHD (7.4% vs 6.6% and 2.5% vs 1.2%), but arrhythmia seems to be more common in women with Ebstein’s anomaly (3.7% vs 1.2%). 20 The retrospective study of Connolly et al , which included 111 pregnancies in 44 women with Ebstein’s anomaly, reported no deaths and no serious maternal complications during pregnancy or post partum, including heart failure, life-threatening arrhythmias, endocarditis or thromboembolic events. 10 This contrasts to our data where we observed an MACE rate of 9.9%, despite similar prepregnancy characteristics.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes in women with Ebstein’s anomaly: data from the Registry of Pregnancy And Cardiac disease (ROPAC)

van der Zande,

Tutarel,

Ramlakhan

et al. 2023

Open Heart

Self Cite

View full text Add to dashboard Cite

ObjectiveEbstein’s anomaly is a rare congenital cardiac condition and data regarding pregnancy outcomes in this patient group are scarce. We evaluated the maternal and perinatal risks of pregnancy in 81 women with Ebstein’s anomaly.MethodsThe Registry of Pregnancy and Cardiac disease is a prospective global registry of pregnancies in women with structural cardiac disease. Pregnancy outcomes in women with Ebstein’s anomaly were examined. The primary outcome was the occurrence of a major adverse cardiac event (MACE) defined as maternal mortality, heart failure, arrhythmia, thromboembolic event or endocarditis. Secondary endpoints were obstetric and perinatal outcomes and the influence of pregnancy on tricuspid valve regurgitation as well as right atrial and ventricular dimensions.ResultsIn the 81 women with Ebstein’s anomaly (mean age 29.7±6.1 years, 46.9% nulliparous), MACE occurred in 8 (9.9%) pregnancies, mostly heart failure (n=6). There were no maternal deaths. Prepregnancy signs of heart failure were predictive for MACE. Almost half of the women were delivered by caesarean section (45.7%) and preterm delivery occurred in 24.7%. Neonatal mortality was 2.5% and 4.9% of the infants had congenital heart disease. In the subgroup in which prepregnancy and postpregnancy data were available, there was no difference in tricuspid valve regurgitation grade or right atrial and ventricular dimensions before and after pregnancy.ConclusionsMost women with Ebstein’s anomaly tolerate pregnancy well, but women with prepregnancy signs of heart failure are at higher risk for MACE during pregnancy and should be counselled accordingly.

show abstract

“…Cardiovascular disease is a leading cause of indirect maternal death. While the overall risk of adverse outcomes in pregnancy in women with CHD is relatively small,2 the long-term impact is not well understood, with the European Society of Cardiology (ESC) guidelines describing a gap in evidence, which this study helps to address 3. Son et al 1 applied the mWHO classification system as a means of categorising CHD.…”

Section: Commentarymentioning

confidence: 99%

“…A total of 1%–4% of pregnancies are complicated by maternal heart disease, mostly commonly CHD with increasing numbers of women with CHD embarking on parenthood 2. While published data identifies risk stratification related to pregnancy, including risks associated with specific conditions, long-term outcomes are less clear.…”

Section: Contextmentioning

confidence: 99%

Maternal congenital heart disease can have adverse long-term outcomes

Gillespie

2022

Evid Based Nurs

View full text Add to dashboard Cite

Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC)

Cited by 7 publications

References 23 publications

Pulmonary Hypertension in Pregnancy: A Cardiological Approach to Maternal Outcomes as well as Neonatal and Therapeutic Management

Pulmonary Hypertension in Pregnancy: A Cardiological Approach to Maternal Outcomes as well as Neonatal and Therapeutic Management

Pregnancy outcomes in women with Ebstein’s anomaly: data from the Registry of Pregnancy And Cardiac disease (ROPAC)

Maternal congenital heart disease can have adverse long-term outcomes

Contact Info

Product

Resources

About